Search Results - "Humphrys, Laura J."

Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium by Neumann, Joachim, Pockes, Steffen, Humphrys, Laura J., Mönnich, Denise, Forster, Lisa, Kirchhefer, Uwe, Hofmann, Britt, Gergs, Ulrich

“…Clonidine has various clinical effects mediated by agonism of α 1 - or α 2 -adrenoceptors and the blocking of hyperpolarization-activated-nucleotide-gated…”
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A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers by Kilpatrick, Laura E, Humphrys, Laura J, Holliday, Nicholas D

“…The ability of G protein-coupled receptors (GPCRs) to form dimers, and particularly heterodimers, offers potential for targeted therapeutics with improved…”
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[3H]UR-JG102–A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y4 Receptor by Gleixner, Jakob, Gattor, Albert O., Humphrys, Laura J., Brunner, Thomas, Keller, Max

“…The family of human neuropeptide Y receptors (YRs) comprises four subtypes (Y1R, Y2R, Y4R, and Y5R) that are involved in the regulation of numerous…”
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Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors by Gergs, Ulrich, Jacob, Hannes, Braekow, Pauline, Hofmann, Britt, Pockes, Steffen, Humphrys, Laura J., Kirchhefer, Uwe, Fehse, Charlotte, Neumann, Joachim

“…Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT 4 serotonin receptors and/or H 2 histamine…”
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Ergometrine stimulates histamine H2 receptors in the isolated human atrium by Jacob, Hannes, Braekow, Pauline, Hofmann, Britt, Kirchhefer, Uwe, Forster, Lisa, Mönnich, Denise, Humphrys, Laura J., Pockes, Steffen, Neumann, Joachim, Gergs, Ulrich

“…Ergometrine (6a R ,9 R )- N -(( S )-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3- fg ]chinolin-9-carboxamide or lysergide acid…”
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Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y 4 -Receptor by Plut, Eva, Calderón, Jacqueline C, Stanojlović, Vesna, Gattor, Albert O, Höring, Carina, Humphrys, Laura J, Konieczny, Adam, Kerres, Sabine, Schubert, Mario, Keller, Max, Cabrele, Chiara, Clark, Timothy, Reiser, Oliver

“…The G-protein-coupled Y -receptor (Y R) and its endogenous ligand, pancreatic polypeptide (PP), suppress appetite in response to food intake and, thus, are…”
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Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias by Schihada, Hannes, Klompstra, Thomas M., Humphrys, Laura J., Cervenka, Igor, Dadvar, Shamim, Kolb, Peter, Ruas, Jorge L., Schulte, Gunnar

“…Within the intestine, the human G protein–coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory bowel…”
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The dark sides of the GPCR tree - research progress on understudied GPCRs by Scharf, Magdalena M, Humphrys, Laura J, Berndt, Sandra, Di Pizio, Antonella, Lehmann, Juliane, Liebscher, Ines, Nicoli, Alessandro, Niv, Masha Y, Peri, Lior, Schihada, Hannes, Schulte, Gunnar

“…A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A…”
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Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y4‑Receptor by Plut, Eva, Calderón, Jacqueline C., Stanojlović, Vesna, Gattor, Albert O., Höring, Carina, Humphrys, Laura J., Konieczny, Adam, Kerres, Sabine, Schubert, Mario, Keller, Max, Cabrele, Chiara, Clark, Timothy, Reiser, Oliver

“…The G-protein-coupled Y4-receptor (Y4R) and its endogenous ligand, pancreatic polypeptide (PP), suppress appetite in response to food intake and, thus, are…”
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Dual Piperidine-Based Histamine H3 and Sigma‑1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain by Szczepańska, Katarzyna, Karcz, Tadeusz, Dichiara, Maria, Mogilski, Szczepan, Kalinowska-Tłuścik, Justyna, Pilarski, Bogusław, Leniak, Arkadiusz, Pietruś, Wojciech, Podlewska, Sabina, Popiołek-Barczyk, Katarzyna, Humphrys, Laura J., Ruiz-Cantero, M. Carmen, Reiner-Link, David, Leitzbach, Luisa, Łażewska, Dorota, Pockes, Steffen, Górka, Michał, Zmysłowski, Adam, Calmels, Thierry, Cobos, Enrique J., Marrazzo, Agostino, Stark, Holger, Bojarski, Andrzej J., Amata, Emanuele, Kieć-Kononowicz, Katarzyna

