Search Results - "Hunt, Alan J."

Rapid Microtubule Self-Assembly Kinetics by Gardner, Melissa K., Charlebois, Blake D., Jánosi, Imre M., Howard, Jonathon, Hunt, Alan J., Odde, David J.

“…Microtubule assembly is vital for many fundamental cellular processes. Current models for microtubule assembly kinetics assume that the subunit dissociation…”
Get full text

Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning by Cheng, Jun, Tiyaboonchai, Amita, Yamashita, Yukiko M, Hunt, Alan J

“…Many stem cells divide asymmetrically to balance self-renewal and differentiation. In Drosophila testes, two stem cell populations, germline stem cells (GSCs)…”
Get full text

The Distribution of Polar Ejection Forces Determines the Amplitude of Chromosome Directional Instability by Ke, Kevin, Cheng, Jun, Hunt, Alan J.

“…Polar ejection forces have often been hypothesized to guide directional instability of mitotic chromosomes, but a direct link has never been established. This…”
Get full text

Submicrometer Pore-Based Characterization and Quantification of Antibody-Virus Interactions by Uram, Jeffrey D., Ke, Kevin, Hunt, Alan J., Mayer, Michael

“…A resistive‐pulse sensor (see scheme) employs a submicrometer pore for the detection, characterization, and quantification of the binding of polyclonal…”
Get full text

Optics at Critical Intensity: Applications to Nanomorphing by Joglekar, Ajit P., Liu, Hsiao-hua, Meyhöfer, Edgar, Mourou, Gerard, Hunt, Alan J., Ippen, Erich P.

“…Laser-induced optical breakdown by femtosecond pulses is extraordinarily precise when the energy is near threshold. Despite numerous applications, the basis…”
Get full text

Rapidly Prototyped Three-Dimensional Nanofluidic Channel Networks in Glass Substrates by Ke, Kevin, Hasselbrink, Ernest F, Hunt, Alan J

“…Microfluidic and nanofluidic technologies have long sought a fast, reliable method to overcome the creative limitations of planar fabrication methods, the…”
Get full text

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division by Chen, Cuie, Cummings, Ryan, Mordovanakis, Aghapi, Hunt, Alan J, Mayer, Michael, Sept, David, Yamashita, Yukiko M

“…Asymmetric stem cell division is a critical mechanism for balancing self-renewal and differentiation. Adult stem cells often orient their mitotic spindle to…”
Get full text

Label-Free Affinity Assays by Rapid Detection of Immune Complexes in Submicrometer Pores by Uram, Jeffrey D., Ke, Kevin, Hunt, Alan J., Mayer, Michael

“…Resistance movement: A submicrometer conical pore was used for the single‐aggregate detection and characterization of immune complexes consisting of proteins…”
Get full text

Microtubule assembly dynamics: new insights at the nanoscale by Gardner, Melissa K, Hunt, Alan J, Goodson, Holly V, Odde, David J

“…Although the dynamic self-assembly behavior of microtubule ends has been well characterized at the spatial resolution of light microscopy (∼200 nm), the…”
Get full text

Rapid Microtubule Self-Assembly Kinetics by Gardner, Melissa K., Charlebois, Blake D., Jánosi, Imre M., Howard, Jonathon, Hunt, Alan J., Odde, David J.

Get full text

A Simple, Mechanistic Model for Directional Instability during Mitotic Chromosome Movements by Joglekar, Ajit P., Hunt, Alan J.

“…During mitosis, chromosomes become attached to microtubules that emanate from the two spindle poles. Thereafter, a chromosome moves along these microtubule…”
Get full text

Microtubule Movements on the Arms of Mitotic Chromosomes: Polar Ejection Forces Quantified in vitro by Brouhard, Gary J., Hunt, Alan J., McIntosh, J. Richard

“…During mitosis, "polar ejection forces" (PEFs) are hypothesized to direct prometaphase chromosome movements by pushing chromosome arms toward the spindle…”
Get full text

Spindle Pole Mechanics Studied in Mitotic Asters: Dynamic Distribution of Spindle Forces through Compliant Linkages by Charlebois, Blake D., Kollu, Swapna, Schek, Henry T., Compton, Duane A., Hunt, Alan J.

“…During cell division, chromosomes must faithfully segregate to maintain genome integrity, and this dynamic mechanical process is driven by the macromolecular…”
Get full text

Minimal Plus-end Tracking Unit of the Cytoplasmic Linker Protein CLIP-170 by Gupta, Kamlesh K., Paulson, Benjamin A., Folker, Eric S., Charlebois, Blake, Hunt, Alan J., Goodson, Holly V.

“…Cytoplasmic linker protein 170 (CLIP-170) is the prototype microtubule (MT) plus-end tracking protein (+TIP) and is involved in regulating MT dynamics. A…”
Get full text

Centrosome misorientation reduces stem cell division during ageing by Yamashita, Yukiko M, Fuller, Margaret T, Türkel, Nezaket, Hemati, Nahid, Cheng, Jun, Hunt, Alan J

“…Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. A decline…”
Get full text

Liquid glass electrodes for nanofluidics by Lee, Sanghyun, An, Ran, Hunt, Alan J.

“…Nanofluidic devices make use of molecular-level forces and phenomena to increase their density, speed and accuracy 1 . However, fabrication is challenging,…”
Get full text

Microtubule Assembly Dynamics at the Nanoscale by Schek, Henry T., Gardner, Melissa K., Cheng, Jun, Odde, David J., Hunt, Alan J.

“…The labile nature of microtubules is critical for establishing cellular morphology and motility, yet the molecular basis of assembly remains unclear. Here we…”
Get full text

Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis by Yamashita, Yukiko M, Yuan, Hebao, Cheng, Jun, Hunt, Alan J

“…Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions…”
Get full text

High-aspect ratio nanochannel formation by single femtosecond laser pulses by Herbstman, Jeffrey F, Hunt, Alan J

“…Single femtosecond pulsed laser damage can be confined radially to regions smaller than the focus spot size due to the highly nonlinear mechanisms for energy…”
Get full text

Nanoscale Protein Patterning by Imprint Lithography by Hoff, J. Damon, Cheng, Li-Jing, Meyhöfer, Edgar, Guo, L. Jay, Hunt, Alan J

“…Selective localization of active proteins to patterns or specific sites is important for development of biosensors, bioMEMS, tissue engineering, and basic…”
Get full text