Search Results - "Humpton, Timothy J."

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 by Tajan, Mylène, Hock, Andreas K., Blagih, Julianna, Robertson, Neil A., Labuschagne, Christiaan F., Kruiswijk, Flore, Humpton, Timothy J., Adams, Peter D., Vousden, Karen H.

“…Numerous mechanisms to support cells under conditions of transient nutrient starvation have been described. Several functions of the tumor-suppressor protein…”
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Regulation of Cellular Metabolism and Hypoxia by p53 by Humpton, Timothy J, Vousden, Karen H

“…The p53 protein is essential for the implementation of the cellular response to challenging environmental conditions. Reacting to stochastic nutrient stress,…”
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis by DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.

“…Radical role reversal Reactive oxygen species (ROS), such as free radicals, are mutagenic and might therefore be expected to promote tumorigenesis. However,…”
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Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop by Oliver, Trudy G., Meylan, Etienne, Chang, Gregory P., Xue, Wen, Burke, James R., Humpton, Timothy J., Hubbard, Diana, Bhutkar, Arjun, Jacks, Tyler

“…Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets are poorly understood. Caspase-2 is activated by the p53…”
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Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo by Hock, Andreas K., Cheung, Eric C., Humpton, Timothy J., Monteverde, Tiziana, Paulus-Hock, Viola, Lee, Pearl, McGhee, Ewan, Scopelliti, Alessandro, Murphy, Daniel J., Strathdee, Douglas, Blyth, Karen, Vousden, Karen H.

“…While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling…”
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p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant by Humpton, Timothy J, Hock, Andreas K, Maddocks, Oliver D K, Vousden, Karen H

“…In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping…”
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Aneuploidy Drives Genomic Instability in Yeast by Sheltzer, Jason M., Blank, Heidi M., Pfau, Sarah J., Tange, Yoshie, George, Benson M., Humpton, Timothy J., Brito, Ilana L., Hiraoka, Yasushi, Niwa, Osami, Amon, Angelika

“…Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by…”
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Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer by Humpton, Timothy J, Alagesan, Brinda, DeNicola, Gina M, Lu, Dan, Yordanov, Georgi N, Leonhardt, Carl S, Yao, Melissa A, Alagesan, Priya, Zaatari, Maya N, Park, Youngkyu, Skepper, Jeremy N, Macleod, Kay F, Perez-Mancera, Pedro A, Murphy, Michael P, Evan, Gerard I, Vousden, Karen H, Tuveson, David A

“…Activating mutations are found in nearly all cases of pancreatic ductal adenocarcinoma (PDAC), yet effective clinical targeting of oncogenic KRAS remains…”
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p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 by Humpton, Timothy J., Hall, Holly, Kiourtis, Christos, Nixon, Colin, Clark, William, Hedley, Ann, Shaw, Robin, Bird, Thomas G., Blyth, Karen, Vousden, Karen H.

“…The p53 transcription factor coordinates wide-ranging responses to stress that contribute to its function as a tumour suppressor. The responses to p53…”
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Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice by Humpton, Timothy J, Nomura, Koji, Weber, Julia, Magnussen, Helge M, Hock, Andreas K, Nixon, Colin, Dhayade, Sandeep, Stevenson, David, Huang, Danny T, Strathdee, Douglas, Blyth, Karen, Vousden, Karen H

“…The p53 tumor suppressor protein is a potent activator of proliferative arrest and cell death. In normal cells, this pathway is restrained by p53 protein…”
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A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo by Humpton, Timothy J, Hock, Andreas K, Kiourtis, Christos, De Donatis, Marco, Fercoq, Frédéric, Nixon, Colin, Bryson, Sheila, Strathdee, Douglas, Carlin, Leo M, Bird, Thomas G, Blyth, Karen, Vousden, Karen H

“…Genetically encoded probes are widely used to visualize cellular processes in vitro and in vivo. Although effective in cultured cells, fluorescent protein tags…”
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Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice by Humpton, Timothy J, Nomura, Koji, Weber, Julia, Magnussen, Helge M, Hock, Andreas K, Nixon, Colin, Dhayade, Sandeep, Stevenson, David, Huang, Danny T, Strathdee, Douglas, Blyth, Karen, Vousden, Karen H

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p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl 4 by Humpton, Timothy J, Hall, Holly, Kiourtis, Christos, Nixon, Colin, Clark, William, Hedley, Ann, Shaw, Robin, Bird, Thomas G, Blyth, Karen, Vousden, Karen H

“…The p53 transcription factor coordinates wide-ranging responses to stress that contribute to its function as a tumour suppressor. The responses to p53…”
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