Search Results - "Hunt, Martina"
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Dual-locus, dual-HDR editing permits efficient generation of antigen-specific regulatory T cells with robust suppressive activity
Published in Molecular therapy (04-10-2023)“…Adoptive regulatory T (Treg) cell therapy is predicted to modulate immune tolerance in autoimmune diseases, including type 1 diabetes (T1D). However, the…”
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Potential Regulation of UGT2B10 and UGT2B7 by miR-485-5p in Human Liver
Published in Molecular pharmacology (01-12-2019)“…The UDP-glucuronosyltransferase (UGT) family of enzymes is important in the metabolic elimination of a variety of endogenous compounds such as bile acids,…”
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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes
Published in JCI insight (08-02-2024)“…Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving β cell function…”
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