Search Results - "Hunt, Debbie M."

Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches by Green, Jeffrey, Stapleton, Melanie R, Smith, Laura J, Artymiuk, Peter J, Kahramanoglou, Christina, Hunt, Debbie M, Buxton, Roger S

“…Highlights • E. coli cyclic-AMP receptor protein (CRP) is a paradigm of gene regulation. • Comparison of CRPs reveals differences in their affinity of cAMP. •…”
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Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis by Agapova, Aleksandra, Serafini, Agnese, Petridis, Michael, Hunt, Debbie M, Garza-Garcia, Acely, Sohaskey, Charles D, de Carvalho, Luiz Pedro Sório

“…Bacterial metabolism is fundamental to survival and pathogenesis. We explore how utilises amino acids as nitrogen sources, using a combination of bacterial…”
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis by Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P., Green, Jeffrey

“…Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims ~1.8 million human lives per annum. Host nitric oxide (NO) is important in controlling…”
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Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis by Larrouy-Maumus, Gérald, Biswas, Tapan, Hunt, Debbie M., Kelly, Geoff, Tsodikov, Oleg V., de Carvalho, Luiz Pedro Sório

“…Functional assignment of enzymes encoded by the Mycobacterium tuberculosis genome is largely incomplete despite recent advances in genomics and bioinformatics…”
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Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster by Smith, Laura J, Stapleton, Melanie R, Fullstone, Gavin J M, Crack, Jason C, Thomson, Andrew J, Le Brun, Nick E, Hunt, Debbie M, Harvey, Evelyn, Adinolfi, Salvatore, Buxton, Roger S, Green, Jeffrey

“…Mycobacterium tuberculosis is a major pathogen that has the ability to establish, and emerge from, a persistent state. Wbl family proteins are associated with…”
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Mycobacterium tuberculosis cAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties by Stapleton, Melanie, Haq, Ihtshamul, Hunt, Debbie M., Arnvig, Kristine B., Artymiuk, Peter J., Buxton, Roger S., Green, Jeffrey

“…The pathogen Mycobacterium tuberculosis produces a burst of cAMP upon infection of macrophages. Bacterial cyclic AMP receptor proteins (CRP) are transcription…”
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Long-Range Transcriptional Control of an Operon Necessary for Virulence-Critical ESX-1 Secretion in Mycobacterium tuberculosis by Hunt, Debbie M, Sweeney, Nathan P, Mori, Luisa, Whalan, Rachael H, Comas, Iñaki, Norman, Laura, Cortes, Teresa, Arnvig, Kristine B, Davis, Elaine O, Stapleton, Melanie R, Green, Jeffrey, Buxton, Roger S

“…The ESX-1 secretion system of Mycobacterium tuberculosis has to be precisely regulated since the secreted proteins, although required for a successful virulent…”
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Single Nucleotide Polymorphisms That Cause Structural Changes in the Cyclic AMP Receptor Protein Transcriptional Regulator of the Tuberculosis Vaccine Strain Mycobacterium bovis BCG Alter Global Gene Expression without Attenuating Growth by Hunt, Debbie M, Saldanha, José W, Brennan, John F, Benjamin, Pearline, Strom, Molly, Cole, Jeffrey A, Spreadbury, Claire L, Buxton, Roger S

“…Single nucleotide polymorphisms (SNPs) are present in the global transcriptional regulator cyclic AMP (cAMP) receptor protein (CRP) of the attenuated vaccine…”
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An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism by Wang, Hua, Fedorov, Alexander A., Fedorov, Elena V., Hunt, Debbie M., Rodgers, Angela, Douglas, Holly L., Garza-Garcia, Acely, Bonanno, Jeffrey B., Almo, Steven C., de Carvalho, Luiz Pedro Sório

“…Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting…”
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ABC Transporter Containing a Forkhead-Associated Domain Interacts with a Serine-Threonine Protein Kinase and Is Required for Growth of Mycobacterium tuberculosis in Mice by Curry, Juliet M, Whalan, Rachael, Hunt, Debbie M, Gohil, Kalpesh, Strom, Molly, Rickman, Lisa, Colston, M. Joseph, Smerdon, Stephen J, Buxton, Roger S

