Search Results - "Hung, Magdeleine"

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection by Salimzadeh, Loghman, Le Bert, Nina, Dutertre, Charles-A, Gill, Upkar S, Newell, Evan W, Frey, Christian, Hung, Magdeleine, Novikov, Nikolai, Fletcher, Simon, Kennedy, Patrick Tf, Bertoletti, Antonio

“…Chronic HBV (CHB) infection suppresses virus-specific T cells, but its impact on humoral immunity has been poorly analyzed. Here, we developed a dual-staining…”
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PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy by Bekerman, Elena, Hesselgesser, Joseph, Carr, Brian, Nagel, Mark, Hung, Magdeleine, Wang, Adele, Stapleton, Lance, von Gegerfelt, Agneta, Elyard, Hanne Andersen, Lifson, Jeffrey D, Geleziunas, Romas

“…Antiretroviral therapy (ART) limits human immunodeficiency virus 1 (HIV-1) replication but does not eliminate the long-lived reservoir established shortly…”
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Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes by Kornyeyev, Dmytro, Ramakrishnan, Dhivya, Voitenleitner, Christian, Livingston, Christine M, Xing, Weimei, Hung, Magdeleine, Kwon, Hyock Joo, Fletcher, Simon P, Beran, Rudolf K

“…The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses hepatitis B virus (HBV) transcription. HBV counters…”
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Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle by Chai, Ilean, Kornyeyev, Dmytro, Hsieh, Edward, Magombedze, Gesham, Stapleton, Lance, Hung, Magdeleine, Kwon, Hyock Joo, Stefanutti, Erin, Belzile, JeanPhilippe, Czerwieniec, Gregg, Wang, Adele Y., Morar, Mariya, Lad, Latesh

“…The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody…”
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HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys by Moldt, Brian, Chandrashekar, Abishek, Borducchi, Erica N, Nkolola, Joseph P, Stephenson, Heather, Nagel, Mark, Hung, Magdeleine, Goldsmith, Joshua, Pace, Craig S, Carr, Brian, Thomsen, Nathan D, Blair, Wade S, Geleziunas, Romas, Barouch, Dan H

“…A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using…”
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A Trimer of Dimers Is the Basic Building Block for Human Immunodeficiency Virus-1 Capsid Assembly by Tsiang, Manuel, Niedziela-Majka, Anita, Hung, Magdeleine, Jin, Debi, Hu, Eric, Yant, Stephen, Samuel, Dharmaraj, Liu, Xiaohong, Sakowicz, Roman

“…Human immunodeficiency virus-1 (HIV-1) capsid protein (CA) has become a target of antiviral drug design in recent years. The recognition that binding of small…”
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Large-scale functional purification of recombinant HIV-1 capsid by Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman

“…During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the…”
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Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance by Hung, Magdeleine, Tokarsky, E. John, Lagpacan, Leanna, Zhang, Lijun, Suo, Zucai, Lansdon, Eric B.

“…Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase…”
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Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors by Boyce, Sarah E, Tirunagari, Neeraj, Niedziela-Majka, Anita, Perry, Jason, Wong, Melanie, Kan, Elaine, Lagpacan, Leanna, Barauskas, Ona, Hung, Magdeleine, Fenaux, Martijn, Appleby, Todd, Watkins, William J, Schmitz, Uli, Sakowicz, Roman

“…Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these…”
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The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function by Hebner, Christy M, Han, Bin, Brendza, Katherine M, Nash, Michelle, Sulfab, Maisoun, Tian, Yang, Hung, Magdeleine, Fung, Wanchi, Vivian, Randall W, Trenkle, James, Taylor, James, Bjornson, Kyla, Bondy, Steven, Liu, Xiaohong, Link, John, Neyts, Johan, Sakowicz, Roman, Zhong, Weidong, Tang, Hengli, Schmitz, Uli

