Search Results - "Hunden, David C."

Azetidinones as vasopressin V1a antagonists by Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D.G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.

“…The azetidinone LY307174 ( 1) was identified as a screening lead for the vasopressin V1a receptor (IC 50 45 nM at the human V1a receptor) based on molecular…”
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LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation by Felder, C C, Joyce, K E, Briley, E M, Glass, M, Mackie, K P, Fahey, K J, Cullinan, G J, Hunden, D C, Johnson, D W, Chaney, M O, Koppel, G A, Brownstein, M

“…LY320135 is a selective antagonist for the brain CB1 receptor, having greater than 70-fold higher affinity for the CB1 than the peripheral CB2 receptor. The Ki…”
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Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid by Kukolja, Stjepan, Draheim, Susan E, Graves, Bernard J, Hunden, David C, Pfeil, Janice L, Cooper, Robin D. G, Ott, John L, Counter, Fred T

“…Three positional analogues (4-, 5-, and 7-) of benzothienylglycine and (N-acetylindolinyl)-5-glycine were prepared and coupled to…”
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Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D by Whitesitt, Celia A., Simon, Richard L., Reel, Jon K., Sigmund, Sandra K., Phillips, Michael L., Kevin Shadle, J., Heinz, Lawrence J., Koppel, Gary A., Hunden, David C., Lifer, Sherryl L., Berry, Dennis, Ray, Judy, Little, Sheila P, Xiadong Liu, Marshall, Winston S., Panetta, Jill A.

“…Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and…”
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Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists by Siegel, Miles G., Chaney, Michael O., Bruns, Robert F., Clay, Michael P., Schober, Douglas A., Van Abbema, Anne M., Johnson, Douglas W., Cantrell, Buddy E., Hahn, Patric J., Hunden, David C., Gehlert, Donald R., Zarrinmayeh, Hamideh, Ornstein, Paul L., Zimmerman, Dennis M., Koppel, Gary A.

“…This study describes the integrated application of parallel synthesis and computational chemistry to the design of potent nonpeptide antagonists for the…”
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