Search Results - "Hunsicker, Lawrence G."

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia by Hering, Bernhard J, Clarke, William R, Bridges, Nancy D, Eggerman, Thomas L, Alejandro, Rodolfo, Bellin, Melena D, Chaloner, Kathryn, Czarniecki, Christine W, Goldstein, Julia S, Hunsicker, Lawrence G, Kaufman, Dixon B, Korsgren, Olle, Larsen, Christian P, Luo, Xunrong, Markmann, James F, Naji, Ali, Oberholzer, Jose, Posselt, Andrew M, Rickels, Michael R, Ricordi, Camillo, Robien, Mark A, Senior, Peter A, Shapiro, A M James, Stock, Peter G, Turgeon, Nicole A

“…Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes…”
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Phase 3 trial of human islet‐after‐kidney transplantation in type 1 diabetes by Markmann, James F., Rickels, Michael R., Eggerman, Thomas L., Bridges, Nancy D., Lafontant, David E., Qidwai, Julie, Foster, Eric, Clarke, William R., Kamoun, Malek, Alejandro, Rodolfo, Bellin, Melena D., Chaloner, Kathryn, Czarniecki, Christine W., Goldstein, Julia S., Hering, Bernhard J., Hunsicker, Lawrence G., Kaufman, Dixon B., Korsgren, Olle, Larsen, Christian P., Luo, Xunrong, Naji, Ali, Oberholzer, José, Posselt, Andrew M., Ricordi, Camillo, Senior, Peter A., Shapiro, A. M. James, Stock, Peter G., Turgeon, Nicole A.

“…Allogeneic islet transplant offers a minimally invasive option for β cell replacement in the treatment of type 1 diabetes (T1D). The CIT consortium trial of…”
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Sulodexide for Kidney Protection in Type 2 Diabetes Patients With Microalbuminuria: A Randomized Controlled Trial by Lewis, Edmund J., MD, Lewis, Julia B., MD, Greene, Tom, PhD, Hunsicker, Lawrence G., MD, Berl, Tomas, MD, Pohl, Marc A., MD, de Zeeuw, Dick, MD, PhD, Heerspink, Hiddo Lambers, PhD, Rohde, Richard D., BS, Atkins, Robert C., MD, Reutens, Anne T., MD, Packham, David K., MD, Raz, Itamar, MD

“…Background Sulodexide, a heterogenous group of sulfated glycosaminoglycans, includes low-molecular-weight heparin (∼80% ± 8%), high-molecular-weight heparin…”
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Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial by Bansal, Nisha, Carpenter, Myra A, Weiner, Daniel E, Levey, Andrew S, Pfeffer, Marc, Kusek, John W, Cai, Jianwen, Hunsicker, Lawrence G, Park, Meyeon, Bennett, Michael, Liu, Kathleen D, Hsu, Chi-Yuan

“…Recipients of kidney transplants (KTR) are at increased risk for cardiovascular events, graft failure, and death. It is unknown whether urine kidney injury…”
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Renal Dysfunction in the Presence of Normoalbuminuria in Type 2 Diabetes: Results from the DEMAND Study by Dwyer, Jamie P., Parving, Hans-Henrik, Hunsicker, Lawrence G., Ravid, Moti, Remuzzi, Giuseppe, Lewis, Julia B.

“…Background/Aims: Microalbuminuria is associated with diabetes and is an independent risk factor for developing diabetic nephropathy. We have previously…”
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Impact of achieved blood pressure on cardiovascular outcomes in the irbesartan diabetic nephropathy trial by BERL, Tomas, HUNSICKER, Lawrence G, RAZ, Itamar, VANHILLE, Philippe, WIEGMANN, Thomas B, WOLFE, Bernard M, LOCATELLI, Francesco, GOLDHABER, Samuel Z, LEWIS, Edmund J, LEWIS, Julia B, PFEFFER, Marc A, PORUSH, Jerome G, ROULEAU, Jean-Lucien, DRURY, Paul L, ESMATJES, Enric, HRICIK, Donald, POHL, Marc

