Search Results - "Humphries, Lisa A."

Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells by Silva, Oscar, Crocetti, Jillian, Humphries, Lisa A, Burkhardt, Janis K, Miceli, M Carrie

“…Functionally diverse CD8+ T cells develop in response to antigenic stimulation with differing capacities to couple TCR engagement to downstream signals and…”
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Characterization of in vivo Dlg1 deletion on T cell development and function by Humphries, Lisa A, Shaffer, Meredith H, Sacirbegovic, Faruk, Tomassian, Tamar, McMahon, Kerrie-Ann, Humbert, Patrick O, Silva, Oscar, Round, June L, Takamiya, Kogo, Huganir, Richard L, Burkhardt, Janis K, Russell, Sarah M, Miceli, M Carrie

“…The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated…”
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Calcium signalling and cell-fate choice in B cells by Scharenberg, Andrew M, Rawlings, David J, Humphries, Lisa A

“…Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is crucial for the development and function of B cells. Cytosolic…”
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Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors by Miceli, M Carrie, Round, June L, Humphries, Lisa A, Tomassian, Tamar, Mittelstadt, Paul, Zhang, Min

“…Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely…”
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Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells by Tomassian, Tamar, Humphries, Lisa A, Liu, Scot D, Silva, Oscar, Brooks, David G, Miceli, M Carrie

“…TCR engagement triggers the polarized recruitment of membrane, actin, and transducer assemblies within the T cell-APC contact that amplify and specify…”
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Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells by Crocetti, Jillian, Silva, Oscar, Humphries, Lisa A, Tibbs, Michelle D, Miceli, M Carrie

“…CD8(+) T cells respond to TCR stimulation by producing proinflammatory cytokines, and destroying infected or malignant cells through the production and release…”
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BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity by Saito, Kan, Tolias, Kimberley F, Saci, Abdelhafid, Koon, Henry B, Humphries, Lisa A, Scharenberg, Andrew, Rawlings, David J, Kinet, Jean-Pierre, Carpenter, Christopher L

“…Intracellular signaling by most cell surface receptors requires the generation of two major second messengers, phosphatidylinositol-3,4,5-trisphosphate…”
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PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling by Rawlings, David J, Su, Thomas T, Guo, Beichu, Kawakami, Yuko, Sommer, Karen, Chae, Keun, Humphries, Lisa A, Kato, Roberta M, Kang, Shin, Patrone, Lisa, Wall, Randolph, Teitell, Michael, Leitges, Michael, Kawakami, Toshiaki

“…NF-kappa B signaling is required for the maintenance of normal B lymphocytes, whereas dysregulated NF-kappa B activation contributes to B cell lymphomas. The…”
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A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation by Clayton, Elizabeth, Bardi, Giuseppe, Bell, Sarah E., Chantry, David, Downes, C. Peter, Gray, Alexander, Humphries, Lisa A., Rawlings, David, Reynolds, Helen, Vigorito, Elena, Turner, Martin

“…Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum…”
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Tec Kinases Mediate Sustained Calcium Influx via Site-specific Tyrosine Phosphorylation of the Phospholipase Cγ Src Homology 2-Src Homology 3 Linker by Humphries, Lisa A., Dangelmaier, Carol, Sommer, Karen, Kipp, Kevin, Kato, Roberta M., Griffith, Natasha, Bakman, Irene, Turk, Christoph W., Daniel, James L., Rawlings, David J.

“…Tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) is a crucial activation switch that initiates and maintains intracellular calcium mobilization in…”
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CD38 Signaling Regulates B Lymphocyte Activation via a Phospholipase C (PLC)-γ2-Independent, Protein Kinase C, Phosphatidylcholine-PLC, and Phospholipase D-Dependent Signaling Cascade by Moreno-García, Miguel E., López-Bojórques, Lucia N., Zentella, Alejandro, Humphries, Lisa A., Rawlings, David J., Santos-Argumedo, Leopoldo

“…The CD38 cell surface receptor is a potent activator for splenic, B lymphocytes. The molecular mechanisms regulating this response, however, remain…”
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Discs Large Homolog 1 Splice Variants Regulate p38 -Dependent and -Independent Effector Functions in CD8+ T Cells: e0133353 by Silva, Oscar, Crocetti, Jillian, Humphries, Lisa A, Burkhardt, Janis K, Miceli, M Carrie

“…Functionally diverse CD8+ T cells develop in response to antigenic stimulation with differing capacities to couple TCR engagement to downstream signals and…”
Get full text

CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade by Moreno-García, Miguel E, López-Bojórques, Lucia N, Zentella, Alejandro, Humphries, Lisa A, Rawlings, David J, Santos-Argumedo, Leopoldo

“…The CD38 cell surface receptor is a potent activator for splenic, B lymphocytes. The molecular mechanisms regulating this response, however, remain…”
Get full text

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors by Round, June L, Humphries, Lisa A, Tomassian, Tamar, Mittelstadt, Paul, Zhang, Min, Miceli, M Carrie

“…Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely…”
Get full text

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-[kappa]B transcription factors by Round, June L, Humphries, Lisa A, Tomassian, Tamar, Mittelstadt, Paul, Zhang, Min, Miceli, M Carrie

“…Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely…”
Get full text

Tec Kinases Mediate Sustained Calcium Influx via Site-specific Tyrosine Phosphorylation of the Phospholipase Cγ Src Homology 2-Src Homology 3 Linker by Lisa A. Humphries, Carol Dangelmaier, Karen Sommer, Kevin Kipp, Roberta M. Kato, Natasha Griffith, Irene Bakman, Christoph W. Turk, James L. Daniel, David J. Rawlings

“…Tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) is a crucial activation switch that initiates and maintains intracellular calcium mobilization in…”
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Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker by Humphries, Lisa A, Dangelmaier, Carol, Sommer, Karen, Kipp, Kevin, Kato, Roberta M, Griffith, Natasha, Bakman, Irene, Turk, Christoph W, Daniel, James L, Rawlings, David J

“…Tyrosine phosphorylation of phospholipase Cgamma2 (PLCgamma2) is a crucial activation switch that initiates and maintains intracellular calcium mobilization in…”
Get full text

BTK Regulates PtdIns-4,5-P2 Synthesis by Saito, Kan, Tolias, Kimberley F, Saci, Abdelhafid, Koon, Henry B, Humphries, Lisa A, Scharenberg, Andrew, Rawlings, David J, Kinet, Jean-Pierre, Carpenter, Christopher L

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BTK Regulates PtdIns-4,5-P 2 Synthesis : Importance for Calcium Signaling and PI3K Activity by Saito, Kan, Tolias, Kimberley F, Saci, Abdelhafid, Koon, Henry B, Humphries, Lisa A, Scharenberg, Andrew, Rawlings, David J, Kinet, Jean-Pierre, Carpenter, Christopher L

“…Intracellular signaling by most cell surface receptors requires the generation of two major second messengers, phosphatidylinositol-3,4,5-trisphosphate…”
Get full text

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation by Clayton, Elizabeth, Bardi, Giuseppe, Bell, Sarah E, Chantry, David, Downes, C Peter, Gray, Alexander, Humphries, Lisa A, Rawlings, David, Reynolds, Helen, Vigorito, Elena, Turner, Martin

“…Mice lacking the p110delta catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum…”
Get full text