Search Results - "Humphries, Keith R."

The methyltransferase G9a regulates HoxA9-dependent transcription in AML by Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M

“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
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The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells by Copley, Michael R., Babovic, Sonja, Benz, Claudia, Knapp, David J. H. F., Beer, Philip A., Kent, David G., Wohrer, Stefan, Treloar, David Q., Day, Christopher, Rowe, Keegan, Mader, Heidi, Kuchenbauer, Florian, Humphries, R. Keith, Eaves, Connie J.

“…Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several properties, including a marked reduction in their self-renewal activity. We…”
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Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype by Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob

“…For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al . provide evidence that decreased expression of two miRNAs in…”
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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin by Marra, Marco A, Morin, Ryan D, Johnson, Nathalie A, Severson, Tesa M, Mungall, Andrew J, An, Jianghong, Goya, Rodrigo, Paul, Jessica E, Boyle, Merrill, Woolcock, Bruce W, Kuchenbauer, Florian, Yap, Damian, Humphries, R Keith, Griffith, Obi L, Shah, Sohrab, Zhu, Henry, Kimbara, Michelle, Shashkin, Pavel, Charlot, Jean F, Tcherpakov, Marianna, Corbett, Richard, Tam, Angela, Varhol, Richard, Smailus, Duane, Moksa, Michelle, Zhao, Yongjun, Delaney, Allen, Qian, Hong, Birol, Inanc, Schein, Jacqueline, Moore, Richard, Holt, Robert, Horsman, Doug E, Connors, Joseph M, Jones, Steven, Aparicio, Samuel, Hirst, Martin, Gascoyne, Randy D

“…Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have…”
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The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML by Lin, Hanyang, Rothe, Katharina, Chen, Min, Wu, Andrew, Babaian, Artem, Yen, Ryan, Zeng, Jonathan, Ruschmann, Jens, Petriv, Oleh I., O'Neill, Kieran, Maetzig, Tobias, Knapp, David J.H.F., Nakamichi, Naoto, Brinkman, Ryan, Birol, Inanc, Forrest, Donna L., Hansen, Carl, Humphries, R. Keith, Eaves, Connie J., Jiang, Xiaoyan

“…Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in…”
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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation by Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., Aparicio, Samuel A.J.R.

“…Next-generation sequencing of follicular lymphoma and diffuse-large B-cell lymphoma has revealed frequent somatic, heterozygous Y641 mutations in the histone…”
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Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia by Mohr, Sebastian, Doebele, Carmen, Comoglio, Federico, Berg, Tobias, Beck, Julia, Bohnenberger, Hanibal, Alexe, Gabriela, Corso, Jasmin, Ströbel, Philipp, Wachter, Astrid, Beissbarth, Tim, Schnütgen, Frank, Cremer, Anjali, Haetscher, Nadine, Göllner, Stefanie, Rouhi, Arefeh, Palmqvist, Lars, Rieger, Michael A., Schroeder, Timm, Bönig, Halvard, Müller-Tidow, Carsten, Kuchenbauer, Florian, Schütz, Ekkehard, Green, Anthony R., Urlaub, Henning, Stegmaier, Kimberly, Humphries, R. Keith, Serve, Hubert, Oellerich, Thomas

“…The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore…”
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High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays by Lecault, Véronique, VanInsberghe, Michael, Sekulovic, Sanja, Knapp, David J H F, Wohrer, Stefan, Bowden, William, Viel, Francis, McLaughlin, Thomas, Jarandehei, Asefeh, Miller, Michelle, Falconnet, Didier, White, Adam K, Kent, David G, Copley, Michael R, Taghipour, Fariborz, Eaves, Connie J, Humphries, R Keith, Piret, James M, Hansen, Carl L

“…A microfluidic setup for nanoliter-volume perfused clonal culture and imaging of thousands of nonadherent cells is applied to study signaling and proliferation…”
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Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression by Coulombe, Patrick, Cole, Grace, Fentiman, Amanda, Parker, Jeremy D. K., Yung, Eric, Bilenky, Misha, Degefie, Lemlem, Lac, Patrick, Ling, Maggie Y. M., Tam, Derek, Humphries, R. Keith, Karsan, Aly

“…Hematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization of early…”
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Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia by Bhayadia, Raj, Krowiorz, Kathrin, Haetscher, Nadine, Jammal, Razan, Emmrich, Stephan, Obulkasim, Askar, Fiedler, Jan, Schwarzer, Adrian, Rouhi, Arefeh, Heuser, Michael, Wingert, Susanne, Bothur, Sabrina, Döhner, Konstanze, Mätzig, Tobias, Ng, Michelle, Reinhardt, Dirk, Döhner, Hartmut, Zwaan, C Michel, van den Heuvel Eibrink, Marry, Heckl, Dirk, Fornerod, Maarten, Thum, Thomas, Humphries, R Keith, Rieger, Michael A, Kuchenbauer, Florian, Klusmann, Jan-Henning

“…Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness of acute myeloid leukemia (AML). We describe the effect of the…”
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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia by Fisher, Cynthia L., Pineault, Nicolas, Brookes, Christy, Helgason, Cheryl D., Ohta, Hideaki, Bodner, Caroline, Hess, Jay L., Humphries, R. Keith, Brock, Hugh W.

