Search Results - "Humphries, Brock A."

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer by Humphries, Brock A, Cutter, Alyssa C, Buschhaus, Johanna M, Chen, Yu-Chih, Qyli, Tonela, Palagama, Dilrukshika S W, Eckley, Samantha, Robison, Tanner H, Bevoor, Avinash, Chiang, Benjamin, Haley, Henry R, Sahoo, Saswat, Spinosa, Phillip C, Neale, Dylan B, Boppisetti, Jagadish, Sahoo, Debashis, Ghosh, Pradipta, Lahann, Joerg, Ross, Brian D, Yoon, Eusik, Luker, Kathryn E, Luker, Gary D

“…Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for…”
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Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer by Humphries, Brock A, Buschhaus, Johanna M, Chen, Yu-Chih, Haley, Henry R, Qyli, Tonela, Chiang, Benjamin, Shen, Nathan, Rajendran, Shrila, Cutter, Alyssa, Cheng, Yu-Heng, Chen, Yu-Ting, Cong, Jason, Spinosa, Phillip C, Yoon, Euisik, Luker, Kathryn E, Luker, Gary D

“…Migration and invasion of cancer cells constitute fundamental processes in tumor progression and metastasis. Migratory cancer cells commonly upregulate…”
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MicroRNAs : Novel Players in Cancer Diagnosis and Therapies by Oom, Aaron L., Humphries, Brock A., Yang, Chengfeng

“…First discovered in 1993, microRNAs (miRNAs) have been one of the hottest research areas over the past two decades. Oftentimes, miRNAs levels are found to be…”
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Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4 by Spinosa, Phillip C, Humphries, Brock A, Lewin Mejia, Daniela, Buschhaus, Johanna M, Linderman, Jennifer J, Luker, Gary D, Luker, Kathryn E

“…The chemokine receptor CXCR4 regulates fundamental processes in development, normal physiology, and diseases, including cancer. Small subpopulations of…”
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Root-Localized Phytochrome Chromophore Synthesis Is Required for Photoregulation of Root Elongation and Impacts Root Sensitivity to Jasmonic Acid in Arabidopsis by Costigan, Stephanie E., Warnasooriya, Sankalpi N., Humphries, Brock A., Montgomery, Beronda L.

“…Plants exhibit organ-and tissue-specific light responses. To explore the molecular basis of spatial-specific phytochromeregulated responses, a transgenic…”
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Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through an ROS-dependent mechanism by Humphries, Brock A., Zhang, Anne, Buschhaus, Johanna M., Bevoor, Avinash, Farfel, Alex, Rajendran, Shrila, Cutter, Alyssa C., Luker, Gary D.

“…Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between…”
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Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays by Kinnunen, Patrick C., Humphries, Brock A., Luker, Gary D., Luker, Kathryn E., Linderman, Jennifer J.

“…Single cancer cells within a tumor exhibit variable levels of resistance to drugs, ultimately leading to treatment failures. While tumor heterogeneity is…”
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Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms by Robison, Tanner H., Solipuram, Manisha, Heist, Kevin, Amouzandeh, Ghoncheh, Lee, Winston Y., Humphries, Brock A., Buschhaus, Johanna M., Bevoor, Avinash, Zhang, Anne, Luker, Kathryn E., Pettit, Kristen, Talpaz, Moshe, Malyarenko, Dariya, Chenevert, Thomas L., Ross, Brian D., Luker, Gary D.

“…Histopathology, the standard method to assess BM in hematologic malignancies such as myeloproliferative neoplasms (MPNs), suffers from notable limitations in…”
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MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis by Humphries, Brock A, Wang, Zhishan, Yang, Chengfeng

“…The small Rho GTPases regulate important cellular processes that affect cancer metastasis, such as cell survival and proliferation, actin dynamics, adhesion,…”
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Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel by Hiraki, Harrison L., Matera, Daniel L., Wang, William Y., Prabhu, Eashan S., Zhang, Zane, Midekssa, Firaol, Argento, Anna E., Buschhaus, Johanna M., Humphries, Brock A., Luker, Gary D., Pena-Francesch, Abdon, Baker, Brendon M.

“…The peritumoral stroma is a complex 3D tissue that provides cells with myriad biophysical and biochemical cues. Histologic observations suggest that during…”
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Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow by Buschhaus, Johanna M., Humphries, Brock A., Eckley, Samantha S., Robison, Tanner H., Cutter, Alyssa C., Rajendran, Shrila, Haley, Henry R., Bevoor, Avinash S., Luker, Kathryn E., Luker, Gary D.

