Search Results - "Humphrey, Melissa"
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Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
Published in Nature communications (02-07-2019)“…PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRCA-intact tumors, including glioblastoma (GBM). We show that MYC or MYCN…”
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Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
Published in Journal of visualized experiments (13-05-2021)“…Oncolytic viruses (OVs), such as the oncolytic herpes simplex virus (oHSV), are a rapidly growing treatment strategy in the field of cancer immunotherapy. OVs,…”
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A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)
Published in Nature communications (28-06-2019)“…Cell state-specific promoters constitute essential tools for basic research and biotechnology because they activate gene expression only under certain…”
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Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells
Published in Molecular therapy. Oncolytics (28-06-2019)“…Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate…”
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Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients
Published in International journal of antimicrobial agents (01-01-2013)“…Abstract The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged…”
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Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit
Published in Journal of clinical pharmacology (01-03-2014)“…The study objective was to evaluate meropenem pharmacokinetics and pharmacodynamics in morbid obesity. Nine patients hospitalized in an intensive care unit…”
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Steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients
Published in International journal of antimicrobial agents (01-01-2011)“…Abstract The objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in…”
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Effects of Omeprazole on Vitamin and Mineral Absorption and Metabolism
Published in The Journal of pharmacy technology (01-11-2012)“…Objective: To examine the literature surrounding the effects of omeprazole on oral iron absorption and discuss the long-term use of omeprazole and its effect…”
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Reducing Class-Scheduling Conflicts Using Linear Programming
Published in Journal of professional issues in engineering education and practice (01-10-2017)“…AbstractThe scheduling of college courses within a given semester plays a crucial role in a student’s daily life, educational and professional pursuits, and…”
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