Search Results - "Humphries, R"

Hox genes in hematopoiesis and leukemogenesis by Argiropoulos, B, Humphries, R K

“…Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong…”
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Changes in the metallicity of gas giant planets due to pebble accretion by Humphries, R J, Nayakshin, S

“…Abstract We run numerical simulations to study the accretion of gas and dust grains on to gas giant planets embedded into massive protoplanetary discs. The…”
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Emerging Resistance, New Antimicrobial Agents... but No Tests! The Challenge of Antimicrobial Susceptibility Testing in the Current US Regulatory Landscape by Humphries, R. M., Hindler, J. A.

“…Accurate and timely performance of antimicrobial susceptibility testing (AST) by the clinical laboratory is paramount to combating antimicrobial resistance…”
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML by Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M

“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
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Fond Memories of Arthur W. Nienhuis, 1941–2021 by Karlsson, Stefan, Humphries, R. Keith

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Observations of Ice Nucleating Particles Over Southern Ocean Waters by McCluskey, C. S., Hill, T. C. J., Humphries, R. S., Rauker, A. M., Moreau, S., Strutton, P. G., Chambers, S. D., Williams, A. G., McRobert, I., Ward, J., Keywood, M. D., Harnwell, J., Ponsonby, W., Loh, Z. M., Krummel, P. B., Protat, A., Kreidenweis, S. M., DeMott, P. J.

“…A likely important feature of the poorly understood aerosol‐cloud interactions over the Southern Ocean (SO) is the dominant role of sea spray aerosol, versus…”
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The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML by Lin, Hanyang, Rothe, Katharina, Chen, Min, Wu, Andrew, Babaian, Artem, Yen, Ryan, Zeng, Jonathan, Ruschmann, Jens, Petriv, Oleh I., O'Neill, Kieran, Maetzig, Tobias, Knapp, David J.H.F., Nakamichi, Naoto, Brinkman, Ryan, Birol, Inanc, Forrest, Donna L., Hansen, Carl, Humphries, R. Keith, Eaves, Connie J., Jiang, Xiaoyan

“…Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in…”
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The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells by Copley, Michael R., Babovic, Sonja, Benz, Claudia, Knapp, David J. H. F., Beer, Philip A., Kent, David G., Wohrer, Stefan, Treloar, David Q., Day, Christopher, Rowe, Keegan, Mader, Heidi, Kuchenbauer, Florian, Humphries, R. Keith, Eaves, Connie J.

“…Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several properties, including a marked reduction in their self-renewal activity. We…”
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Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype by Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob

“…For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al . provide evidence that decreased expression of two miRNAs in…”
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Variability of Beta-Lactam Broth Microdilution for Pseudomonas aeruginosa by Bhalodi, A A, Oppermann, N, Campeau, S A, Humphries, R M

“…Antimicrobial susceptibility testing for Pseudomonas aeruginosa is critical to determine suitable treatment options. Commercial susceptibility tests are…”
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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin by Marra, Marco A, Morin, Ryan D, Johnson, Nathalie A, Severson, Tesa M, Mungall, Andrew J, An, Jianghong, Goya, Rodrigo, Paul, Jessica E, Boyle, Merrill, Woolcock, Bruce W, Kuchenbauer, Florian, Yap, Damian, Humphries, R Keith, Griffith, Obi L, Shah, Sohrab, Zhu, Henry, Kimbara, Michelle, Shashkin, Pavel, Charlot, Jean F, Tcherpakov, Marianna, Corbett, Richard, Tam, Angela, Varhol, Richard, Smailus, Duane, Moksa, Michelle, Zhao, Yongjun, Delaney, Allen, Qian, Hong, Birol, Inanc, Schein, Jacqueline, Moore, Richard, Holt, Robert, Horsman, Doug E, Connors, Joseph M, Jones, Steven, Aparicio, Samuel, Hirst, Martin, Gascoyne, Randy D

“…Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have…”
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In vitro and in vivo expansion of hematopoietic stem cells by Sauvageau, Guy, Iscove, Norman N, Humphries, R Keith

“…The capacity for sustained self-renewal--the generation of daughter cells having the same regenerative properties as the parent cell--is the defining feature…”
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Unexpectedly high ultrafine aerosol concentrations above East Antarctic sea ice by Humphries, R. S, Klekociuk, A. R, Schofield, R, Keywood, M, Ward, J, Wilson, S. R

“…Better characterisation of aerosol processes in pristine, natural environments, such as Antarctica, have recently been shown to lead to the largest reduction…”
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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation by Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., Aparicio, Samuel A.J.R.

“…Next-generation sequencing of follicular lymphoma and diffuse-large B-cell lymphoma has revealed frequent somatic, heterozygous Y641 mutations in the histone…”
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HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo by Antonchuk, Jennifer, Sauvageau, Guy, Humphries, R.Keith

“…Hox transcription factors have emerged as important regulators of primitive hematopoietic cell proliferation and differentiation. In particular, HOXB4 appears…”
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Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia by Mohr, Sebastian, Doebele, Carmen, Comoglio, Federico, Berg, Tobias, Beck, Julia, Bohnenberger, Hanibal, Alexe, Gabriela, Corso, Jasmin, Ströbel, Philipp, Wachter, Astrid, Beissbarth, Tim, Schnütgen, Frank, Cremer, Anjali, Haetscher, Nadine, Göllner, Stefanie, Rouhi, Arefeh, Palmqvist, Lars, Rieger, Michael A., Schroeder, Timm, Bönig, Halvard, Müller-Tidow, Carsten, Kuchenbauer, Florian, Schütz, Ekkehard, Green, Anthony R., Urlaub, Henning, Stegmaier, Kimberly, Humphries, R. Keith, Serve, Hubert, Oellerich, Thomas

“…The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore…”
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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia by Fisher, Cynthia L., Pineault, Nicolas, Brookes, Christy, Helgason, Cheryl D., Ohta, Hideaki, Bodner, Caroline, Hess, Jay L., Humphries, R. Keith, Brock, Hugh W.

“…The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is…”
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Multisite Evaluation of Cepheid Xpert Carba-R Assay for Detection of Carbapenemase-Producing Organisms in Rectal Swabs by Tato, M, Ruiz-Garbajosa, P, Traczewski, M, Dodgson, A, McEwan, A, Humphries, R, Hindler, J, Veltman, J, Wang, H, Cantón, R

“…Rapid identification of patients who are colonized with carbapenemase-producing organisms (CPO) is included in multiple national guidelines for containment of…”
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Aerosolisation during tracheal intubation and extubation in an operating theatre setting by Dhillon, R. S., Rowin, W. A., Humphries, R. S., Kevin, K., Ward, J. D., Phan, T. D., Nguyen, L. V., Wynne, D. D., Scott, D. A., Yule, A., Zhao, Y. C., McNeill, P. M., Hutchins, N.

“…Summary Aerosol‐generating procedures such as tracheal intubation and extubation pose a potential risk to healthcare workers because of the possibility of…”
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Equivalences between age structured models and state dependent distributed delay differential equations by Cassidy, Tyler, Craig, Morgan, Humphries, Antony R

“…We use the McKendrick equation with variable ageing rate and randomly distributed mat-uration time to derive a state dependent distributed delay differential…”
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