Search Results - "Humphries, William H."
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Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells
Published in American journal of physiology. Renal physiology (01-02-2017)“…We have characterized the expression and secretion of the acute kidney injury (AKI) biomarkers insulin-like growth factor binding protein 7 (IGFBP7) and tissue…”
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Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran
Published in PloS one (24-10-2011)“…The endo-lysosomal pathway is essential for intracellular transport and the degradation of extracellular cargo. The relationship between three populations of…”
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Imaging lysosomal enzyme activity in live cells using self-quenched substrates
Published in Analytical biochemistry (15-05-2012)“…Endocytosis, the internalization and transport of extracellular cargo, is an essential cellular process. The ultimate step in endocytosis is the intracellular…”
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pH-Dependent cis → trans Isomerization Rates for Azobenzene Dyes in Aqueous Solution
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (26-11-2009)“…Azobenzenes can function as molecular switches driven by their unusual cis ↔ trans photoisomerization properties. The stability of an azobenzene-based switch…”
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Analyzing cell physiology in C. elegans with fluorescent ratiometric reporters
Published in Methods (San Diego, Calif.) (01-08-2014)“…Ratiometric fluorescent reporters have recently emerged a new technique to non-invasively measure aspects of cell physiology such as redox status, calcium…”
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Cellular binding, motion, and internalization of synthetic gene delivery polymers
Published in Biochimica et biophysica acta (01-10-2007)“…Using fluorescence microscopy we have tracked the cellular binding, surface motion, and internalization of polyarginine and polyethylenimine, cationic ligands…”
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Single particle tracking as a method to resolve differences in highly colocalized proteins
Published in Analyst (London) (07-09-2011)“…Single particle tracking fluorescence microscopy was used to study two late endosomal proteins, Rab7 and LAMP1, that appear to be highly colocalized in static…”
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P-Glycoprotein-Dependent Trafficking of Nanoparticle-Drug Conjugates
Published in Small (Weinheim an der Bergstrasse, Germany) (01-05-2014)Get full text
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Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy
Published in Integrative biology (Cambridge) (01-10-2010)“…The intracellular vesicle-mediated degradation of extracellular cargo is an essential cellular function. Using two-color single particle tracking fluorescence…”
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Pyrenebutyrate-Mediated Delivery of Quantum Dots across the Plasma Membrane of Living Cells
Published in The journal of physical chemistry. B (15-01-2009)“…Quantum dots have been delivered directly across the plasma membrane to the cytosol of living cells using a combination of a cationic peptide, polyarginine,…”
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Fluorescent Coumarin Thiols Measure Biological Redox Couples
Published in Organic letters (03-02-2012)“…In this report we present a new chemical probe, 3-HTC, that can reversibly and ratiometrically measure the thiol-disulfide equilibrium of biological systems…”
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Pyrenebutyrate-Mediated Delivery of Quantum Dots across the Plasma Membrane of Living Cells
Published in The journal of physical chemistry. B (05-08-2010)Get full text
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P‐Glycoprotein‐Dependent Trafficking of Nanoparticle‐Drug Conjugates
Published in Small (Weinheim an der Bergstrasse, Germany) (14-05-2014)“…P‐glycoprotein (P‐gp) is considered to be the most prevalent and single most important cause of multidrug‐resistance (MDR) in humans. Although the protein is…”
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Investigation of Lysosomes as Enzyme Storage Vesicles using Single Particle Tracking Fluorescence Microscopy
Published in Biophysical journal (01-02-2011)Get full text
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Dynamic Behavior of Intracellular Vesicles Probed with Two-Color Single Particle Tracking
Published in Biophysical journal (01-02-2011)Get full text
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Probing the Intracellular Reaction Dynamics of Low Density Lipoprotein Using Single Particle Tracking Fluorescence Microscopy
Published in Biophysical journal (01-02-2009)Get full text
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Late Endosomal Degradation of Low-Density Lipoprotein Probed with Multi-Color Single Particle Tracking Fluorescence Microscopy
Published in Biophysical journal (01-01-2010)Get full text
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Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopyElectronic supplementary information (ESI) available: Figures S1-S4. See DOI: 10.1039/c0ib00035c
Published 04-10-2010“…The intracellular vesicle-mediated degradation of extracellular cargo is an essential cellular function. Using two-color single particle tracking fluorescence…”
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