Search Results - "Humphrey, S. J"

Phase I Clinical Trial Design in Cancer Drug Development by EISENHAUER, E. A, O'DWYER, P. J, CHRISTIAN, M, HUMPHREY, J. S

“…The past decade has seen the publication of a number of new proposals for the design of phase I trials of anticancer agents. The purpose of these proposals has…”
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Localization of TGN38 to the Trans-Golgi Network: Involvement of a Cytoplasmic Tyrosine-Containing Sequence by Humphrey, Jeffrey S., Peters, Peter J., Yuan, Lydia C., Bonifacino, Juan S.

“…Protein localization to the TGN was investigated by examining the subcellular distribution of chimeric proteins in which the cytoplasmic and/or transmembrane…”
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Decision-making Under Risk among Small Farmers in East Uganda by Humphrey, Steven J., Verschoor, Arjan

“…We report an experimental test of individual decision-making behaviour under risk conducted in rural east Uganda. The test employs an incentive compatible…”
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Nuclear / Cytoplasmic Localization of the Von Hippel-Lindau Tumor Suppressor Gene Product is Determined by Cell Density by Lee, Stephen, David Y. T. Chen, Humphrey, Jeffrey S., Gnarra, James R., Linehan, W. Marston, Klausner, Richard D.

“…The product of the von Hippel-Lindau (VHL) tumor suppressor gene, the gene inactivated in VHL disease and in sporadic clear-cell renal carcinomas, has recently…”
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Pharmacokinetics of a degradable drug delivery system in bone by Humphrey, J S, Mehta, S, Seaber, A V, Vail, T P

“…Local delivery of antibiotics via a degradable carrier has the potential for high local antibiotic levels and avoids systemic toxicity. Intravenous access,…”
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Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization by PACK, S. D, ZBAR, B, STOLLE, C, GLENN, G, LIOTTA, L. A, LERMAN, M. I, KLAUSNER, R. D, LINEHAN, W. M, ZHENGPING ZHUANG, PAK, E, AULT, D. O, HUMPHREY, J. S, PHAM, T, HURLEY, K, WEIL, R. J, PARK, W.-S, KUZMIN, I

“…von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited cancer syndrome predisposing to a variety of tumor types that include retinal…”
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Characterization of the VHL Tumor Suppressor Gene Product: Localization, Complex Formation, and the Effect of Natural Inactivating Mutations by Duan, D R, Humphrey, J S, Chen, D Y, Weng, Y, Sukegawa, J, Lee, S, Gnarra, J R, Linehan, W M, Klausner, R D

“…The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal carcinoma. The homologous rat…”
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Gentamicin distribution from a collagen carrier by Mehta, S, Humphrey, J S, Schenkman, D I, Seaber, A V, Vail, T P

“…Local delivery of antibiotics by a degradable carrier has the potential for high local antibiotic levels and avoids systemic toxicity. Intravenous access,…”
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4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers by Meisheri, K D, Humphrey, S J, Khan, S A, Cipkus-Dubray, L A, Smith, M P, Jones, A W

“…This study describes the in vitro and in vivo characteristics of a guanidine 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl-hydroc hloride (U-37883A),…”
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Synchronous monitoring of vulture movements with satellite telemetry and avian radar by Beason, R.C, Humphrey, J.S, Myers, N.E, Avery, M.L

“…Radar and satellite global positioning system-platform transmitter terminal (GPS-PTT) transmitters provide complementary information on the movements and…”
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Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats by Clark, M A, Humphrey, S J, Smith, M P, Ludens, J H

“…Small-conductance, ATP-sensitive K(+)-channels (KATP) localized in apical membranes of both thick ascending limb of the loop of Henle and cortical collecting…”
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Feeding deterrence of anthraquinone, anthracene, and anthrone to rice-eating birds by Avery, M.L. (USDA/APHIS/National Wildlife Research Center, Gainesville, FL.), Humphrey, J.S, Decker, D.G

“…Safe, effective bird repellents are needed as seed treatments and for many other agricultural uses. Quinones are distributed widely in nature and many have…”
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Consumption of fipronil-treated rice seed does not affect captive blackbirds by Avery, Michael L., Primus, Thomas M., Mihaich, Ellen M., Decker, David G., Humphrey, John S.

“…Fipronil is an insecticide developed for use on rice seed and other crops. In a series of cage and pen trials, we evaluated the responses to dyed,…”
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The independent effects of left ventricular ejection fraction on short‐term outcomes and resource utilization following hospitalization for heart failure by Harjai, Kishore J., Nunez, Eduardo, Turgut, Tansel, Shah, Mehul P., Stewart Humphrey, J., Newman, Jeff, Cheirif, Jorge, Smart, Frank W., Ventura, Hector O.

“…While depressed left ventricular ejection fraction is clearly associated with poor long-term outcome in heart failure (HF), the effect of ejection fraction on…”
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Parasite Antigen-Induced IFNγ and IL-4 Production by Cells from Pathopermissive and Pathoresistant Strains of Mice Infected with Trypanosoma cruzi by Humphrey, J. S., McCormick, T. S., Rowland, E. C.

“…The cardiac pathology associated with infection by Trypanosoma cruzi in mice has been suggested to be partially dependent upon cytokine responses. The…”
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TGN38 recycles basolaterally in polarized Madin-Darby canine kidney cells by Rajasekaran, A K, Humphrey, J S, Wagner, M, Miesenböck, G, Le Bivic, A, Bonifacino, J S, Rodriguez-Boulan, E

“…Sorting of newly synthesized plasma membrane proteins to the apical or basolateral surface domains of polarized cells is currently thought to take place within…”
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Cardiovascular and pharmacokinetic interactions between nicorandil and adjunctive propranolol, atenolol or diltiazem in conscious dogs by HUMPHREY, S. J

“…In support of clinical antianginal studies, the vasodilator nicorandil (NIC) was combined with the beta-adrenergic receptor antagonists propranolol (PRO) and…”
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Methyl anthranilate as a rice seed treatment to deter birds by Avery, Michael L., Decker, David G., Humphrey, John S., Aronov, Evgeny, Linscombe, Steven D., Way, M. O.

“…Red-winged blackbirds (Agelaius phoeniceus) and related species cause millions of dollars of damage annually to sprouting rice in Louisiana and Texas. Seed…”
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Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene by Stolle, Catherine, Glenn, Gladys, Zbar, Berton, Humphrey, Jeffrey S., Choyke, Peter, Walther, McClellan, Pack, Svetlanna, Hurley, Kathy, Andrey, Carolyn, Klausner, Richard, Linehan, W. Marston

“…von Hippel‐Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear,…”
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Cardiovascular interactions characterizing the vasodilator components of nicorandil in conscious dogs by Humphrey, S J, Schwende, F J

“…We conducted cardiovascular interaction studies in conscious dogs to characterize the cyclic GMP and KATP channel opener (PCO)-dependent peripheral vasodilator…”
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