“…Tegobuvir (TGV) is a novel non-nucleoside inhibitor (NNI) of HCV RNA replication with demonstrated antiviral activity in patients with genotype 1 chronic HCV…”
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847 Pharmacokinetics and pharmacodynamics of GS-3583 in cynomolgus monkeys by Kuhne, Michelle, Chu, Hamlet, Clarke, Christopher, Carr, Brian, Baca, Manuel, Hung, Magdeleine, Nagel, Mark, Ambrogelly, Alexandre, Rajakumaraswamy, Nishanathan

“…BackgroundThe ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for…”
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846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy by Kuhne, Michelle, Chu, Hamlet, Ng, Sarah, Clarke, Christopher, Carr, Brian, Baca, Manuel, Hung, Magdeleine, Nagel, Mark, Ambrogelly, Alexandre, Wilson, Nicholas

“…BackgroundThe ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for…”
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Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly by Lad, Latesh, Clancy, Sheila, Koditek, David, Wong, Melanie H, Jin, Debi, Niedziela-Majka, Anita, Papalia, Giuseppe A, Hung, Magdeleine, Yant, Stephen, Somoza, John R, Hu, Eric, Chou, Chienhung, Tse, Winston, Halcomb, Randall, Sakowicz, Roman, Pagratis, Nikos

“…HIV capsid protein is an important target for antiviral drug design. High-throughput screening campaigns have identified two classes of compounds (PF74 and…”
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Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex by Tsiang, Manuel, Jones, Gregg S., Hung, Magdeleine, Mukund, Susmith, Han, Bin, Liu, Xiaohong, Babaoglu, Kerim, Lansdon, Eric, Chen, Xiaowu, Todd, Jacob, Cai, Terrence, Pagratis, Nikos, Sakowicz, Roman, Geleziunas, Romas

“…The interaction between lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF) and human immunodeficiency virus type 1 (HIV-1)…”
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The Balance between NRTI Discrimination and Excision Drives the Susceptibility of HIV-1 RT Mutants K65R, M184V and K65R+M184V by Ly, John K, Margot, Nicolas A, MacArthur, Holly L, Hung, Magdeleine, Miller, Michael D, White, Kirsten L

“…The HIV-1 reverse transcriptase (RT) resistance mutations K65R and M184V occur individually and in combination, and can contribute to decreased treatment…”
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Importance of Ribosomal Frameshifting for Human Immunodeficiency Virus Type 1 Particle Assembly and Replication by Hung, M, Patel, P, Davis, S, Green, S R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B by Le Bert, Nina, Salimzadeh, Loghman, Gill, Upkar Singh, Dutertre, Charles-Antoine, Facchetti, Floriana, Tan, Anthony, Hung, Magdeleine, Novikov, Nikolai, Lampertico, Pietro, Fletcher, Simon Paul, Kennedy, Patrick Thomas Francis, Bertoletti, Antonio

“…[Display omitted] •We developed a method for direct ex vivo visualization of HBV-specific B cells.•HBcAg- and HBsAg-specific B cells of patients with CHB…”
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Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV by Vanwolleghem, Thomas, Groothuismink, Zwier M.A., Kreefft, Kim, Hung, Magdeleine, Novikov, Nikolai, Boonstra, Andre

“…Little is known about the frequency, phenotype and function of HBV-specific B cells during chronic infection. Here we study HBcAg and HBsAg-specific B cells in…”
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Clinical targeting of HIV capsid protein with a long-acting small molecule by Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas

“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B by Daffis, Stephane, Balsitis, Scott, Chamberlain, Jason, Zheng, Jim, Santos, Rex, Rowe, William, Ramakrishnan, Dhivya, Pattabiraman, Divya, Spurlock, Sandra, Chu, Ruth, Kang, Don, Mish, Michael, Ramirez, Ricardo, Li, Li, Li, Bei, Ma, Sarina, Hung, Magdeleine, Voitenleitner, Christian, Yon, Changsuek, Suresh, Manasa, Menne, Stephan, Cote, Paul, Delaney, William E., Mackman, Richard, Fletcher, Simon P.

“…Background and Aims GS‐9688 (selgantolimod) is an oral selective small molecule agonist of toll‐like receptor 8 in clinical development for the treatment of…”
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