“…In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series of compounds structurally based on highly active in vivo ligands…”
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Dual Piperidine-Based Histamine H 3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain by Szczepańska, Katarzyna, Karcz, Tadeusz, Dichiara, Maria, Mogilski, Szczepan, Kalinowska-Tłuścik, Justyna, Pilarski, Bogusław, Leniak, Arkadiusz, Pietruś, Wojciech, Podlewska, Sabina, Popiołek-Barczyk, Katarzyna, Humphrys, Laura J, Ruiz-Cantero, M Carmen, Reiner-Link, David, Leitzbach, Luisa, Łażewska, Dorota, Pockes, Steffen, Górka, Michał, Zmysłowski, Adam, Calmels, Thierry, Cobos, Enrique J, Marrazzo, Agostino, Stark, Holger, Bojarski, Andrzej J, Amata, Emanuele, Kieć-Kononowicz, Katarzyna

“…In search of new dual-acting histamine H /sigma-1 receptor ligands, we designed a series of compounds structurally based on highly active ligands previously…”
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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor by Rosier, Niklas, Grätz, Lukas, Schihada, Hannes, Möller, Jan, Işbilir, Ali, Humphrys, Laura J, Nagl, Martin, Seibel, Ulla, Lohse, Martin J, Pockes, Steffen

“…The histamine H3 receptor (H3R) is considered an attractive drug target for various neurological diseases. We here report the synthesis of UR-NR266, a novel…”
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Activation of Multiple G Protein Pathways to Characterize the Five Dopamine Receptor Subtypes Using Bioluminescence Technology by Mönnich, Denise, Humphrys, Laura J., Höring, Carina, Hoare, Bradley L., Forster, Lisa, Pockes, Steffen

“…G protein-coupled receptors show preference for G protein subtypes but can recruit multiple G proteins with various downstream signaling cascades. This…”
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Illuminating Neuropeptide Y Y 4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools by Gleixner, Jakob, Kopanchuk, Sergei, Grätz, Lukas, Tahk, Maris-Johanna, Laasfeld, Tõnis, Veikšina, Santa, Höring, Carina, Gattor, Albert O, Humphrys, Laura J, Müller, Christoph, Archipowa, Nataliya, Köckenberger, Johannes, Heinrich, Markus R, Kutta, Roger Jan, Rinken, Ago, Keller, Max

“…The neuropeptide Y (NPY) Y receptor (Y R), a member of the family of NPY receptors, is physiologically activated by the linear 36-amino acid peptide pancreatic…”
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Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools by Gleixner, Jakob, Kopanchuk, Sergei, Grätz, Lukas, Tahk, Maris-Johanna, Laasfeld, Tõnis, Veikšina, Santa, Höring, Carina, Gattor, Albert O., Humphrys, Laura J., Müller, Christoph, Archipowa, Nataliya, Köckenberger, Johannes, Heinrich, Markus R., Kutta, Roger Jan, Rinken, Ago, Keller, Max

“…The neuropeptide Y (NPY) Y4 receptor (Y4R), a member of the family of NPY receptors, is physiologically activated by the linear 36-amino acid peptide…”
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[ 3 H]UR-JG102–A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y 4 Receptor by Gleixner, Jakob, Gattor, Albert O., Humphrys, Laura J., Brunner, Thomas, Keller, Max

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor by Rosier, Niklas, Grätz, Lukas, Schihada, Hannes, Möller, Jan, Işbilir, Ali, Humphrys, Laura J., Nagl, Martin, Seibel, Ulla, Lohse, Martin J., Pockes, Steffen

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Lysergic acid diethylamide stimulates cardiac human H 2 histamine and cardiac human 5-HT 4 -serotonin receptors by Gergs, Ulrich, Jacob, Hannes, Braekow, Pauline, Hofmann, Britt, Pockes, Steffen, Humphrys, Laura J, Kirchhefer, Uwe, Fehse, Charlotte, Neumann, Joachim

“…Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT serotonin receptors and/or H histamine…”
Get full text

Clonidine stimulates force of contraction via histamine H 2 receptors in the human atrium by Neumann, Joachim, Pockes, Steffen, Humphrys, Laura J, Mönnich, Denise, Forster, Lisa, Kirchhefer, Uwe, Hofmann, Britt, Gergs, Ulrich

“…Clonidine has various clinical effects mediated by agonism of α - or α -adrenoceptors and the blocking of hyperpolarization-activated-nucleotide-gated…”
Get full text

Ergometrine stimulates histamine H 2 receptors in the isolated human atrium by Jacob, Hannes, Braekow, Pauline, Hofmann, Britt, Kirchhefer, Uwe, Forster, Lisa, Mönnich, Denise, Humphrys, Laura J, Pockes, Steffen, Neumann, Joachim, Gergs, Ulrich

“…Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or…”
Get full text