Search Results - "Humphreys, Gavin J."

Diabetic foot infection: A critical complication by Hurlow, Jennifer J, Humphreys, Gavin J, Bowling, Frank L, McBain, Andrew J

“…The number of people in the world with diabetes has nearly quadrupled in the past 40 years. Current data show that 25% of these diabetics will develop a foot…”
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Exposure to a Manuka Honey Wound Gel Is Associated With Changes in Bacterial Virulence and Antimicrobial Susceptibility by Mokhtar, Jawahir A., McBain, Andrew J., Ledder, Ruth G., Binsuwaidan, Reem, Rimmer, Victoria, Humphreys, Gavin J.

“…The use of manuka honey for the topical treatment of wounds has increased worldwide owing to its broad spectrum of activity towards bacteria in both planktonic…”
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Investigating oral microbiome dynamics in chronic kidney disease and post-transplantation in continuous culture by Campbell, Paul M, Willmott, Thomas, Summers, Angela, Knight, Christopher G, Humphreys, Gavin J, Konkel, Joanne E, Augustine, Titus, McBain, Andrew J

“…The oral microbiome is influenced by environmental factors in chronic kidney disease and following kidney transplantation affecting microbial composition,…”
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Does the Microbiome Affect the Outcome of Renal Transplantation? by Campbell, Paul M, Humphreys, Gavin J, Summers, Angela M, Konkel, Joanne E, Knight, Christopher G, Augustine, Titus, McBain, Andrew J

“…The role of the human microbiome in health and disease is becoming increasingly apparent. Emerging evidence suggests that the microbiome is affected by solid…”
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Does the Oral Microbiome Play a Role in Hypertensive Pregnancies? by Willmott, Thomas, McBain, Andrew J, Humphreys, Gavin J, Myers, Jenny, Cottrell, Elizabeth

“…Chronic hypertension during gestation is associated with an increased risk of adverse pregnancy outcomes including pre-eclampsia, fetal growth restriction and…”
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Visible label-free detection of bacterial DNA using flocculation of sterically stabilised cationic latexes by Trinh, Elisabeth, Thompson, Kate L, Wen, Shang-Pin, Humphreys, Gavin J, Price, Bianca L, Fielding, Lee A

“…The current gold standard diagnostic for bacterial infections is the use of culture, which can be time consuming and can take up to five days for results to be…”
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Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study by Humphreys, Gavin J., Waqar, Mueez, McBain, Andrew J., Gnanalingham, Kanna K.

“…Purpose There is a high incidence of abnormal sphenoid sinus changes in patients with pituitary apoplexy (PA). Their pathophysiology is currently unexplored…”
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Transitory Shifts in Skin Microbiota Composition and Reductions in Bacterial Load and Psoriasin following Ethanol Perturbation by Saville, Charis R., Metris, Aline, Humphreys, Gavin J., O’Neill, Catherine, Barrett, Paul, Fernandez-Piquer, Judith, McBain, Andrew J.

“…Personal care and hygiene regimens may substantially alter the composition of the skin microbiota through direct and indirect mechanisms. An understanding of…”
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Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride by Forbes, Sarah, Morgan, Nicola, Humphreys, Gavin J, Amézquita, Alejandro, Mistry, Hitesh, McBain, Andrew J

“…Assessing the risk of resistance associated with biocide exposure commonly involves exposing microorganisms to biocides at concentrations close to the MIC…”
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Variable effects of exposure to ionic silver in wound-associated bacterial pathogens by Binsuwaidan, Reem, Almuzaini, Osama, Mercer, Steven, Doherty, Christopher, Mokhtar, Jawahir, McBain, Andrew J, Ledder, Ruth, Humphreys, Gavin J

“…Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic…”
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Investigating the association between nitrate dosing and nitrite generation by the human oral microbiota in continuous culture by Willmott, Thomas, Serrage, Hannah J, Cottrell, Elizabeth C, Humphreys, Gavin J, Myers, Jenny, Campbell, Paul M, McBain, Andrew J

“…The generation of nitrite by the oral microbiota is believed to contribute to healthy cardiovascular function, with oral nitrate reduction to nitrite…”
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Assessing the risk of resistance to cationic biocides incorporating realism-based and biophysical approaches by Fox, Laura J, Kelly, Paul P, Humphreys, Gavin J, Waigh, Thomas A, Lu, Jian R, McBain, Andrew J

“…The control of microorganisms is a key objective in disease prevention and in medical, industrial, domestic, and food-production environments. Whilst the…”
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Distinct microbiome profiles in convergent wisdom tooth impactions by Campbell, Paul M, Toedtling, Verena, Humphreys, Gavin J, Knight, Christopher G, Devlin, Hugh, McBain, Andrew J

“…Long-term retention of impacted third molars (wisdom teeth) is associated with plaque stagnation and the development of caries on the adjacent surface of the…”
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Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation by Willmott, Thomas, Ormesher, Laura, McBain, Andrew J., Humphreys, Gavin J., Myers, Jenny E., Singh, Gurdeep, Lundberg, Jon O., Weitzberg, Eddie, Nihlen, Carina, Cottrell, Elizabeth C.

“…BACKGROUND: The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether…”
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Biofilms and Microbiome Profiles in Chronic Wounds: Links to Antibiotic Use and Wound Severity in a Sri Lankan Cohort by Dilhari, Ayomi, Campbell, Paul M, Munasinghe, Anuradha, Brown, Hannah, Kaluarachchi, Thilini D J, Gunasekara, Chinthika, Pathirage, Sujatha, Fernando, Neluka, Weerasekara, Deepaka, Humphreys, Gavin J, McBain, Andrew J, Weerasekera, Manjula

“…We have characterized the microbiome of infected chronic diabetic wounds (CDWs), exploring associations with antibiotic use and wound severity in a Sri Lankan…”
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Fatty Acid Supplementation Reverses the Small Colony Variant Phenotype in Triclosan-Adapted Staphylococcus aureus: Genetic, Proteomic and Phenotypic Analyses by Bazaid, Abdulrahman S., Forbes, Sarah, Humphreys, Gavin J., Ledder, Ruth G., O’Cualain, Ronan, McBain, Andrew J.

“…Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study,…”
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Transient and sustained bacterial adaptation following repeated sublethal exposure to microbicides and a novel human antimicrobial peptide by Forbes, Sarah, Dobson, Curtis B, Humphreys, Gavin J, McBain, Andrew J

“…Microbicides (biocides) play an important role in the prevention and treatment of infections. While there is currently little evidence for in-use treatment…”
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Effects of Formulation on Microbicide Potency and Mitigation of the Development of Bacterial Insusceptibility by Cowley, Nicola L, Forbes, Sarah, Amézquita, Alejandro, McClure, Peter, Humphreys, Gavin J, McBain, Andrew J

“…Risk assessments of the potential for microbicides to select for reduced bacterial susceptibility have been based largely on data generated through the…”
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Low incidence of coaggregation amongst bacteria isolated from the upper respiratory tract in health and disease by Humphreys, Gavin J, Kumar, Nirmal, McBain, Andrew J

“…The nasal cavity harbours a commensal microbiota that reportedly provides colonization resistance against respiratory pathogens. Following the onset of chronic…”
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Bacteriological effects of dentifrices with and without active ingredients of natural origin by Ledder, Ruth G, Latimer, Joe, Humphreys, Gavin J, Sreenivasan, Prem K, McBain, Andrew J

“…Compounds of natural origin are increasingly used as adjuncts to oral hygiene. We have adopted four distinct approaches to assess the antibacterial activity of…”
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