Search Results - "Humora, Michael J."

Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632 by Xu, Zhongmin, Singh, Janak, Schwinden, Mark D, Zheng, Bin, Kissick, Thomas P, Patel, Bharat, Humora, Michael J, Quiroz, Fernando, Dong, Lin, Hsieh, Dau-Ming, Heikes, James E, Pudipeddi, Madhusudhan, Lindrud, Mark D, Srivastava, Sushil K, Kronenthal, David R, Mueller, Richard H

“…Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632…”
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Removal of Palladium from Organic Reaction Mixtures by Trimercaptotriazine by Rosso, Victor W, Lust, David A, Bernot, Peter J, Grosso, John A, Modi, Sandeep P, Rusowicz, Andrew, Sedergran, Thomas C, Simpson, James H, Srivastava, Sushil K, Humora, Michael J, Anderson, Neal G

“…In an effort to remove residual palladium from a drug candidate prepared by palladium-catalyzed indolization, many treatments were examined. The most effective…”
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Understanding and Control of Dimethyl Sulfate in a Manufacturing Process: Kinetic Modeling of a Fischer Esterification Catalyzed by H2SO4 by Guzowski, John P, Delaney, Edward J, Humora, Michael J, Irdam, Erwin, Kiesman, William F, Kwok, Albert, Moran, Amy D

“…The formation and fate of monomethyl sulfate (MMS) and dimethyl sulfate (DMS) were studied by proton NMR for a sulfuric acid catalyzed esterification reaction…”
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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator by Peng, Hairuo, Talreja, Tina, Xin, Zhili, Cuervo, J. Hernan, Kumaravel, Gnanasambandam, Humora, Michael J, Xu, Lin, Rohde, Ellen, Gan, Lawrence, Jung, Mi-young, Shackett, Melanie N, Chollate, Sowmya, Dunah, Anthone W, Snodgrass-belt, Pamela A, Arnold, H. Moore, Taveras, Arthur G, Rhodes, Kenneth J, Scannevin, Robert H

“…We have investigated a novel series of acid-derived γ-secretase modulators as a potential treatment of Alzheimer's disease. Optimization based on cellular…”
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Development of an Early Phase Process for a Potent Oligodendrocyte Precursor Cell Differentiator by Walker, Donald G., Ferguson, Steven, Humora, Michael J., Irdam, Erwin, Kiesman, William F., Kwok, Daw-Iong Albert, Liang, Wenli, Opalka, Suzanne M.

“…Herein are described improvements in a discovery synthesis to enable a rapid scale up of 1 to support early phase clinical trials and formulation development…”
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A Practical Synthesis of an Anti-Methicillin Resistant Staphylococcus aureus Cephalosporin BMS-247243 by Singh, Janak, Kim, Oak K, Kissick, Thomas P, Natalie, Kenneth J, Zhang, Bo, Crispino, Gerard A, Springer, Dane M, Wichtowski, John A, Zhang, Yunhui, Goodrich, Jason, Ueda, Yasutsugu, Luh, Bing Y, Burke, Brian D, Brown, Matthew, Dutka, Anthony P, Zheng, Bin, Hsieh, Dau-Ming, Humora, Michael J, North, Jeffrey T, Pullockaran, Anne J, Livshits, Juliya, Swaminathan, Shankar, Gao, Zhinong, Schierling, Peter, Ermann, Peter, Perrone, Robert K, Lai, Mei C, Gougoutas, Jack Z, DiMarco, John D, Bronson, Joanne J, Heikes, James E, Grosso, John A, Kronenthal, David R, Denzel, Theodor W, Mueller, Richard H

“…A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem…”
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Diastereoselective Reaction of a Grignard Reagent with Chiral Imides:  A Practical Preparation of a Key Intermediate in the Synthesis of Ifetroban Sodium by Mueller, Richard H, Wang, Shaopeng, Pansegrau, Paul D, Jannotti, Joy Q, Poss, Michael A, Thottathil, John K, Singh, Janak, Humora, Michael J, Kissick, Thomas P, Boyhan, Brenda

“…A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a…”
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Understanding and Control of Dimethyl Sulfate in a Manufacturing Process: Kinetic Modeling of a Fischer Esterification Catalyzed by H 2 SO 4 by Guzowski, John P., Delaney, Edward J., Humora, Michael J., Irdam, Erwin, Kiesman, William F., Kwok, Albert, Moran, Amy D.

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Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the KATP opener BMS-180448 by Chen, Bang-Chi, Quinlan, Sandra L, Reid, J.Gregory, Jass, Paul A, Robinson, Tonya P, Early, William A, Delaney, Edward J, Humora, Michael J, Madding, Gary D, Venit, John J, Winter, William J

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Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the K ATP opener BMS-180448 by Chen, Bang-Chi, Quinlan, Sandra L, Reid, J.Gregory, Jass, Paul A, Robinson, Tonya P, Early, William A, Delaney, Edward J, Humora, Michael J, Madding, Gary D, Venit, John J, Winter, William J

“…BMS-180448, (3S,4R)- 2, was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with…”
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