“…Elevated arterial pressure enhances the risk for cardiovascular (CV) events in patients with diabetic nephropathy. The optimal BP and the component of the…”
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The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy by Lewis, Edmund J, Hunsicker, Lawrence G, Bain, Raymond P, Rohde, Richard D

“…Patients with diabetic nephropathy have a progressive decline in glomerular function, and the treatment of hypertension in these patients slows the rate of…”
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The Effect of the Volume of Procedures at Transplantation Centers on Mortality after Liver Transplantation by Edwards, Erick B, Roberts, John P, McBride, Maureen A, Schulak, James A, Hunsicker, Lawrence G

“…Currently, organ transplantation is limited by the availability of donor organs. In the United States, there have been small increases in the number of donor…”
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A meta-analysis of GFR slope as a surrogate endpoint for kidney failure by Inker, Lesley A., Collier, Willem, Greene, Tom, Miao, Shiyuan, Chaudhari, Juhi, Appel, Gerald B., Badve, Sunil V., Caravaca-Fontán, Fernando, Del Vecchio, Lucia, Floege, Jürgen, Goicoechea, Marian, Haaland, Benjamin, Herrington, William G., Imai, Enyu, Jafar, Tazeen H., Lewis, Julia B., Li, Philip K. T., Maes, Bart D., Neuen, Brendon L., Perrone, Ronald D., Remuzzi, Giuseppe, Schena, Francesco P., Wanner, Christoph, Wetzels, Jack F. M., Woodward, Mark, Heerspink, Hiddo J. L.

“…Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a candidate surrogate endpoint for clinical trials of chronic kidney…”
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Pyridorin in Type 2 Diabetic Nephropathy by LEWIS, Edmund J, GREENE, Tom, YAGIL, Yoram, HERSKOVITS, Tommy, ATKINS, Robert C, REUTENS, Anne T, PACKHAM, David K, LEWIS, Julia B, SPITALEWIZ, Samuel, BLUMENTHAL, Samuel, BERL, Tomas, HUNSICKER, Lawrence G, POHL, Marc A, ROHDE, Richard D, RAZ, Itamar, YERUSHALMY, Yair

“…Pyridoxamine dihydrochloride (Pyridorin, NephroGenex) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic…”
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Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: The CIT-08 Study by Rickels, Michael R, Eggerman, Thomas L, Bayman, Levent, Qidwai, Julie C, Alejandro, Rodolfo, Bridges, Nancy D, Hering, Bernhard J, Markmann, James F, Senior, Peter A, Hunsicker, Lawrence G

“…To determine long-term outcomes for islet-alone and islet-after-kidney transplantation in adults with type 1 diabetes complicated by impaired awareness of…”
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361-OR: BETA-2 Score Is Highly Predictive of Graft Function after Islet Transplant: Analysis of Clinical Islet Transplant Consortium Trials by SENIOR, PETER A., RICKELS, MICHAEL R., EGGERMAN, THOMAS, BAYMAN, LEVENT, QIDWAI, JULIE, ALEJANDRO, RODOLFO, MARKMANN, JAMES F., HUNSICKER, LAWRENCE G.

“…The safety and efficacy of islet transplant for type 1 diabetes complicated by severe hypoglycemia was tested in a series of trials by the Clinical Islet…”
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358-OR: ß-Cell Function and Insulin Sensitivity with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation (CIT) Consortium by RICKELS, MICHAEL R., EGGERMAN, THOMAS, BAYMAN, LEVENT, QIDWAI, JULIE, NAJI, JOSEPH, NGUYEN, HUONG-LAN T., ALEJANDRO, RODOLFO, BELLIN, MELENA, SENIOR, PETER, HUNSICKER, LAWRENCE G.