“…Estrogen receptor-positive (ER+) breast cancer can recur up to 20 years after initial diagnosis. Delayed recurrences arise from disseminated tumors cells…”
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Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer by Buschhaus, Johanna M., Rajendran, Shrila, Humphries, Brock A., Cutter, Alyssa C., Muñiz, Ayşe J., Ciavattone, Nicholas G., Buschhaus, Alexander M., Cañeque, Tatiana, Nwosu, Zeribe C., Sahoo, Debashis, Bevoor, Avinash S., Shah, Yatrik M., Lyssiotis, Costas A., Ghosh, Pradipta, Wicha, Max S., Rodriguez, Raphaël, Luker, Gary D.

“…Patients with estrogen receptor-positive (ER+) breast cancer, the most common subtype, remain at risk for lethal metastatic disease years after diagnosis…”
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Bone Marrow Mesenchymal Stem Cells Induce Metabolic Plasticity in Estrogen Receptor-Positive Breast Cancer by Buschhaus, Johanna M, Rajendran, Shrila, Chen, Siyi, Wharram, Bryan L, Bevoor, Avinash S, Cutter, Alyssa C, Humphries, Brock A, Robison, Tanner H, Farfel, Alex P, Luker, Gary D

“…Cancer cells reprogram energy metabolism through metabolic plasticity, adapting ATP-generating pathways in response to treatment or microenvironmental changes…”
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Ultrasound‐Induced Mechanical Compaction in Acoustically Responsive Scaffolds Promotes Spatiotemporally Modulated Signaling in Triple Negative Breast Cancer by Humphries, Brock A., Aliabouzar, Mitra, Quesada, Carole, Bevoor, Avinash, Ho, Kenneth K. Y., Farfel, Alex, Buschhaus, Johanna M., Rajendran, Shrila, Fabiilli, Mario L., Luker, Gary D.

“…Cancer cells continually sense and respond to mechanical cues from the extracellular matrix (ECM). Interaction with the ECM can alter intracellular signaling…”
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Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling by Spinosa, Phillip C., Kinnunen, Patrick C., Humphries, Brock A., Luker, Gary D., Luker, Kathryn E., Linderman, Jennifer J.

“…Introduction CXCR4 and epidermal growth factor receptor (EGFR) represent two major families of receptors, G-protein coupled receptors and receptor tyrosine…”
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Aligned Networks of Engineered Fibrillar Fibronectin Guide Cellular Orientation and Motility by Neale, Dylan B., Muñiz, Ayşe J., Jones, Michael S., Kim, Do Hoon, Buschhaus, Johanna M., Humphries, Brock A., Wang, William Y., Baker, Brendon M., Raymond, Jeffery E., Solorio, Luis, Luker, Gary D., Lahann, Joerg

“…The extracellular matrix (ECM) influences biological processes associated with tissue development and disease progression. However, robust cell‐free techniques…”
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Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells by Eckley, Samantha S, Buschhaus, Johanna M, Humphries, Brock A, Robison, Tanner H, Luker, Kathryn E, Luker, Gary D

“…Tumor microenvironments expose cancer cells to heterogeneous, dynamic environments by shifting availability of nutrients, growth factors, and metabolites…”
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Root-Localized Phytochrome Chromophore Synthesis Is Required for Photoregulation of Root Elongation and Impacts Root Sensitivity to Jasmonic Acid in Arabidopsis1[W][OA] by Costigan, Stephanie E, Warnasooriya, Sankalpi N, Humphries, Brock A, Montgomery, Beronda L

“…Plants exhibit organ- and tissue-specific light responses. To explore the molecular basis of spatial-specific phytochrome-regulated responses, a transgenic…”
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Spermatozoon ultrastructure of hangingflies, Bittacus strigosus and Bittacus stigmaterus by Shepardson, Sally P, Humphries, Brock A, Pelkki, Kathleen L, Stanton, David J

“…In the present study, spermatozoon ultrastructure was documented in two species of hangingflies, Bittacus strigosus Hagen (Mecoptera: Bittacidae) and B…”
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Spermatozoon Ultrastructure of Hangingflies, Bittacus strigosus and Bittacus stigmaterus by Shepardson, Sally P., Humphries, Brock A., Pelkki, Kathleen L., Stanton, David J.

“…In the present study, spermatozoon ultrastructure was documented in two species of hangingflies, Bittacus strigosus Hagen (Mecoptera: Bittacidae) and B…”
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