Search Results - "Humphries, J"

Integrin structure, activation, and interactions by Campbell, Iain D, Humphries, Martin J

“…Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a metazoan existence. All members of the integrin family adopt a shape…”
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Signal transduction via integrin adhesion complexes by Humphries, Jonathan D, Chastney, Megan R, Askari, Janet A, Humphries, Martin J

“…Integrin adhesion complexes (IACs) have evolved over millions of years to integrate metazoan cells physically with their microenvironment. It is presumed that…”
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Connections between the cell cycle, cell adhesion and the cytoskeleton by Jones, Matthew C, Zha, Junzhe, Humphries, Martin J

“…Cell division, the purpose of which is to enable cell replication, and in particular to distribute complete, accurate copies of genetic material to daughter…”
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Changes in the metallicity of gas giant planets due to pebble accretion by Humphries, R J, Nayakshin, S

“…Abstract We run numerical simulations to study the accretion of gas and dust grains on to gas giant planets embedded into massive protoplanetary discs. The…”
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On the origin of wide-orbit ALMA planets: giant protoplanets disrupted by their cores by Humphries, J, Nayakshin, S

“…ABSTRACT Recent ALMA observations may indicate a surprising abundance of sub-Jovian planets on very wide orbits in protoplanetary discs that are only a few…”
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Cell adhesion is regulated by CDK1 during the cell cycle by Jones, Matthew C, Askari, Janet A, Humphries, Jonathan D, Humphries, Martin J

“…In most tissues, anchorage-dependent growth and cell cycle progression are dependent on cells engaging extracellular matrices (ECMs) via integrin-receptor…”
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Proteomic definitions of basement membrane composition in health and disease by Randles, Michael J., Humphries, Martin J., Lennon, Rachel

“…Basement membranes are formed from condensed networks of extracellular matrix (ECM) proteins. These structures underlie all epithelial, mesothelial and…”
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Clathrin-containing adhesion complexes by Lock, John G, Baschieri, Francesco, Jones, Matthew C, Humphries, Jonathan D, Montagnac, Guillaume, Strömblad, Staffan, Humphries, Martin J

“…An understanding of the mechanisms whereby cell adhesion complexes (ACs) relay signals bidirectionally across the plasma membrane is necessary to interpret the…”
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The integrin adhesome network at a glance by Horton, Edward R, Humphries, Jonathan D, James, Jenny, Jones, Matthew C, Askari, Janet A, Humphries, Martin J

“…The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between…”
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Demonstration of catch bonds between an integrin and its ligand by Kong, Fang, García, Andrés J, Mould, A. Paul, Humphries, Martin J, Zhu, Cheng

“…Binding of integrins to ligands provides anchorage and signals for the cell, making them prime candidates for mechanosensing molecules. How force regulates…”
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Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions by Kong, Fang, Li, Zhenhai, Parks, William M., Dumbauld, David W., García, Andrés J., Mould, A. Paul, Humphries, Martin J., Zhu, Cheng

“…Cells regulate adhesion in response to internally generated and externally applied forces. Integrins connect the extracellular matrix to the cytoskeleton and…”
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Toward a brain-based componential semantic representation by Binder, Jeffrey R., Conant, Lisa L., Humphries, Colin J., Fernandino, Leonardo, Simons, Stephen B., Aguilar, Mario, Desai, Rutvik H.

“…Componential theories of lexical semantics assume that concepts can be represented by sets of features or attributes that are in some sense primitive or basic…”
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Conformational equilibria and intrinsic affinities define integrin activation by Li, Jing, Su, Yang, Xia, Wei, Qin, Yan, Humphries, Martin J, Vestweber, Dietmar, Cabañas, Carlos, Lu, Chafen, Springer, Timothy A

“…We show that the three conformational states of integrin α 5 β 1 have discrete free energies and define activation by measuring intrinsic affinities for ligand…”
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The host dark matter haloes of [O II] emitters at 0.5 < z < 1.5 by Gonzalez-Perez, V, Comparat, J, Norberg, P, Baugh, C M, Contreras, S, Lacey, C, McCullagh, N, Orsi, A, Helly, J, Humphries, J

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Flexible Blade‐Coated Multicolor Polymer Light‐Emitting Diodes for Optoelectronic Sensors by Han, Donggeon, Khan, Yasser, Ting, Jonathan, King, Simon M., Yaacobi‐Gross, Nir, Humphries, Martin J., Newsome, Christopher J., Arias, Ana C.

“…A method to print two materials of different functionality during the same printing step is presented. In printed electronics, devices are built layer by layer…”
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Synergistic control of cell adhesion by integrins and syndecans by Humphries, Martin J, Morgan, Mark R, Bass, Mark D

“…The ability of cells to adhere to each other and to their surrounding extracellular matrices is essential for a multicellular existence. Adhesion provides…”
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Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix by LENNON, Rachel, BYRON, Adam, HUMPHRIES, Jonathan D, RANDLES, Michael J, CARISEY, Alex, MURPHY, Stephanie, KNIGHT, David, BRENCHLEY, Paul E, ZENT, Roy, HUMPHRIES, Martin J

“…The glomerulus contains unique cellular and extracellular matrix (ECM) components, which are required for intact barrier function. Studies of the cellular…”
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Searching for wide-orbit gravitational instability protoplanets with ALMA in the dust continuum by Humphries, J, Hall, C, Haworth, T J, Nayakshin, S

“…ABSTRACT Searches for young gas giant planets at wide separations have so far focused on techniques appropriate for compact (Jupiter-sized) planets. Here, we…”
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Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling by Morgan, Mark R., Hamidi, Hellyeh, Bass, Mark D., Warwood, Stacey, Ballestrem, Christoph, Humphries, Martin J.

“…Precise spatiotemporal coordination of integrin adhesion complex dynamics is essential for efficient cell migration. For cells adherent to fibronectin,…”
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Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking by Linscheid, Nora, Logantha, Sunil Jit R. J., Poulsen, Pi Camilla, Zhang, Shanzhuo, Schrölkamp, Maren, Egerod, Kristoffer Lihme, Thompson, Jonatan James, Kitmitto, Ashraf, Galli, Gina, Humphries, Martin J., Zhang, Henggui, Pers, Tune H., Olsen, Jesper Velgaard, Boyett, Mark, Lundby, Alicia

“…The sinus node is a collection of highly specialised cells constituting the heart’s pacemaker. The molecular underpinnings of its pacemaking abilities are…”
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