Search Results - "Hunt, Gregory N."

Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Chen, Ning, Wu, Wen-Jian, Yuan, Fangping, O’Brien, Erin, Wang, Tao, Luo, Li, Hunt, Gregory N., Zhu, Xiaoping, Bolli, Roberto

“…A model of intracoronary stem cell delivery that enables transgenesis/gene targeting would be a powerful tool but is still lacking. To address this gap, we…”
Get full text

The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): A New Paradigm for Rigorous, Accurate, and Reproducible Evaluation of Putative Infarct-Sparing Interventions in Mice, Rabbits, and Pigs by Jones, Steven P, Tang, Xian-Liang, Guo, Yiru, Steenbergen, Charles, Lefer, David J, Kukreja, Rakesh C, Kong, Maiying, Li, Qianhong, Bhushan, Shashi, Zhu, Xiaoping, Du, Junjie, Nong, Yibing, Stowers, Heather L, Kondo, Kazuhisa, Hunt, Gregory N, Goodchild, Traci T, Orr, Adam, Chang, Carlos C, Ockaili, Ramzi, Salloum, Fadi N, Bolli, Roberto

“…RATIONALE:Despite 4 decades of intense effort and substantial financial investment, the cardioprotection field has failed to deliver a single drug that…”
Get full text

Effects of Intracoronary Infusion of Escalating Doses of Cardiac Stem Cells in Rats With Acute Myocardial Infarction by Tang, Xian-Liang, Rokosh, Gregg, Sanganalmath, Santosh K, Tokita, Yukichi, Keith, Matthew C L, Shirk, Gregg, Stowers, Heather, Hunt, Gregory N, Wu, Wenjian, Dawn, Buddhadeb, Bolli, Roberto

“…Although c-kit(pos) cardiac stem cells (CSCs) preserve left ventricular (LV) function and structure after myocardial infarction, CSC doses have been chosen…”
Get full text

DOSE-DEPENDENT EFFECTS OF INTRACORONARY CARDIAC STEM CELLS IN RATS WITH ACUTE MYOCARDIAL INFARCTION by Tang, Xian-Liang, Rokosh, Gregg, Sanganalmath, Santosh K, Shirk, Gregg, Stowers, Heather, Hunt, Gregory N, Dawn, Buddhadeb, Bolli, Roberto

“…Echocardiography showed ejection fraction (EF), infarct wall thickening fraction (IW ThF), and LV end-systolic volume (LVESV) were improved significantly in…”
Get full text

Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Wu, Wen-Jian, Chen, Ning, Zhu, Xiaoping, Tan, Wei, Yuan, Fangping, Dawn, Buddhadeb, Luo, Li, Hunt, Gregory N., Bolli, Roberto

“…Extensive evidence indicates that heme oxygenase-1 (HO-1) exerts potent cytoprotective effects in response to stress. Previous studies have shown that gene…”
Get full text

Abstract 25: A Streamlined Technique to Stabilize C-kit Expression in Cardiac Mesenchymal Cells by Dassanayaka, Sujith, Long, Bethany W, Zafir, Ayesha, Ghafghazi, Shahab, Hunt, Gregory N, Noble, Camille T, DeMartino, Angelica M, Brittian, Kenneth R, Jones, Steven P, Wysoczynski, Marcin

“…Abstract only Adoptive transfer of various reparative cells attenuates cardiac dysfunction in preclinical models of heart failure. Although c-kit sorted cells…”
Get full text

Abstract 15555: Administration of c-Kit+ Cardiac Stem Cells (CSCs) Results in Increased Proliferation and Cardiac Content of CSCs 1 Year Later by Li, Qianhong, Chen, Ning, Luo, Li, Ou, Qinghui, Xie, Wei, Hunt, Gregory N, Tang, Xian-Liang, Rokosh, Gregg D, Bolli, Roberto

“…Abstract only Background: We have previously shown in rats that the beneficial effects of c-kit + CSCs on LV function and remodeling post-myocardial infarction…”
Get full text

Abstract 9546: Effects of Endogenous Hydrogen Sulfide on Differentiation of Cardiac Stem Cells by Li, Qianhong, Luo, Li, Chen, Ning, Ou, Qinghui, O'Brien, Erin M, Yuan, Fangping, Hunt, Gregory N, O'Toole, Timothy, Guo, Yiru, Bolli, Roberto

“…Abstract only Although hydrogen sulfide (H 2 S) has recently emerged as a novel gaseous transmitter with important cardioprotective properties, nothing is…”
Get full text