Search Results - "Humphries, Michael J"

The cost-effectiveness of brigatinib in adult patients with ALK inhibitor-naive ALK-positive non-small cell lung cancer from a US perspective by Cranmer, Holly, Kearns, Isabella, Young, Melanie, Humphries, Michael J, Trueman, David

“…The discovery of specific oncogenic drivers in non-small cell lung cancer (NSCLC) has led to the development of highly targeted anaplastic lymphoma kinase…”
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Real-world ALK Testing Trends in Patients With Advanced Non–Small-Cell Lung Cancer in the United States by Lin, Huamao M., Wu, Yanyu, Yin, Yu, Niu, Huifeng, Curran, Eileen A., Lovly, Christine M., Humphries, Michael J.

“…•Tumors from 73% of patients with advanced NSCLC were tested for ALK rearrangements in 2019.•Approximately 3 weeks passed between NSCLC diagnosis and ALK test…”
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Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ by DeVries-Seimon, Tracie A., Ohm, Angela M., Humphries, Michael J., Reyland, Mary E.

“…Protein kinase Cδ (PKCδ) mediates apoptosis downstream of many apoptotic stimuli. Because of its ubiquitous expression, tight regulation of the proapoptotic…”
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Regulated Binding of Importin-α to Protein Kinase Cδ in Response to Apoptotic Signals Facilitates Nuclear Import by Adwan, Tariq S., Ohm, Angela M., Jones, David N.M., Humphries, Michael J., Reyland, Mary E.

“…PKCδ translocates into the nucleus in response to apoptotic agents and functions as a potent cell death signal. Cytoplasmic retention of PKCδ and its transport…”
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Suppression of Apoptosis in the Protein Kinase Cδ Null Mouse in Vivo by Humphries, Michael J., Limesand, Kirsten H., Schneider, Jonathan C., Nakayama, Keiichi I., Anderson, Steven M., Reyland, Mary E.

“…Protein kinase C (PKC) δ is an essential regulator of mitochondrial dependent apoptosis in epithelial cells. We have used the PKCδ-/- mouse to ask if loss of…”
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Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis by Vogelmeier, Claus, Zhong, Nanshan, Humphries, Michael J, Mezzi, Karen, Fogel, Robert, Bader, Giovanni, Patalano, Francesco, Banerji, Donald

“…Indacaterol/glycopyrronium (IND/GLY) is approved for maintenance treatment of adult patients with COPD. This post hoc analysis explored the efficacy and safety…”
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Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo by Davies, Kurtis D, Humphries, Michael J, Sullivan, Francis X, von Carlowitz, Ira, Le Huerou, Yvan, Mohr, Peter J, Wang, Bin, Blake, James F, Lyon, Michael A, Gunawardana, Indrani, Chicarelli, Mark, Wallace, Eli, Gross, Stefan

“…Chk1 is a serine/threonine kinase that plays several important roles in the cellular response to genotoxic stress. Since many current standard-of-care…”
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Suppression of cell migration by protein kinase Cδ by JACKSON, Desmond, YANG ZHENG, LYO, Donggon, YINJIE SHEN, NAKAYAMA, Keiko, NAKAYAMA, Keiichi I, HUMPHRIES, Michael J, REYLAND, Mary E, FOSTER, David A

“…The ability of cancer cells to migrate is strongly correlated with malignant progression and metastasis. Survival signals that suppress apoptosis have also…”
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Salmeterol/Fluticasone Propionate in a Single Inhaler is Superior to Budesonide Alone in Control of Chinese Asthmatic Adults : An Open-Label, Randomised, 6-Week Study by Zhong, Nan Shan, Ping, Zheng Jin, Humphries, Michael J, Xin, Du

“…There is comparatively little information on asthma management in China. A multicentre, randomised, open-label, parallel-group, 6-week treatment study was…”
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ARRY-520 Combined With Pomalidomide Displays Enhanced Anti-Tumor Activity In Preclinical Models Of Multiple Myeloma by Humphries, Michael J, Anderson, Deborah, Williams, Lance, Rieger, Rob, Tunquist, Brian, Walker, Duncan

“…Inhibitors of Kinesin Spindle Protein (KSP), a mitosis-specific motor protein, represent a novel class of targeted anti-cancer therapies that have demonstrated…”
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Filanesib (ARRY-520) Demonstrates Potent and Rapid Activity in Preclinical Models of MM, Dependent on Bcl-2 Family Expression, and Synergistic with Dexamethasone and IMiDs by Hernández-García, Susana, San-Segundo, Laura, González-Méndez, Lorena, Paíno, Teresa, López-Iglesias, Ana Alicia, Martín-Sánchez, Montserrat, Garayoa, Mercedes, Humphries, Michael J, Tunquist, Brian, Mateos, Maria-Victoria, Ocio, Enrique M

