Search Results - "Hunt, Karen"

Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people by Finer, Sarah, Martin, Hilary C, Khan, Ahsan, Hunt, Karen A, MacLaughlin, Beverley, Ahmed, Zaheer, Ashcroft, Richard, Durham, Ceri, MacArthur, Daniel G, McCarthy, Mark I, Robson, John, Trivedi, Bhavi, Griffiths, Chris, Wright, John, Trembath, Richard C, van Heel, David A

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Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease by Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L, Trynka, Gosia, Hunt, Karen A, Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A, Wijmenga, Cisca, de Bakker, Paul I W

“…Cisca Wijmenga and colleagues report fine mapping of the association signal in the MHC region in individuals with celiac disease. They identify five additional…”
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Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals by Huang, Qin Qin, Sallah, Neneh, Dunca, Diana, Trivedi, Bhavi, Hunt, Karen A., Hodgson, Sam, Lambert, Samuel A., Arciero, Elena, Wright, John, Griffiths, Chris, Trembath, Richard C., Hemingway, Harry, Inouye, Michael, Finer, Sarah, van Heel, David A., Lumbers, R. Thomas, Martin, Hilary C., Kuchenbaecker, Karoline

“…Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data…”
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Censorship and Self-Censorship: Revisiting the Belt Case in the Making of Dora Montefiore (1851–1933) by Hunt, Karen

“…The Belt Case was a series of events that occurred in 1899 and 1900. At their heart sat gossip about Dora Montefiore (1851–1933) and an ‘inappropriate…”
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Comparative Analysis of NCLEX-RN Questions: A Duel Between ChatGPT and Human Expertise by Cox, Rachel L., Hunt, Karen L., Hill, Rebecca R.

“…Background: Artificial intelligence (AI) has the potential to revolutionize nursing education. This study compared NCLEX-RN questions generated by AI and those…”
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Health and population effects of rare gene knockouts in adult humans with related parents by Narasimhan, Vagheesh M., Hunt, Karen A., Mason, Dan, Baker, Christopher L., Karczewski, Konrad J., Barnes, Michael R., Barnett, Anthony H., Bates, Chris, Bellary, Srikanth, Bockett, Nicholas A., Giorda, Kristina, Griffiths, Christopher J., Hemingway, Harry, Jia, Zhilong, Kelly, M. Ann, Khawaja, Hajrah A., Lek, Monkol, McCarthy, Shane, McEachan, Rosie, O'Donnell-Luria, Anne, Paigen, Kenneth, Parisinos, Constantinos A., Sheridan, Eamonn, Southgate, Laura, Tee, Louise, Thomas, Mark, Xue, Yali, Schnall-Levin, Michael, Petkov, Petko M., Tyler-Smith, Chris, Maher, Eamonn R., Trembath, Richard C., MacArthur, Daniel G., Wright, John, Durbin, Richard, van Heel, David A.

“…Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British adults of Pakistani heritage…”
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Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease by Smyth, Deborah J, Plagnol, Vincent, Walker, Neil M, Cooper, Jason D, Downes, Kate, Yang, Jennie H.M, Howson, Joanna M.M, Stevens, Helen, McManus, Ross, Wijmenga, Cisca, Heap, Graham A, Dubois, Patrick C, Clayton, David G, Hunt, Karen A, van Heel, David A, Todd, John A

“…Type 1 diabetes and celiac disease, both of which are associated with HLA class II genes, cosegregate in populations, suggesting a common genetic origin. In…”
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Fine-scale population structure and demographic history of British Pakistanis by Arciero, Elena, Dogra, Sufyan A., Malawsky, Daniel S., Mezzavilla, Massimo, Tsismentzoglou, Theofanis, Huang, Qin Qin, Hunt, Karen A., Mason, Dan, Sharif, Saghira Malik, van Heel, David A., Sheridan, Eamonn, Wright, John, Small, Neil, Carmi, Shai, Iles, Mark M., Martin, Hilary C.

“…Previous genetic and public health research in the Pakistani population has focused on the role of consanguinity in increasing recessive disease risk, but…”
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Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria by McGregor, Tracy L, Hunt, Karen A, Yee, Elaine, Mason, Dan, Nioi, Paul, Ticau, Simina, Pelosi, Marissa, Loken, Perry R, Finer, Sarah, Lawlor, Deborah A, Fauman, Eric B, Huang, Qin Qin, Griffiths, Christopher J, MacArthur, Daniel G, Trembath, Richard C, Oglesbee, Devin, Lieske, John C, Erbe, David V, Wright, John, van Heel, David A

“…By sequencing autozygous human populations, we identified a healthy adult woman with lifelong complete knockout of (expected ~1 in 30 million outbred people)…”
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Negligible impact of rare autoimmune-locus coding-region variants on missing heritability by Hunt, Karen A., Mistry, Vanisha, Bockett, Nicholas A., Ahmad, Tariq, Ban, Maria, Barker, Jonathan N., Barrett, Jeffrey C., Blackburn, Hannah, Brand, Oliver, Burren, Oliver, Capon, Francesca, Compston, Alastair, Gough, Stephen C. L., Jostins, Luke, Kong, Yong, Lee, James C., Lek, Monkol, MacArthur, Daniel G., Mansfield, John C., Mathew, Christopher G., Mein, Charles A., Mirza, Muddassar, Nutland, Sarah, Onengut-Gumuscu, Suna, Papouli, Efterpi, Parkes, Miles, Rich, Stephen S., Sawcer, Steven, Satsangi, Jack, Simmonds, Matthew J., Trembath, Richard C., Walker, Neil M., Wozniak, Eva, Todd, John A., Simpson, Michael A., Plagnol, Vincent, van Heel, David A.

