Search Results - "Humphreys, I. R."

IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses by Clement, M., Forbester, J. L., Marsden, M., Sabberwal, P., Sommerville, M. S., Wellington, D., Dimonte, S., Clare, S., Harcourt, K., Yin, Z., Nobre, L., Antrobus, R., Jin, B., Chen, M., Makvandi-Nejad, S., Lindborg, J. A., Strittmatter, S. M., Weekes, M. P., Stanton, R. J., Dong, T., Humphreys, I. R.

“…Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral pathogenesis and exerts poorly understood immunoregulatory…”
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Reply to A scientific basis for anxiety about the emergence of resistant strains of Covid-19 by Humphreys, I R, Godkin, A J

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The potential risks of delaying the second vaccine dose during the SARS-CoV-2 pandemic by Humphreys, I R, Godkin, A J

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Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane by Smith, S E, Busse, D C, Binter, S, Weston, S, Diaz Soria, C, Laksono, B M, Clare, S, Van Nieuwkoop, S, Van den Hoogen, B G, Clement, M, Marsden, M, Humphreys, I R, Marsh, M, de Swart, R L, Wash, R S, Tregoning, J S, Kellam, P

“…The acute antiviral response is mediated by a family of interferon-stimulated genes (ISGs), providing cell-intrinsic immunity. Mutations in genes encoding…”
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Nasal vaccination induces protective immunity without immunopathology by HUSSELL, T., HUMPHREYS, I. R.

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The potential risks of delaying the second vaccine dose during the SARS-CoV-2 pandemic by Humphreys, I R, Godkin, A J

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SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies by Fielding, Ceri Alan, Sabberwal, Pragati, Williamson, James C, Greenwood, Edward J D, Crozier, Thomas W M, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D, Price, David A, Morgan, Paul B, Ladell, Kristin, Eberl, Matthias, Humphreys, Ian R, Merrick, Blair, Doores, Katie, Wilson, Sam J, Lehner, Paul J, Wang, Eddie C Y, Stanton, Richard J

“…The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to…”
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Characterization in mice of the immunological properties of five allergenic acid anhydrides by Dearman, Rebecca J., Warbrick, E. Vicky, Humphreys, Ian R., Kimber, Ian

“…Occupational exposure to certain acid anhydrides, including trimellitic anhydride (TMA), maleic anhydride (MA), phthalic anhydride (PA), hexahydrophthalic…”
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Evolutionarily Divergent Herpesviruses Modulate T Cell Activation by Targeting the Herpesvirus Entry Mediator Cosignaling Pathway by Cheung, Timothy C., Humphreys, Ian R., Potter, Karen G., Norris, Paula S., Shumway, Heather M., Tran, Bonnie R., Patterson, Ginelle, Jean-Jacques, Rochelle, Yoon, Miri, Spear, Patricia G., Murphy, Kenneth M., Lurain, Nell S., Benedict, Chris A., Ware, Carl F.

“…The herpesvirus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by…”
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A critical role for OX40 in T cell-mediated immunopathology during lung viral infection by Humphreys, Ian R, Walzl, Gerhard, Edwards, Lorna, Rae, Aaron, Hill, Sue, Hussell, Tracy

“…Respiratory infections are the third leading cause of death worldwide. Illness is caused by pathogen replication and disruption of airway homeostasis by…”
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Herpesvirus exploitation of host immune inhibitory pathways by Stack, Gabrielle, Stacey, Maria A, Humphreys, Ian R

“…Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of…”
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Innate Imprinting by the Modified Heat-Labile Toxin of Escherichia coli (LTK63) Provides Generic Protection against Lung Infectious Disease by Williams, Andrew Evan, Edwards, Lorna, Humphreys, Ian Robert, Snelgrove, Robert, Rae, Aaron, Rappuoli, Rino, Hussell, Tracy

“…In a healthy individual, the lung contains few lymphoid cells. However, amplified immune responses, as exemplified during lung infection, can cause extensive…”
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The stress‐responsive chaperone α‐crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis by Stewart, Graham R., Newton, Sandra M., Wilkinson, Katalin A., Humphreys, Ian R., Murphy, Helen N., Robertson, Brian D., Wilkinson, Robert J., Young, Douglas B.

