Sialochemical markers of salivary gland involvement with Sjögren's syndrome secondary to rheumatoid arthritis and primary biliary cirrhosis

: Sjögren’s syndrome is an autoimmune condition affecting the lacrimal and salivary glands and can be associated with rheumatoid arthritis and primary biliary cirrhosis. Parotid salivas collected from patients and normal controls were analysed for lactoferrin, IgA and beta2‐microglobulin (measured b...

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Bibliographic Details
Published in:	Journal of oral pathology & medicine Vol. 29; no. 9; pp. 452 - 459
Main Authors:	Carpenter, Guy H., Proctor, Gordon B., Pankhurst, Caroline L., O'Donohue, John, Scott, David, Hunnable, Mark P.
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Copenhagen Munksgaard International Publishers 01-10-2000 Blackwell
Subjects:	Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - metabolism beta 2-Microglobulin - analysis beta 2-Microglobulin - metabolism beta2-microglobulin Biological and medical sciences Case-Control Studies Connective Tissue Diseases - complications Connective Tissue Diseases - metabolism Cystatins - analysis Cystatins - metabolism Dentistry Humans IgA Immunoglobulin A, Secretory - analysis Immunoglobulin A, Secretory - metabolism lactoferrin Lactoferrin - analysis Lactoferrin - metabolism Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - metabolism Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Parotid Gland - metabolism Parotid Gland - secretion parotid saliva primary biliary cirrhosis rheumatoid arthritis Saliva - chemistry Saliva - secretion Salivary Proteins and Peptides - analysis Salivary Proteins and Peptides - metabolism Secretory Rate Sjogren's Syndrome - etiology Sjogren's Syndrome - metabolism Sjögren's syndrome Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Human Immunopathology Cystatin IgA Parotid gland Stomatology Diseases of the osteoarticular system Biological marker Hepatic disease Autoimmune disease Inflammatory joint disease Biliary cirrhosis Biliary tract disease Sjögren syndrome Eye disease Chronic Lactoferrin Rheumatoid arthritis Systemic disease Digestive diseases Complication Saliva β2-Microglobulin
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Summary:	: Sjögren’s syndrome is an autoimmune condition affecting the lacrimal and salivary glands and can be associated with rheumatoid arthritis and primary biliary cirrhosis. Parotid salivas collected from patients and normal controls were analysed for lactoferrin, IgA and beta2‐microglobulin (measured by ELISA), and cystatin (measured by a enzyme inhibition assay). Output data provided less variable means, whilst expressing results as a proportion of the total protein provided greater specificity as markers for Sjögren’s syndrome. Levels of specificity for IgA, lactoferrin and beta2‐microglobulin were all high (100, 95 and 100%, respectively). Sensitivity levels of these markers (but not cystatin) tended to be similar for Sjögren’s syndrome secondary to primary biliary cirrhosis (IgA, 25%; lactoferrin, 63%; and beta2‐microglobulin, 50%), compared to Sjögren’s syndrome secondary to connective tissue diseases such as rheumatoid arthritis (IgA, 50%; lactoferrin, 86%; and beta2‐microglobulin; 38%).
Bibliography:	istex:DBF8A7ABFC3FB62B0DC088BF168A743884C10C25 ArticleID:JOP290906 ark:/67375/WNG-961Z3J03-K ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0904-2512 1600-0714
DOI:	10.1034/j.1600-0714.2000.290906.x