“…A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region…”
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Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing by Heap, Graham A., Yang, Jennie H.M., Downes, Kate, Healy, Barry C., Hunt, Karen A., Bockett, Nicholas, Franke, Lude, Dubois, Patrick C., Mein, Charles A., Dobson, Richard J., Albert, Thomas J., Rodesch, Matthew J., Clayton, David G., Todd, John A., van Heel, David A., Plagnol, Vincent

“…Many disease-associated variants identified by genome-wide association (GWA) studies are expected to regulate gene expression. Allele-specific expression (ASE)…”
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Exome sequencing of 75 individuals from multiply affected coeliac families and large scale resequencing follow up by Mistry, Vanisha, Bockett, Nicholas A, Levine, Adam P, Mirza, Muddassar M, Hunt, Karen A, Ciclitira, Paul J, Hummerich, Holger, Neuhausen, Susan L, Simpson, Michael A, Plagnol, Vincent, van Heel, David A

“…Coeliac disease (CeD) is a highly heritable common autoimmune disease involving chronic small intestinal inflammation in response to dietary wheat. The human…”
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Complex nature of SNP genotype effects on gene expression in primary human leucocytes by Heap, Graham A, Trynka, Gosia, Jansen, Ritsert C, Bruinenberg, Marcel, Swertz, Morris A, Dinesen, Lotte C, Hunt, Karen A, Wijmenga, Cisca, Vanheel, David A, Franke, Lude

“…Genome wide association studies have been hugely successful in identifying disease risk variants, yet most variants do not lead to coding changes and how…”
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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease by van Heel, David A, Ghosh, Subrata, Butler, Matt, Hunt, Karen A, Lundberg, Anna MC, Ahmad, Tariq, McGovern, Dermot PB, Onnie, Clive, Negoro, Kenichi, Goldthorpe, Sue, Foxwell, Brian MJ, Mathew, Christopher G, Forbes, Alastair, Jewell, Derek P, Playford, Raymond J

“…Both NOD2 (CARD15) alleles are mutated in roughly 15% of patients with Crohn's disease, but functional effects are unclear. We analysed the cytokine response…”
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Challenge Studies to Determine the Ability of Foods to Support the Growth of Listeria monocytogenes by Hunt, Karen, Blanc, Marjorie, Álvarez-Ordóñez, Avelino, Jordan, Kieran

“…is a foodborne pathogen that causes listeriosis, a relatively rare, but potentially fatal, disease, with a mortality rate of 20⁻30%. In general, European…”
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case of bovine raw milk contamination with Listeria monocytogenes by Hunt, Karen, Drummond, Niall, Murphy, Mary, Butler, Francis, Buckley, Jim, Jordan, Kieran

“…During routine sampling of bulk raw milk on a dairy farm, the pathogenic bacteria Listeria monocytogenes was found to be a contaminant, at numbers < 100…”
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Clinical and radiologic assessments to predict breast cancer pathologic complete response to neoadjuvant chemotherapy by SCHOTT, Anne F, ROUBIDOUX, Marilyn A, PARAMAGUL, Chintana, BAKER, Laurence H, HELVIE, Mark A, HAYES, Daniel F, KLEER, Celina G, NEWMAN, Lisa A, PIERCE, Lori J, GRIFFITH, Kent A, MURRAY, Susan, HUNT, Karen A

“…To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine…”
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Synergistic enhancement of Toll‐like receptor responses by NOD1 activation by van Heel, David A., Ghosh, Subrata, Butler, Matt, Hunt, Karen, Foxwell, Brian Michael J., Mengin‐Lecreulx, Dominique, Playford, Raymond J.

“…NOD1 is an intracellular pattern‐recognition receptor specific for Gram‐negative peptidoglycan that is important in host response to infections (e.g…”
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Recent advances in coeliac disease genetics by Hunt, Karen A, van Heel, David A

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 by van Heel, David A, Franke, Lude, Hunt, Karen A, Gwilliam, Rhian, Zhernakova, Alexandra, Inouye, Mike, Wapenaar, Martin C, Barnardo, Martin C N M, Bethel, Graeme, Holmes, Geoffrey K T, Feighery, Con, Jewell, Derek, Kelleher, Dermot, Kumar, Parveen, Travis, Simon, Walters, Julian RF, Sanders, David S, Howdle, Peter, Swift, Jill, Playford, Raymond J, McLaren, William M, Mearin, M Luisa, Mulder, Chris J, McManus, Ross, McGinnis, Ralph, Cardon, Lon R, Deloukas, Panos, Wijmenga, Cisca

“…We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding…”
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