Search Results - "Hung, C. M."

The role of EZH2 in tumour progression by Chang, C-J, Hung, M-C

“…Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development…”
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Nuclear trafficking of the epidermal growth factor receptor family membrane proteins by Wang, Y-N, Yamaguchi, H, Hsu, J-M, Hung, M-C

“…Multiple membrane-bound receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR) and ErbB-2, have been reported to be localized in…”
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Mesenchymal stem cells promote growth and angiogenesis of tumors in mice by Huang, W-H, Chang, M-C, Tsai, K-S, Hung, M-C, Chen, H-L, Hung, S-C

“…Though the early integration of mesenchymal stem cells (MSCs) into tumor-associated stroma of cancer has been demonstrated, the functional contributions and…”
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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis by Martinez Calejman, C., Trefely, S., Entwisle, S. W., Luciano, A., Jung, S. M., Hsiao, W., Torres, A., Hung, C. M., Li, H., Snyder, N. W., Villén, J., Wellen, K. E., Guertin, D. A.

“…mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid…”
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Signaling cross-talk in the resistance to HER family receptor targeted therapy by Yamaguchi, H, Chang, S-S, Hsu, J L, Hung, M-C

“…Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) have an important role in the initiation and progression of various types of cancer. Inhibitors…”
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Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer by Chang, Y-W, Tseng, C-F, Wang, M-Y, Chang, W-C, Lee, C-C, Chen, L-T, Hung, M-C, Su, J-L

“…Heat-shock protein 5 (HSPA5) is a marker for poor prognosis in breast cancer patients and has an important role in cancer progression, including promoting drug…”
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Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival by Lo, H-W, Hung, M-C

“…Emerging evidences suggest the existence of a new mode of epidermal growth factor receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear…”
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EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer by Yamaguchi, H, Du, Y, Nakai, K, Ding, M, Chang, S-S, Hsu, J L, Yao, J, Wei, Y, Nie, L, Jiao, S, Chang, W-C, Chen, C-H, Yu, Y, Hortobagyi, G N, Hung, M-C

“…Inhibitors against poly (ADP-ribose) polymerase (PARP) are promising targeted agents currently used to treat BRCA -mutant ovarian cancer and are in clinical…”
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MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol by Yu, Y-H, Chen, H-A, Chen, P-S, Cheng, Y-J, Hsu, W-H, Chang, Y-W, Chen, Y-H, Jan, Y, Hsiao, M, Chang, T-Y, Liu, Y-H, Jeng, Y-M, Wu, C-H, Huang, M-T, Su, Y-H, Hung, M-C, Chien, M-H, Chen, C-Y, Kuo, M-L, Su, J-L

“…Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical…”
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Aurora A kinase activates YAP signaling in triple-negative breast cancer by Chang, S-S, Yamaguchi, H, Xia, W, Lim, S-O, Khotskaya, Y, Wu, Y, Chang, W-C, Liu, Q, Hung, M-C

“…The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in…”
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High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma by Ho, T H, Park, I Y, Zhao, H, Tong, P, Champion, M D, Yan, H, Monzon, F A, Hoang, A, Tamboli, P, Parker, A S, Joseph, R W, Qiao, W, Dykema, K, Tannir, N M, Castle, E P, Nunez-Nateras, R, Teh, B T, Wang, J, Walker, C L, Hung, M-C, Jonasch, E

“…Mutations in SETD2, a histone H3 lysine trimethyltransferase, have been identified in clear cell renal cell carcinoma (ccRCC); however it is unclear if loss of…”
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The role of the VEGF-C VEGFR-3 axis in cancer progression by SU, J.-L, YEN, C.-J, CHEN, P.-S, CHUANG, S.-E, HONG, C.-C, KUO, I.-H, CHEN, H.-Y, HUNG, M.-C, KUO, M.-L

“…Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer…”
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Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking by Du, Y, Shen, J, Hsu, J L, Han, Z, Hsu, M-C, Yang, C-C, Kuo, H-P, Wang, Y-N, Yamaguchi, H, Miller, S A, Hung, M-C

“…Receptor tyrosine kinases (RTKs) are cell surface receptors that initiate signal cascades in response to ligand stimulation. Abnormal expression and…”
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Effectiveness of mouth rinses against COVID-19: a systematic review and network meta-analysis by Lin, S-Y., Sun, J-S., Hung, M-C., Chang, J.Z-C.

“…This systematic review and network meta-analysis (NMA) comprehensively compared the effectiveness of different mouth rinses in reducing the viral…”
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Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR by Li, X, Lu, Y, Liang, K, Hsu, J-M, Albarracin, C, Mills, G B, Hung, M-C, Fan, Z

“…Epidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown…”
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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation by Liao, Y, Wei, Y, Zhou, X, Yang, J -Y, Dai, C, Chen, Y -J, Agarwal, N K, Sarbassov, D, Shi, D, Yu, D, Hung, M -C

“…The serine/threonine protein kinase B ( PKB , also known as Akt ) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has…”
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Linking genomic reorganization to tumor initiation via the giant cell cycle by Niu, N, Zhang, J, Zhang, N, Mercado-Uribe, I, Tao, F, Han, Z, Pathak, S, Multani, A S, Kuang, J, Yao, J, Bast, R C, Sood, A K, Hung, M-C, Liu, J

“…To investigate the mechanisms underlying our recent paradoxical finding that mitotically incapacitated and genomically unstable polyploid giant cancer cells…”
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Enhanced Piezoelectric and Dielectric Responses in 92.5%(Bi0.5Na0.5) TiO3 -7.5%BaTiO3 Ceramics by Anthoniappen, J., Lin, C.-H., Tu, C. S., Chen, P.-Y., Chen, C.-S., Chiu, S.-J., Lee, H.-Y., Wang, S.-F., Hung, C.-M.

“…Structure and piezoelectric coefficient (d33) of lead‐free 7.5% mole BaTiO3‐doped (Bi0.5Na0.5) TiO3 (BNT‐7.5%BT) polycrystalline piezoceramics have been…”
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Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer by Timsah, Z, Ahmed, Z, Ivan, C, Berrout, J, Gagea, M, Zhou, Y, Pena, G N A, Hu, X, Vallien, C, Kingsley, C V, Lu, Y, Hancock, J F, Liu, J, Gladden, A B, Mills, G B, Lopez-Berestein, G, Hung, M-C, Sood, A K, Bogdanov, M, Ladbury, J E

“…In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same…”
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Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells by Lin, C-Y, Chang, T-W, Hsieh, W-H, Hung, M-C, Lin, I-H, Lai, S-C, Tzeng, Y-J

“…Tanshinone IIA (Tan IIA), a constituent of the traditional medicinal plant Salvia miltiorrhiza BUNGE, has been reported to possess anticancer activity through…”
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