“…Phase 3 studies of islet transplant alone (ITA) and islet-after-kidney (IAK) transplantation in type 1 diabetes were completed by the CIT Consortium using the…”
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Soluble CR1 Therapy Improves Complement Regulation in C3 Glomerulopathy by YUZHOU ZHANG, NESTER, Carla M, HOLANDA, Danniele G, MARSH, Henry C, HAMMOND, Russell A, THOMAS, Lawrence J, MEYER, Nicole C, HUNSICKER, Lawrence G, SETHI, Sanjeev, SMITH, Richard J. H

“…Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are widely recognized subtypes of C3 glomerulopathy. These ultra-rare renal diseases are…”
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Impact of Hyperuricemia on Long-term Outcomes of Kidney Transplantation: Analysis of the FAVORIT Study by Kalil, Roberto S., Carpenter, Myra A., Ivanova, Anastasia, Gravens-Mueller, Lisa, John, Alin A., Weir, Matthew R., Pesavento, Todd, Bostom, Andrew G., Pfeffer, Marc A., Hunsicker, Lawrence G.

“…Elevated uric acid concentration is associated with higher rates of cardiovascular (CV) morbidity and mortality in the general population. It is not known…”
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C-reactive protein as a predictor of total arteriosclerotic outcomes in type 2 diabetic nephropathy by Friedman, Allon N., Hunsicker, Lawrence G., Selhub, Jacob, Bostom, Andrew G.

“…C-reactive protein as a predictor of total arteriosclerotic outcomes in type 2 diabetic nephropathy. The inflammatory marker C-reactive protein (CRP) has been…”
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Extreme phenotype sampling and next generation sequencing to identify genetic variants associated with tacrolimus in African American kidney transplant recipients by Mohamed, Moataz E., Guo, Bin, Wu, Baolin, Schladt, David P., Muthusamy, Amutha, Guan, Weihua, Abrahante, Juan E., Onyeaghala, Guillaume, Saqr, Abdelrahman, Pankratz, Nathan, Agarwal, Gaurav, Mannon, Roslyn B., Matas, Arthur J., Oetting, William S., Remmel, Rory P., Israni, Ajay K., Jacobson, Pamala A., Dorr, Casey R.

“…African American (AA) kidney transplant recipients (KTRs) have poor outcomes, which may in-part be due to tacrolimus (TAC) sub-optimal immunosuppression. We…”
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A Controlled Trial of Plasmapheresis Therapy in Severe Lupus Nephritis by Lewis, Edmund J, Hunsicker, Lawrence G, Lan, Shu-Ping, Rohde, Richard D, Lachin, John M

“…THE mortality rate in patients with systemic lupus erythematosus and severe glomerulonephritis (lupus nephritis) is high. 1 2 3 In 1976 plasmapheresis was…”
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Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes by Lewis, Edmund J, Lewis, Julia B, Hunsicker, Lawrence G, Clarke, William R, Berl, Tomas, Pohl, Marc A, Ritz, Eberhard, Atkins, Robert C, Rohde, Richard, Raz, Itamar

“…Blockade of angiotensin type 1 receptors slows the progression of nephropathy. This effect is independent of the reduction in blood pressure. Diabetes mellitus…”
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Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial : Clinical implications and limitations by POHL, Marc A, BLUMENTHAL, Samuel, MANGILI, Ruggero, MOORE, Jack JR, REISIN, Efrain, RITZ, Eberhard, SCHEMTHANER, Guntram, SPITALEWITZ, Samuel, TINDALL, Hilary, RODBY, Roger A, LEWIS, Edmund J, CORDONNIER, Daniel J, DE ALVARO, Fernando, DEFERRARI, Giacomo, EISNER, Gilbert, ESMATJES, Enric, GILBERT, Richard E, HUNSICKER, Lawrence G, LOPES DE FARIA, Jose B

“…Elevated arterial pressure is a major risk factor for progression to ESRD in diabetic nephropathy. However, the component of arterial pressure and level of BP…”
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