Search Results - "Hunt, David L."

Synaptic plasticity of NMDA receptors: mechanisms and functional implications by Hunt, David L, Castillo, Pablo E

“…Highlights ► NMDARs exhibit diverse functional role based on their unique biophysical properties. ► We review current work describing activity-dependent…”
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Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons by Linaro, Daniele, Levy, Matthew J, Hunt, David L

“…The transformation of synaptic input into action potential output is a fundamental single-cell computation resulting from the complex interaction of distinct…”
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Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1 by Castillo, Pablo E, Tomita, Susumu, Straub, Christoph, Hunt, David L, Yamasaki, Miwako, Kim, Kwang S, Watanabe, Masahiko

“…Of the three major types of ionotropic glutamate receptors, synaptic kainite receptors have slow channel kinetics. This study characterizes Neto1, a novel…”
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Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain by Sugino, Ken, Clark, Erin, Schulmann, Anton, Shima, Yasuyuki, Wang, Lihua, Hunt, David L, Hooks, Bryan M, Tränkner, Dimitri, Chandrashekar, Jayaram, Picard, Serge, Lemire, Andrew L, Spruston, Nelson, Hantman, Adam W, Nelson, Sacha B

“…Understanding the principles governing neuronal diversity is a fundamental goal for neuroscience. Here, we provide an anatomical and transcriptomic database of…”
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NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses by Rangel-Sandoval, Cinthia, Soula, Marisol, Li, Wei-Ping, Castillo, Pablo E., Hunt, David L.

“…Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles…”
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Revealing the Synaptic Hodology of Mammalian Neural Circuits With Multiscale Neurocartography by Bloss, Erik B, Hunt, David L

“…The functional features of neural circuits are determined by a combination of properties that range in scale from projections systems across the whole brain to…”
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ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology by Jin, Dezhe Z., Zhao, Ting, Hunt, David L., Tillage, Rachel P., Hsu, Ching-Lung, Spruston, Nelson

“…Neurons perform computations by integrating inputs from thousands of synapses – mostly in the dendritic tree – to drive action potential firing in the axon…”
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A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus by Hunt, David L., Linaro, Daniele, Si, Bailu, Romani, Sandro, Spruston, Nelson

“…To support cognitive function, the CA3 region of the hippocampus performs computations involving attractor dynamics. Understanding how cellular and ensemble…”
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Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity by Hunt, David L, Puente, Nagore, Grandes, Pedro, Castillo, Pablo E

“…In this paper, Hunt and colleagues provide the first demonstration of bidirectional plasticity of NMDA receptor–mediated synaptic transmission at the…”
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Multimodal in vivo brain electrophysiology with integrated glass microelectrodes by Hunt, David L., Lai, Chongxi, Smith, Richard D., Lee, Albert K., Harris, Timothy D., Barbic, Mladen

“…Electrophysiology is the most used approach for the collection of functional data in basic and translational neuroscience, but it is typically limited to…”
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Retrograde Suppression of Post-Tetanic Potentiation at the Mossy Fiber-CA3 Pyramidal Cell Synapse by Makani, Sachin, Lutzu, Stefano, Lituma, Pablo J, Hunt, David L, Castillo, Pablo E

“…In the hippocampus, the excitatory synapse between dentate granule cell (GC) axons, or mossy fibers (MFs), and CA3 pyramidal cells (MF-CA3) expresses robust…”
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Automated Lead Optimization of MMP-12 Inhibitors Using a Genetic Algorithm by Pickett, Stephen D, Green, Darren V. S, Hunt, David L, Pardoe, David A, Hughes, Ian

“…Traditional lead optimization projects involve long synthesis and testing cycles, favoring extensive structure−activity relationship (SAR) analysis and…”
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The future is bright for the next generation of plant scientists by Hunt, David J. L., Ng, Carl K. Y.

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Brief Report: Genetic Variation of the α1‐Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis by McCarthy, Cormac, Orr, Carl, Fee, Laura T., Carroll, Tomás P., Dunlea, Danielle M., Hunt, David J. L., Dunne, Eimear, O'Connell, Paul, McCarthy, Geraldine, Kenny, Dermot, Fearon, Ursula, Veale, Douglas J., Reeves, Emer P., McElvaney, Noel G.

“…Objective To examine the prevalence of α1‐antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher…”
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Brief Report: Genetic Variation of the α 1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis by McCarthy, Cormac, Orr, Carl, Fee, Laura T, Carroll, Tomás P, Dunlea, Danielle M, Hunt, David J L, Dunne, Eimear, O'Connell, Paul, McCarthy, Geraldine, Kenny, Dermot, Fearon, Ursula, Veale, Douglas J, Reeves, Emer P, McElvaney, Noel G

“…To examine the prevalence of α -antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of…”
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Unique functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1 by Straub, Christoph, Hunt, David L., Yamasaki, Miwako, Kim, Kwang S., Watanabe, Masahiko, Castillo, Pablo E., Tomita, Susumu

“…Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors,…”
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Brief Report: Genetic Variation of the [alpha]1-Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis by McCarthy, Cormac, Orr, Carl, Fee, Laura T, Carroll, Tomás P, Dunlea, Danielle M, Hunt, David J L, Dunne, Eimear, O'Connell, Paul, McCarthy, Geraldine, Kenny, Dermot, Fearon, Ursula, Veale, Douglas J, Reeves, Emer P, McElvaney, Noel G

“…Objective To examine the prevalence of [alpha]1-antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with…”
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Exploring the Developmental Plasticity of Plant Cells: Somatic Embryogenesis in Root Explants by Hunt, David JL

“…The developmental plasticity exhibited by plant cells is well known. However, conventional ideology dictates that only specific subsets of cells within a plant…”
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Application of advanced excitation and analysis techniques to the Galileo Spacecraft modal survey program by Hunt, David L.

“…A modal test of the Galileo Spacecraft will be used to tune a finite element model that will serve in a subsequent loads analysis. A part of the test is being…”
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Multishaker Broadband Excitation for Experimental Modal Analysis by Hunt, David L., Peterson, Edward L.

“…A new method of excitation for modal testing is described which combines the benefits of the two most often used techniques: multipoint sine dwell and…”
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