“…The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is…”
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Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML by Garg, Swati, Reyes-Palomares, Armando, He, Lixiazi, Bergeron, Anne, Lavallée, Vincent-Philippe, Lemieux, Sébastien, Gendron, Patrick, Rohde, Christian, Xia, Jianglong, Jagdhane, Prarabdha, Müller-Tidow, Carsten, Lipka, Daniel B., Imren, Suzan, Humphries, R. Keith, Waskow, Claudia, Vick, Binje, Jeremias, Irmela, Richard-Carpentier, Guillaume, Hébert, Josée, Sauvageau, Guy, Zaugg, Judith B., Barabé, Frédéric, Pabst, Caroline

“…FLT3, DNMT3A, and NPM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is known about how these…”
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Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia by Kloos, Arnold, Mintzas, Konstantinos, Winckler, Lina, Gabdoulline, Razif, Alwie, Yasmine, Jyotsana, Nidhi, Kattre, Nadine, Schottmann, Renate, Scherr, Michaela, Gupta, Charu, Adams, Felix F., Schwarzer, Adrian, Heckl, Dirk, Schambach, Axel, Imren, Suzan, Humphries, R. Keith, Ganser, Arnold, Thol, Felicitas, Heuser, Michael

“…To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML…”
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Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma by Lee, Hae-Ri, Lee, Ga-Young, Kim, Eung-Won, Kim, Hee-Je, Lee, Minho, Humphries, R Keith, Oh, Il-Hoan

“…Chemoresistance of leukemic cells has largely been attributed to clonal evolution secondary to accumulating mutations. Here, we show that a subset of leukemic…”
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Clonal Analysis via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells by Nguyen, Long V., Makarem, Maisam, Carles, Annaick, Moksa, Michelle, Kannan, Nagarajan, Pandoh, Pawan, Eirew, Peter, Osako, Tomo, Kardel, Melanie, Cheung, Alice M.S., Kennedy, William, Tse, Kane, Zeng, Thomas, Zhao, Yongjun, Humphries, R. Keith, Aparicio, Samuel, Eaves, Connie J., Hirst, Martin

“…Cellular barcoding offers a powerful approach to characterize the growth and differentiation activity of large numbers of cotransplanted stem cells. Here, we…”
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Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis by Argiropoulos, Bob, Yung, Eric, Humphries, R Keith

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Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis by Rawat, Vijay P.S., Humphries, R. Keith, Buske, Christian

“…During the past decade it was recognized that homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignant…”
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In vitro and in vivo expansion of hematopoietic stem cells by Sauvageau, Guy, Iscove, Norman N, Humphries, R Keith

“…The capacity for sustained self-renewal--the generation of daughter cells having the same regenerative properties as the parent cell--is the defining feature…”
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A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis by Berg, Tobias, Thoene, Silvia, Yap, Damian, Wee, Tracee, Schoeler, Nathalie, Rosten, Patty, Lim, Emilia, Bilenky, Misha, Mungall, Andrew J., Oellerich, Thomas, Lee, Sherry, Lai, Courteney K., Umlandt, Patricia, Salmi, Anisa, Chang, Harry, Yue, Lisa, Lai, David, Cheng, S.-W. Grace, Morin, Ryan D., Hirst, Martin, Serve, Hubert, Marra, Marco A., Morin, Gregg B., Gascoyne, Randy D., Aparicio, Samuel A., Humphries, R. Keith

“…The histone methyltransferase EZH2 is frequently mutated in germinal center–derived diffuse large B-cell lymphoma and follicular lymphoma. To further…”
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Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations by Starczynowski, Daniel T., Morin, Ryan, McPherson, Andrew, Lam, Jeff, Chari, Raj, Wegrzyn, Joanna, Kuchenbauer, Florian, Hirst, Martin, Tohyama, Kaoru, Humphries, R. Keith, Lam, Wan L., Marra, Marco, Karsan, Aly

“…Cytogenetic alterations, such as amplifications, deletions, or translocations, contribute to myeloid malignancies. MicroRNAs (miRNAs) have emerged as critical…”
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