Search Results - "Humphrey, J"

Numerical knockouts-In silico assessment of factors predisposing to thoracic aortic aneurysms by Latorre, M, Humphrey, J D

“…Myriad risk factors-including uncontrolled hypertension, aging, and diverse genetic mutations-contribute to the development and enlargement of thoracic aortic…”
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Forty years of Helicobacter pylori infection and changes in findings at esophagogastroduodenoscopy by O'Connor, Humphrey J.

“…Abstract Background It is 40 years since the discovery of Helicobacter pylori infection. Over that time major changes have occurred in…”
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Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology by Robles, Maria S., Humphrey, Sean J., Mann, Matthias

“…Circadian clocks are self-sustainable endogenous oscillators, present in virtually every cell, driving daily cycles of metabolism and physiology. The molecular…”
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Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation by Humphrey, Sean J, James, David E, Mann, Matthias

“…Metabolism research is undergoing a renaissance because many diseases are increasingly recognized as being characterized by perturbations in intracellular…”
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Central artery stiffness and thoracic aortopathy by Humphrey, J D, Tellides, G

“…Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for significant morbidity and mortality. Uncontrolled hypertension and aging…”
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High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics by Humphrey, Sean J, Azimifar, S Babak, Mann, Matthias

“…Phosphoproteomes are rapidly measured in parallel to track the dynamics of insulin signaling in the liver. Mass spectrometry has enabled the study of cellular…”
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Constrained Mixture Models of Soft Tissue Growth and Remodeling – Twenty Years After by Humphrey, J. D.

“…Soft biological tissues compromise diverse cell types and extracellular matrix constituents, each of which can possess individual natural configurations,…”
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Vascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels by Humphrey, J. D.

“…Blood vessels exhibit a remarkable ability to adapt throughout life that depends upon genetic programming and well-orchestrated biochemical processes. Findings…”
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A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation by Yang, Guang, Murashige, Danielle S., Humphrey, Sean J., James, David E.

“…The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates;…”
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Dark Matter Detection Using Helium Evaporation and Field Ionization by Maris, Humphrey J, Seidel, George M, Stein, Derek

“…We describe a method for dark matter detection based on the evaporation of helium atoms from a cold surface and their subsequent detection using field…”
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Illuminating the dark phosphoproteome by Needham, Elise J, Parker, Benjamin L, Burykin, Timur, James, David E, Humphrey, Sean J

“…Protein phosphorylation is a major regulator of protein function and biological outcomes. This was first recognized through functional biochemical experiments,…”
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Note on the history effect in fluid mechanics by Maris, Humphrey J.

“…A freshman mechanics course often includes a theoretical discussion or demonstration of the motion of solid particles through fluids. The effect of viscosity…”
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Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates by Hoffman, Nolan J., Parker, Benjamin L., Chaudhuri, Rima, Fisher-Wellman, Kelsey H., Kleinert, Maximilian, Humphrey, Sean J., Yang, Pengyi, Holliday, Mira, Trefely, Sophie, Fazakerley, Daniel J., Stöckli, Jacqueline, Burchfield, James G., Jensen, Thomas E., Jothi, Raja, Kiens, Bente, Wojtaszewski, Jørgen F.P., Richter, Erik A., James, David E.

“…Exercise is essential in regulating energy metabolism and whole-body insulin sensitivity. To explore the exercise signaling network, we undertook a global…”
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Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β by Humphrey, J D

“…Four distinguishing histopathological characteristics of thoracic aortic aneurysms and dissections (TAADs) are the fragmentation or degradation of elastic…”
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Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models by Ferruzzi, J., Bersi, M. R., Humphrey, J. D.

“…The stiffness and structural integrity of the arterial wall depends primarily on the organization of the extracellular matrix and the cells that fashion and…”
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Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets by Sacco, Francesca, Seelig, Anett, Humphrey, Sean J., Krahmer, Natalie, Volta, Francesco, Reggio, Alessio, Marchetti, Piero, Gerdes, Jantje, Mann, Matthias

“…Progressive decline of pancreatic beta cell function is central to the pathogenesis of type 2 diabetes. Protein phosphorylation regulates glucose-stimulated…”
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Growth and remodeling of load-bearing biological soft tissues by Cyron, C. J., Humphrey, J. D.

“…The past two decades reveal a growing role of continuum biomechanics in understanding homeostasis, adaptation, and disease progression in soft tissues. In this…”
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New computational approach to shunt design in congenital heart palliation by Ban, E., Humphrey, J.D.

“…Shunts are commonly used to redirect blood to pulmonary arteries in procedures that palliate congenital cardiovascular defects. Previous clinical studies and…”
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Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms by Humphrey, J.D, Holzapfel, G.A

“…Abstract Biomechanical factors play fundamental roles in the natural history of abdominal aortic aneurysms (AAAs) and their responses to treatment. Advances…”
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Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension by Bersi, M. R., Khosravi, R., Wujciak, A. J., Harrison, D. G., Humphrey, J. D.

“…The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads…”
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