Search Results - "Hummel, Selina"
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Tau deposition patterns are associated with functional connectivity in primary tauopathies
Published in Nature communications (15-03-2022)“…Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau…”
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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Published in Molecular neurodegeneration (11-06-2022)“…Genetic mutations underlying familial Alzheimer's disease (AD) were identified decades ago, but the field is still in search of transformative therapies for…”
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Real-Time Volumetric Ultrasound Research Platform with 1024 Parallel Transmit and Receive Channels
Published in Applied sciences (01-07-2021)“…Volumetric ultrasound imaging is of great importance in many medical fields, especially in cardiology, but also in therapy monitoring applications. For…”
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Depletion and activation of microglia impact metabolic connectivity of the mouse brain
Published in Journal of neuroinflammation (24-02-2023)“…We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine…”
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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Published in Nature neuroscience (01-03-2023)“…Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor…”
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Distinct molecular profiles of skull bone marrow in health and neurological disorders
Published in Cell (17-08-2023)“…The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human…”
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Integrated 1024 channel ultrasound beamformer for ultrasound research
Published in 2020 IEEE International Ultrasonics Symposium (IUS) (07-09-2020)“…Volumetric ultrasound imaging is of most importance not only for real time cardiac imaging and quantization of flow but also for niche applications like motion…”
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