“…Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA…”
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Design, Synthesis, and Characterization of N‑Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity by dos Santos Fernandes, Guilherme Felipe, de Souza, Paula Carolina, Moreno-Viguri, Elsa, Santivañez-Veliz, Mery, Paucar, Rocio, Pérez-Silanes, Silvia, Chegaev, Konstantin, Guglielmo, Stefano, Lazzarato, Loretta, Fruttero, Roberta, Man Chin, Chung, da Silva, Patricia Bento, Chorilli, Marlus, Solcia, Mariana Cristina, Ribeiro, Camila Maríngolo, Silva, Caio Sander Paiva, Marino, Leonardo Biancolino, Bosquesi, Priscila Longhin, Hunt, Debbie M, de Carvalho, Luiz Pedro S, de Souza Costa, Carlos Alberto, Cho, Sang Hyun, Wang, Yuehong, Franzblau, Scott Gary, Pavan, Fernando Rogério, dos Santos, Jean Leandro

“…Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new…”
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Genomic mapping of cAMP receptor protein (CRP Mt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor by Kahramanoglou, Christina, Cortes, Teresa, Matange, Nishad, Hunt, Debbie M, Visweswariah, Sandhya S, Young, Douglas B, Buxton, Roger S

“…Chromatin immunoprecipitation identified 191 binding sites of Mycobacterium tuberculosis cAMP receptor protein (CRP(Mt)) at endogenous expression levels using…”
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Long range transcriptional control of virulence critical genes in Mycobacterium tuberculosis by nucleoid-associated proteins? by Buxton, Roger S., Green, Jeffrey, Hunt, Debbie M., Kahramanoglou, Christina, Stapleton, Melanie R., Sweeney, Nathan P.

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Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis by Khan, Mehak Zahoor, Hunt, Debbie M, Singha, Biplab, Kapoor, Yogita, Singh, Nitesh Kumar, Prasad, D V Sai, Dharmarajan, Sriram, Sowpati, Divya Tej, de Carvalho, Luiz Pedro S, Nandicoori, Vinay Kumar

“…'s ( ) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing…”
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Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence by Smith, Laura J, Bochkareva, Aleksandra, Rolfe, Matthew D, Hunt, Debbie M, Kahramanoglou, Christina, Braun, Yvonne, Rodgers, Angela, Blockley, Alix, Coade, Stephen, Lougheed, Kathryn E A, Hafneh, Nor Azian, Glenn, Sarah M, Crack, Jason C, Le Brun, Nick E, Saldanha, José W, Makarov, Vadim, Nobeli, Irene, Arnvig, Kristine, Mukamolova, Galina V, Buxton, Roger S, Green, Jeffrey

“…Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state…”
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A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor by Rickman, Lisa, Scott, Colin, Hunt, Debbie M., Hutchinson, Thomas, Menéndez, M. Carmen, Whalan, Rachael, Hinds, Jason, Colston, M. Joseph, Green, Jeffrey, Buxton, Roger S.

“…Summary Deletion of gene Rv3676 in Mycobacterium tuberculosis coding for a transcription factor belonging to the cAMP receptor protein (CRP) family caused…”
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Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2 by Stapleton, Melanie R, Smith, Laura J, Hunt, Debbie M, Buxton, Roger S, Green, Jeffrey

“…Summary A central feature of TB pathogenesis is the formation of Mycobacterium tuberculosis latent infections that can persist for decades. Nitric oxide…”
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Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response by Matange, Nishad, Hunt, Debbie M, Buxton, Roger S, Visweswariah, Sandhya S

“…Summary The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been…”
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An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis by Nott, Timothy J, Kelly, Geoff, Stach, Lasse, Li, Jiejin, Westcott, Sarah, Patel, Dony, Hunt, Debbie M, Howell, Steven, Buxton, Roger S, O'Hare, Helen M, Smerdon, Stephen J

“…Forkhead-associated (FHA) domains have gained considerable prominence as ubiquitous phosphothreonine-dependent binding modules; however, their precise roles in…”
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Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis by Larrouy-Maumus, Gérald, Marino, Leonardo B, Madduri, Ashoka V. R, Ragan, T. J, Hunt, Debbie M, Bassano, Lucrezia, Gutierrez, Maximiliano G, Moody, D. Branch, Pavan, Fernando R, de Carvalho, Luiz Pedro S

“…The mechanisms that lead to phenotypic antibacterial tolerance in bacteria remain poorly understood. We investigate whether changes in NaCl concentration…”
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