Search Results - "Hungerford, William"

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma by Mazur, Marzena, Olczak, Jacek, Olejniczak, Sylwia, Koralewski, Robert, Czestkowski, Wojciech, Jedrzejczak, Anna, Golab, Jakub, Dzwonek, Karolina, Dymek, Barbara, Sklepkiewicz, Piotr L, Zagozdzon, Agnieszka, Noonan, Tom, Mahboubi, Keyvan, Conway, Bruce, Sheeler, Ryan, Beckett, Paul, Hungerford, William M, Podjarny, Alberto, Mitschler, Andre, Cousido-Siah, Alexandra, Fadel, Firas, Golebiowski, Adam

“…This article highlights our work toward the identification of a potent, selective, and efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational…”
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Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors by Arcari, Joel T., Beebe, Jean S., Berliner, Martin A., Bernardo, Vincent, Boehm, Merin, Borzillo, Gary V., Clark, Tracey, Cohen, Bruce D., Connell, Richard D., Frost, Heather N., Gordon, Deborah A., Hungerford, William M., Kakar, Shefali M., Kanter, Aaron, Keene, Nandell F., Knauth, Elizabeth A., LaGreca, Susan D., Lu, Yong, Martinez-Alsina, Louis, Marx, Matthew A., Morris, Joel, Patel, Nandini C., Savage, Doug, Soderstrom, Cathy I., Thompson, Carl, Tkalcevic, George, Tom, Norma J., Vajdos, Felix F., Valentine, James J., Vincent, Patrick W., Wessel, Matthew D., Chen, Jinshan M.

“…The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are…”
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Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E by Patridge, Eric V, Darnell, Alicia, Kucera, Kaury, Phillips, Gillian M, Bokesch, Heidi R, Gustafson, Kirk R, Spakowicz, Daniel J, Zhou, Linda, Hungerford, William M, Plummer, Mark, Hoyer, Denton, Narváez-Trujillo, Alexandra, Phillips, Andrew J, Strobel, Scott A

“…Natural products remain an important source of new therapeutics for emerging drug-resistant pathogens like Candida albicans, which particularly affects…”
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Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones—a novel class of HIF-hydroxylase inhibitors by Chang, Shang-Poa, Hungerford, William M., McDonald, Wayne S., Maguire, Robert J., Malony, Kelly Q., Subramanyam, Chakrapani

“…The synthesis of various substituted 2-pyridyl-5-cyano-pyrimidine-6-ones was accomplished via a three-step protocol. The key aspects of this parallel protocol…”
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The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer by Lippa, Blaise, Kauffman, Goss S., Arcari, Joel, Kwan, Tricia, Chen, Jinshan, Hungerford, William, Bhattacharya, Samit, Zhao, Xumiao, Williams, Courtney, Xiao, Jun, Pustilnik, Leslie, Su, Chunyan, Moyer, James D., Ma, Ling, Campbell, Mary, Steyn, Stefanus

“…The synthesis and biological evaluation of potent and selective inhibitors of the erbB2 kinase is presented. The vast majority of these compounds are found to…”
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High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development by Gihaz, Shalev, Gareiss, Peter, Choi, Jae-Yeon, Renard, Isaline, Pal, Anasuya Chattopadhyay, Surovsteva, Yulia, Chiu, Joy E., Thekkiniath, Jose, Plummer, Mark, Hungerford, William, Montgomery, Micaela L., Hosford, Alanah, Adams, Emily M., Lightfoot, Jorge D., Fox, David, Ojo, Kayode K., Staker, Bart L., Fuller, Kevin, Ben Mamoun, Choukri

“…Fungal infections are the leading cause of mortality by eukaryotic pathogens, with an estimated 150 million severe life-threatening cases and 1.7 million…”
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Targeting Pantothenate Kinase as an Effective Strategy for Antifungal Drug Development by Gihaz, Shalev, Gareiss, Peter, Choi, Jae‐Yeon, Renard, Isaline, Chattopadhyay Pal, Anasuya, Surovsteva, Yulia, Chiu, Joy E., Thekkiniath, Jose, Plummer, Mark, Hungerford, William, Montgomery, Micaela L., Hosford, Alanah, Adams, Emily M., Lightfoot, Jorge D., Fox, David, Ojo, Kayode K., Staker, Bart L., Fuller, Kevin, Ben Mamoun, Choukri

“…Fungal infections affect over one billion people worldwide each year and are the leading cause of mortality by eukaryotic pathogens with an estimated 150…”
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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function by Schiapparelli, Paula, Pirman, Natasha L., Mohler, Kyle, Miranda-Herrera, Pierre A., Zarco, Natanael, Kilic, Onur, Miller, Chad, Shah, Sagar R., Rogulina, Svetlana, Hungerford, William, Abriola, Laura, Hoyer, Denton, Turk, Benjamin E., Guerrero-Cázares, Hugo, Isaacs, Farren J., Quiñones-Hinojosa, Alfredo, Levchenko, Andre, Rinehart, Jesse

“…Advances in genetic code expansion have enabled the production of proteins containing site-specific, authentic post-translational modifications. Here, we use a…”
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YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors by Stachelek, Gregory C, Peterson-Roth, Elizabeth, Liu, Yanfeng, Fernandez, 3rd, Rafael J, Pike, Luke R G, Qian, Jack M, Abriola, Laura, Hoyer, Denton, Hungerford, William, Merkel, Janie, Glazer, Peter M

“…Radiotherapy and DNA-damaging chemotherapy are frequently utilized in the treatment of solid tumors. Innate or acquired resistance to these therapies remains a…”
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Short-acting 5-(trifluoromethyl)pyrido[4,3- d]pyrimidin-4(3 H)-one derivatives as orally-active calcium-sensing receptor antagonists by Didiuk, Mary T., Griffith, David A., Benbow, John W., Liu, Kevin K.C., Walker, Daniel P., Christopher Bi, F., Morris, Joel, Guzman-Perez, Angel, Gao, Hua, Bechle, Bruce M., Kelley, Ryan M., Yang, Xiaojing, Dirico, Kenneth, Ahmed, Syed, Hungerford, William, DiBrinno, Joseph, Zawistoski, Michael P., Bagley, Scott W., Li, Jianke, Zeng, Yuan, Santucci, Stephanie, Oliver, Robert, Corbett, Matthew, Olson, Thanh, Chen, Chiliu, Li, Mei, Paralkar, Vishwas M., Riccardi, Keith A., Healy, David R., Kalgutkar, Amit S., Maurer, Tristan S., Nguyen, Hang T., Frederick, Kosea S.

“…Structure–activity relationship studies, focused on the optimization of pharmacology and pharmacokinetics, are described for a series of short-acting…”
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BOCKSTEIN SPECTRA by HUNGERFORD, THOMAS WILLIAM

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Effects of Varying Time of Presenting Verbal Directions on Recall and Retention by Hungerford, Eugene William

“…This study investigated the effect of varying the time at which verbal directions are presented to students involved in a learning situation. Four randomly…”
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