“…Introduction: Multiple myeloma (MM) is characterized by the presence of complex karyotypes and chromosome instability, suggesting that cell cycle checkpoints…”
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Indacaterol/glycopyrronium in symptomatic patients with COPD by Humphries, Michael J, Fogel, Robert, Patalano, Francesco, Vogelmeier, Claus, Zhong, Nanshan, Banerji, Donald, Mezzi, Karen, Bader, Giovanni

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Indacaterol/glycopyrronium in symptomatic patients with COPD versus salmeterol/futicasone: ILLUMINATE/LANTERN pooled analysis by Vogelmeier, Claus, Zhong, Nanshan, Humphries, Michael J, Mezzi, Karen, Fogel, Robert, Bader, Giovanni, Patalano, Francesco, Banerji, Donald

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Efficacy of Dual Inhibition of p38 Mitogen Activated Protein Kinase (MAPK) and Tie-2 Kinase in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) by Shakaladevanapura Bachegowda, Lohith, Mantzaris, Ioannis, Morrone, Kerry A., Keshkar, Nandini, Li, Weijuan, Nwankwo, George, Shahnaz, Samira, Bhagat, Tushar D., Giricz, Orsolya, Bhattacharrya, Sanchari, Yu, Yiting, Schinke, Carolina D., Pynadath, Aby, Pellagatti, Andrea, Boultwood, Jacqueline, Humphries, Michael J, Winski, Shannon L, Bartenstein, Matthias, Guha, Chandan, Platanias, Leonidas, Steidl, Ulrich, Verma, Amit

“…Introduction- MDS and AML are hematologic malignancies that are characterized by malignant cell expansion and suppression of normal hematopoietic activity. An…”
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PKCδ Is Required for Mitochondrial-dependent Apoptosis in Salivary Epithelial Cells by Matassa, Angela A., Carpenter, Lee, Biden, Trevor J., Humphries, Michael J., Reyland, Mary E.

“…We report here that the novel protein kinase C isoform, PKCδ, is required at or prior to the level of the mitochondria for apoptosis induced by a diverse group…”
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Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase CÎ by Tracie A. DeVries-Seimon, Angela M. Ohm, Michael J. Humphries, Mary E. Reyland

“…Protein kinase Cδ (PKCδ) mediates apoptosis downstream of many apoptotic stimuli. Because of its ubiquitous expression, tight regulation of the proapoptotic…”
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Abstract 3874: Single-agent Chk1 inhibition is anti-proliferative in leukemia cells in vitro and in vivo by Davies, Kurtis D., Humphries, Michael J., Sullivan, Francis, von Carlowitz, Ira, Huerou, Yvan Le, Mohr, Peter J., Wang, Bin, Blake, Jim F., Lyon, Michael A., Gunawardana, Indrani, Chicarelli, Mark, Wallace, Eli, Gross, Stefan

“…Abstract Chk1 is a serine/threonine kinase that plays important roles in the cellular response to genotoxic stress. For this reason, there is a great deal of…”
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Abstract B254: Extended target-coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo by Humphries, Michael J., von Carlowitz, Ira, Le Huerou, Yvan, Randolph, Nikole, Mohr, Peter J., Wang, Bin, Lyon, Michael A., Gunawardana, Indrani, Chicarelli, Mark, Blake, Jim F., Schrag, Michael L., Winski, Shannon L., Wallace, Eli

“…Abstract Loss of coordination between cell cycle checkpoints and DNA damage repair is a fundamental feature tumor cells rely on for unregulated growth and…”
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Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy by Gross, Stefan D., Xu, Rui, Boys, Mark, Condroski, Kevin, DeMeese, Lisa, DeWolf, Walt E., Fell, Brad, Fischer, John, Gloor, Susan, Humphries, Michael J., Miknis, Greg, Regal, Kelly, Rodriguez, Mareli, Raddatz, Nicholas, Shotts, Kristin, Topalov, Georg, Wallace, Eli, Zuzack, John, Josey, John A., Winkler, James, Koch, Kevin

“…Abstract As a consequence of a variety of genetic lesions, the PI3K/Akt pathway is constitutively activated in a large proportion of human cancers. The mTOR…”
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Suppression of Apoptosis in the Protein Kinase Cδ Null Mouse in Vivo by Michael J. Humphries, Kirsten H. Limesand, Jonathan C. Schneider, Keiichi I. Nakayama, Steven M. Anderson, Mary E. Reyland

“…Protein kinase C (PKC) δ is an essential regulator of mitochondrial dependent apoptosis in epithelial cells. We have used the PKCδ -/- mouse to ask if loss…”
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