Search Results - "Hunsberger, Joshua G"

Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder by Chiu, Chi-Tso, Wang, Zhifei, Hunsberger, Joshua G, Chuang, De-Maw

“…The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex…”
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An Industry‐Driven Roadmap for Manufacturing in Regenerative Medicine by Hunsberger, Joshua G., Shupe, Thomas, Atala, Anthony

“…Summary Regenerative medicine is poised to become a significant industry within the medical field. As such, the development of strategies and technologies for…”
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Accelerating stem cell trials for Alzheimer's disease by Hunsberger, Joshua G, PhD, Rao, Mahendra, Prof, Kurtzberg, Joanne, Prof, Bulte, Jeff W M, Prof, Atala, Anthony, Prof, LaFerla, Frank M, Prof, Greely, Henry T, Prof, Sawa, Akira, Prof, Gandy, Sam, Prof, Schneider, Lon S, Prof, Doraiswamy, P Murali, Prof

“…Summary At present, no effective cure or prophylaxis exists for Alzheimer's disease. Symptomatic treatments are modestly effective and offer only temporary…”
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kinesin signaling complex mediates the ability of GSK-3β to affect mood-associated behaviors by Du, Jing, Wei, Yanling, Liu, Lidong, Wang, Yun, Khairova, Rushaniya, Blumenthal, Rayah, Tragon, Tyson, Hunsberger, Joshua G, Machado-Vieira, Rodrigo, Drevets, Wayne, Wang, Yu Tian, Manji, Husseini K

“…Lithium has been the gold standard in the treatment of bipolar disorder (BPD) for 60 y. Like lithium, glycogen synthase kinase 3 (GSK-3) inhibitors display…”
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Recommendations for workforce development in regenerative medicine biomanufacturing by Green, Gary M., Read, Russ H., Lee, Sengyong, Tubon, Thomas, Hunsberger, Joshua G., Atala, Anthony

“…In its 2019 report, The Skilled Technical Workforce: Crafting America's Science and Engineering Enterprise, the National Science Board recommended a national…”
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MicroRNAs in Mental Health: From Biological Underpinnings to Potential Therapies by Hunsberger, Joshua G., Austin, Daniel R., Chen, Guang, Manji, Husseini K.

“…Psychiatric illnesses are disabling disorders with poorly understood underlying pathophysiologies. However, it is becoming increasingly evident that these…”
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Cellular mechanisms underlying affective resiliency: The role of glucocorticoid receptor- and mitochondrially-mediated plasticity by Hunsberger, Joshua G, Austin, Daniel R, Chen, Guang, Manji, Husseini K

“…Abstract Bipolar disorder (BPD) is a devastating psychiatric illness marked by recurrent episodes of mania and depression. While the underlying pathophysiology…”
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Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience by Hunsberger, Joshua G, Machado-Vieira, Rodrigo, Austin, Daniel R, Zarate, Carlos, Chuang, De-Maw, Chen, Guang, Reed, John C, Manji, Husseini K

“…Abstract The endoplasmic reticulum (ER) is a critical site for intracellular calcium storage as well as protein synthesis, folding, and trafficking. Disruption…”
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BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments by Maeng, Sungho, Hunsberger, Joshua G, Pearson, Brandon, Yuan, Peixiong, Wang, Yun, Wei, Yanling, McCammon, Joseph, Schloesser, Robert J, Zhou, Rulun, Du, Jing, Chen, Guang, McEwen, Bruce, Reed, John C, Manji, Husseini K

“…Recent microarray studies with stringent validating criteria identified Bcl-2-associated athanogene (BAG1) as a target for the actions of medications that are…”
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Evidence for Selective microRNAs and Their Effectors as Common Long-Term Targets for the Actions of Mood Stabilizers by Zhou, Rulun, Yuan, Peixiong, Wang, Yun, Hunsberger, Joshua G, Elkahloun, Abdel, Wei, Yanling, Damschroder-Williams, Patricia, Du, Jing, Chen, Guang, Manji, Husseini K

“…MicroRNAs (miRNAs) regulate messenger RNA (mRNA) translation in a sequence-specific manner and are emerging as critical regulators of central nervous system…”
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Antidepressant actions of the exercise-regulated gene VGF by Duman, Ronald S, Hunsberger, Joshua G, Newton, Samuel S, Bennett, Alicia H, Duman, Catharine H, Russell, David S, Salton, Stephen R

“…Exercise has many health benefits, including antidepressant actions in depressed human subjects, but the mechanisms underlying these effects have not been…”
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Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System by Hunsberger, Joshua G, Efthymiou, Anastasia G, Malik, Nasir, Behl, Mamta, Mead, Ivy L, Zeng, Xianmin, Simeonov, Anton, Rao, Mahendra

“…There is great need to develop more predictive drug discovery tools to identify new therapies to treat diseases of the central nervous system (CNS). Current…”
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Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia by Hunsberger, Joshua G, Fessler, Emily B, Wang, Zhifei, Elkahloun, Abdel G, Chuang, De-Maw

“…Stroke is a devastating brain injury that is a leading cause of adult disability with limited treatment options. Using a rat model of middle cerebral artery…”
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Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice by Omata, Naoto, Chiu, Chi-Tso, Moya, Pablo R., Leng, Yan, Wang, Zhifei, Hunsberger, Joshua G., Leeds, Peter, Chuang, De-Maw

“…Inhibition of glycogen synthase kinase-3 (GSK-3) by pharmacological tools can produce antidepressant-like effects in rodents. However, the GSK-3 isoform(s) and…”
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Concise Review: Modeling Central Nervous System Diseases Using Induced Pluripotent Stem Cells by Zeng, Xianmin, Hunsberger, Joshua G., Simeonov, Anton, Malik, Nasir, Pei, Ying, Rao, Mahendra

“…Induced pluripotent stem cells (iPSCs) represent a paradigm shift for central nervous system (CNS) disease modeling. Efforts in the field to develop more…”
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Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions by Hunsberger, Joshua G, Fessler, Emily B, Chibane, Fairouz L, Leng, Yan, Maric, Dragan, Elkahloun, Abdel G, Chuang, De-Maw

“…Identifying mechanisms to enhance neuroprotection holds tremendous promise in developing new treatments for neuropsychiatric and neurodegenerative diseases. We…”
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Five Critical Areas that Combat High Costs and Prolonged Development Times for Regenerative Medicine Manufacturing by Hunsberger, Joshua G., Goel, Sandeep, Allickson, Julie, Atala, Anthony

“…Purpose of Review The purpose of this review is to examine five stages of process improvement in bioengineering of cellular products that could facilitate…”
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Gene profiling the response to kainic acid induced seizures by Hunsberger, Joshua G., Bennett, Alica H., Selvanayagam, Emmanuel, Duman, Ronald S., Newton, Samuel S.

“…Kainic acid activates non- N-methyl- d-aspartate (NMDA) glutamate receptors where it increases synaptic activity resulting in seizures, neurodegeneration, and…”
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Regenerative Medicine Manufacturing—Challenges and Opportunities by Cohen, Paul, Hunsberger, Joshua G, Atala, Anthony

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Lentivirally mediated GSK-3[beta] silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice by Omata, Naoto, Chiu, Chi-Tso, Moya, Pablo R, Leng, Yan, Wang, Zhifei, Hunsberger, Joshua G, Leeds, Peter, Chuang, De-Maw

“…Abstract Inhibition of glycogen synthase kinase-3 (GSK-3) by pharmacological tools can produce antidepressant-like effects in rodents. However, the GSK-3…”
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