“…Summary Mycobacterium tuberculosis has two members of the α‐crystallin (Acr) family of molecular chaperones. Expression of Acr1 is induced by exposure to…”
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TGF-β prevents eosinophilic lung disease but impairs pathogen clearance by Williams, Andrew Evan, Humphreys, Ian Robert, Cornere, Megan, Edwards, Lorna, Rae, Aaron, Hussell, Tracy

“…Respiratory infections are the third leading cause of death worldwide. Complications arise directly as a consequence of pathogen replication or indirectly due…”
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OX40 Ligation on Activated T Cells Enhances the Control of Cryptococcus neoformans and Reduces Pulmonary Eosinophilia by Humphreys, Ian R, Edwards, Lorna, Walzl, Gerhard, Rae, Aaron J, Dougan, Gordon, Hill, Sue, Hussell, Tracy

“…Pulmonary eosinophilia induced in C57BL/6 mice after Cryptococcus neoformans infection is driven by CD4(+) Th2 cells. The immunological mechanisms that protect…”
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Co-stimulation: novel methods for preventing viral-induced lung inflammation by Hussell, Tracy, Snelgrove, Robert, Humphreys, Ian R., Williams, Andrew E.

“…Respiratory infections cause significant morbidity and mortality worldwide. Although an immune response is required to eliminate respiratory pathogens, if…”
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Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines by Hale, Christine, Humphreys, Ian R, Hussell, Tracy, Bowe, Frances, Clare, Simon, Pickard, Derek, Preston, Andrew, Del Giudice, Giuseppe, Dougan, Gordon

“…Groups of neonatal mice were immunised with different mucosal vaccines based on acellular (Pertactin antigen) or whole cell (inactivated Bordetella pertussis…”
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Prior Exposure to Live Mycobacterium bovis BCG Decreases Cryptococcus neoformans-Induced Lung Eosinophilia in a Gamma Interferon-Dependent Manner by WALZL, Gerhard, HUMPHREYS, Ian R, MARSHALL, Ben G, EDWARDS, Lorna, OPENSHAW, Peter J. M, SHAW, Rory J, HUSSELL, Tracy

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides by Dearman, Rebecca J., Filby, Andrew, Humphreys, Ian R., Kimber, Ian

“…There is some debate regarding whether occupational asthma induced by respiratory sensitizing acid anhydrides is mediated by the induction of T helper (Th)…”
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Annotations of selected papers by foreign scientists by Auerbach, T., Chernick, J., Julien, J., Lellouche, G., Zinn, W., Hummel, H. H., Cohn, C. E., Fischer, G. J., Kate, W. Y., Martens, F. H., Meneghettl, D., Toppel, B. I., Blomberg, P., Hellstr, E., Korner, S., Brlmberg, S., Dalstrom, I., Simon, Albert, Post, R. F., Damm, C. C., Howard, J. C., Wharton, C. B., Spitzer, Lyman, Colmer, F. C. W., Gallic, R. R., Gott, H. H., McNelly, M. J., Shoults, D. R., Levy, S., Voorhees, B. G., Aline, P. G., Cohen, K. P., Humphreys, I. R., Glbrat, R., Rtcard, J., Balke, S., Wivstad, I., Mileikowsky, C., Howells, G. R., Hughes, T. G., Mackey, D. R., Saddington, K., Huber, A. P., Dykstra, J., Thompson, B. H., Lewis, W. H., Flanary, R., Brooksbank, R. E., Leuze, R. E., Baybarz, R. D., Waldron, M. B., Garston, J., Lee, J. A., Mardon, P. G., Marples, J. A. C., Poole, D. M., Wtlllamson, G. K., Videm, K., Hayward, B. R., Hotley, C. E., Mulford, R. N. R., Huber, E. J., Head, E. L., Borklund, K. V., Chiswik, H. H., Oosthuizen, S. A., Pyne-Mercler, W. G., Fichardt, T., Savage, D.

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