Search Results - "Humphries, Robert G"

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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Blockade of the Platelet P2Y12 Receptor by AR-C69931MX Sustains Coronary Artery Recanalization and Improves the Myocardial Tissue Perfusion in a Canine Thrombosis Model by Wang, Kai, Zhou, Xiaorong, Zhou, Zhongmin, Tarakji, Khaldoun, Carneiro, Marcelo, Penn, Marc S, Murray, Daniel, Klein, Allan, Humphries, Robert G, Turner, Jonathan, Thomas, James D, Topol, Eric J, Lincoff, A Michael

“…OBJECTIVE—Reperfusion therapy for myocardial infarction is limited by a significant reocclusion rate and less optimal myocardial tissue perfusion due to…”
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The C6‐2B glioma cell P2YAC receptor is pharmacologically and molecularly identical to the platelet P2Y12 receptor by Jin, Jianguo, Tomlinson, Wendy, Kirk, Ian P, Kim, Young B, Humphries, Robert G, Kunapuli, Satya P

“…P2Y receptor activation in many cell types leads to phospholipase C activation and accumulation of inositol phosphates, while in blood platelets, C6‐2B glioma…”
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Antagonists of the Platelet P 2T Receptor:  A Novel Approach to Antithrombotic Therapy by Ingall, Anthony H, Dixon, John, Bailey, Andrew, Coombs, Mandy E, Cox, David, McInally, Judith I, Hunt, Simon F, Kindon, Nicholas D, Teobald, Barry J, Willis, Paul A, Humphries, Robert G, Leff, Paul, Clegg, Jane A, Smith, James A, Tomlinson, Wendy

“…The platelet P 2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
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Antagonists of the Platelet P2T Receptor:  A Novel Approach to Antithrombotic Therapy by INGALL, Anthony H., DIXON, John, BAILEY, Andrew, COOMBS, Mandy E., COX, David, MCINALLY, Judith I., HUNT, Simon F., KINDON, Nicholas D., TEOBALD, Barry J., WILLIS, Paul A., HUMPHRIES, Robert G., LEFF, Paul, CLEGG, Jane A., SMITH, James A., TOMLINSON, Wendy

“…The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
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The C6‐2B glioma cell P2Y AC receptor is pharmacologically and molecularly identical to the platelet P2Y 12 receptor by Jin, Jianguo, Tomlinson, Wendy, Kirk, Ian P, Kim, Young B, Humphries, Robert G, Kunapuli, Satya P

“…P2Y receptor activation in many cell types leads to phospholipase C activation and accumulation of inositol phosphates, while in blood platelets, C6‐2B glioma…”
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Polarization and Dual-Wavelength Radar Observations of the Bright Band by Humphries, Robert G., Barge, Brian L.

“…Polarization and dual-wavelength radar data are presented for two days on which a radar bright band was observed. The polarization parameters (reflectivity,…”
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Preclinical and clinical studies with selective reversible direct P2Y12 antagonists by van Giezen, J J J, Humphries, Robert G

“…An important role for adenosine diphosphate (ADP)-induced platelet activation and aggregation was proposed more than 40 years ago. The clinical use of…”
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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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Blockade of the Platelet P2Y 12 Receptor by AR-C69931MX Sustains Coronary Artery Recanalization and Improves the Myocardial Tissue Perfusion in a Canine Thrombosis Model by Wang, Kai, Zhou, Xiaorong, Zhou, Zhongmin, Tarakji, Khaldoun, Carneiro, Marcelo, Penn, Marc S., Murray, Daniel, Klein, Allan, Humphries, Robert G., Turner, Jonathan, Thomas, James D., Topol, Eric J., Lincoff, A. Michael

“…Objective— Reperfusion therapy for myocardial infarction is limited by a significant reocclusion rate and less optimal myocardial tissue perfusion due to…”
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Identification of Rain and Hail with Circular Polarization Radar by Al-Jumily, Kais J., Charlton, Robert B., Humphries, Robert G.

“…This study integrates surface hail reports with concurrent radar measurements. It employs polarization techniques, corrected for propagation effects, to detect…”
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Workshop on Polarization Techniques in Radar Meteorology by Metcalf, James I., Humphries, Robert G.

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18th Conference on Radar Meteorology, AMS, 28–31 March 1978, Atlanta, Ga by Humphries, Robert G., Metcalf, James I.

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The relationship between development of ultraviolet erythema and release of prostaglandins in guinea pig skin by Adams, S S, Humphries, R G, Mason, C G

“…Ultraviolet erythema in the guinea pid has been in use for many years as a model for assessing the anti-inflammatory potency of non-steroidal anti-inflammatory…”
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