Search Results - "Hummel, Oliver"

Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo by Abranches, Elsa, Silva, Margarida, Pradier, Laurent, Schulz, Herbert, Hummel, Oliver, Henrique, Domingos, Bekman, Evguenia

“…The in vitro generation of neurons from embryonic stem (ES) cells is a promising approach to produce cells suitable for neural tissue repair and cell-based…”
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Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells by Aksoy, Irène, Giudice, Vincent, Delahaye, Edwige, Wianny, Florence, Aubry, Maxime, Mure, Magali, Chen, Jiaxuan, Jauch, Ralf, Bogu, Gireesh K., Nolden, Tobias, Himmelbauer, Heinz, Xavier Doss, Michael, Sachinidis, Agapios, Schulz, Herbert, Hummel, Oliver, Martinelli, Paola, Hübner, Norbert, Stanton, Lawrence W., Real, Francisco X., Bourillot, Pierre-Yves, Savatier, Pierre

“…Krüppel-like factors (Klf) 4 and 5 are two closely related members of the Klf family, known to play key roles in cell cycle regulation, somatic cell…”
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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion by Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan

“…Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the…”
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Natural variation of histone modification and its impact on gene expression in the rat genome by Rintisch, Carola, Heinig, Matthias, Bauerfeind, Anja, Schafer, Sebastian, Mieth, Christin, Patone, Giannino, Hummel, Oliver, Chen, Wei, Cook, Stuart, Cuppen, Edwin, Colomé-Tatché, Maria, Johannes, Frank, Jansen, Ritsert C, Neil, Helen, Werner, Michel, Pravenec, Michal, Vingron, Martin, Hubner, Norbert

“…Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of…”
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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease by Pravenec, Michal, Aitman, Timothy J, Hubner, Norbert, Wallace, Caroline A, Zimdahl, Heike, Petretto, Enrico, Schulz, Herbert, Maciver, Fiona, Mueller, Michael, Hummel, Oliver, Monti, Jan, Zidek, Vaclav, Musilova, Alena, Kren, Vladimir, Causton, Helen, Game, Laurence, Born, Gabriele, Schmidt, Sabine, Müller, Anita, Cook, Stuart A, Kurtz, Theodore W, Whittaker, John

“…Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this…”
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Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis by Karantzali, Efthimia, Schulz, Herbert, Hummel, Oliver, Hubner, Norbert, Hatzopoulos, Ak, Kretsovali, Androniki

“…Epigenetic mechanisms regulate gene expression patterns affecting cell function and differentiation. In this report, we examine the role of histone acetylation…”
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Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism by Kim, Hyung-Goo, Rosenfeld, Jill A, Scott, Daryl A, Bénédicte, Gerard, Labonne, Jonathan D, Brown, Jason, McGuire, Marianne, Mahida, Sonal, Naidu, Sakkubai, Gutierrez, Jacqueline, Lesca, Gaetan, des Portes, Vincent, Bruel, Ange-Line, Sorlin, Arthur, Xia, Fan, Capri, Yline, Muller, Eric, McKnight, Dianalee, Torti, Erin, Rüschendorf, Franz, Hummel, Oliver, Islam, Zeyaul, Kolatkar, Prasanna R, Layman, Lawrence C, Ryu, Duchwan, Kong, Il-Keun, Madan-Khetarpal, Suneeta, Kim, Cheol-Hee

“…has been associated with intellectual disability and craniofacial anomalies based on its deletion in the Potocki-Shaffer syndrome region at 11p11.2 and its…”
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Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease by Rubattu, Speranza, Di Castro, Sara, Schulz, Herbert, Geurts, Aron M., Cotugno, Maria, Bianchi, Franca, Maatz, Henrike, Hummel, Oliver, Falak, Samreen, Stanzione, Rosita, Marchitti, Simona, Scarpino, Stefania, Giusti, Betti, Kura, Ada, Gensini, Gian Franco, Peyvandi, Flora, Mannucci, Pier Mannuccio, Rasura, Maurizia, Sciarretta, Sebastiano, Dwinell, Melinda R., Hubner, Norbert, Volpe, Massimo

“…Background The genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of…”
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Decoding fMRI alcohol cue reactivity and its association with drinking behaviour by Tan, Haoye, Gerchen, Martin Fungisai, Bach, Patrick, Lee, Alycia M, Hummel, Oliver, Sommer, Wolfgang, Kirsch, Peter, Kiefer, Falk, Vollstädt-Klein, Sabine

“…BackgroundCue reactivity, the enhanced sensitivity to conditioned cues, is associated with habitual and compulsive alcohol consumption. However, most previous…”
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Characterization of the Phosphoinositide 3‐Kinase‐Dependent Transcriptome in Murine Embryonic Stem Cells: Identification of Novel Regulators of Pluripotency by Storm, Michael P., Kumpfmueller, Benjamin, Thompson, Belinda, Kolde, Raivo, Vilo, Jaak, Hummel, Oliver, Schulz, Herbert, Welham, Melanie J.

“…Phosphoinositide 3‐kinase (PI3K)‐dependent signaling has been implicated in the regulation of embryonic stem (ES) cell fate. To gain further insight into the…”
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Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat by Coan, Philip M, Hummel, Oliver, Garcia Diaz, Ana, Barrier, Marjorie, Alfazema, Neza, Norsworthy, Penny J, Pravenec, Michal, Petretto, Enrico, Hübner, Norbert, Aitman, Timothy J

“…We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses…”
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Increased Proliferative Cells in the Medullary Thick Ascending Limb of the Loop of Henle in the Dahl Salt-Sensitive Rat by Yang, Chun, Stingo, Francesco C, Ahn, Kwang Woo, Liu, Pengyuan, Vannucci, Marina, Laud, Purushottam W, Skelton, Meredith, O’Connor, Paul, Kurth, Terry, Ryan, Robert P, Moreno, Carol, Tsaih, Shirng-Wern, Patone, Giannino, Hummel, Oliver, Jacob, Howard J, Liang, Mingyu, Cowley, Allen W

“…Studies of transcriptome profiles have provided new insights into mechanisms underlying the development of hypertension. Cell type heterogeneity in tissue…”
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HOXB4 Can Enhance the Differentiation of Embryonic Stem Cells by Modulating the Hematopoietic Niche by Jackson, Melany, Axton, Richard A., Taylor, A. Helen, Wilson, Julie A., Gordon-Keylock, Sabrina A.M., Kokkaliaris, Konstantinos D., Brickman, Joshua M., Schulz, Herbert, Hummel, Oliver, Hubner, Norbert, Forrester, Lesley M.

“…Hematopoietic differentiation of embryonic stem cells (ESCs) in vitro has been used as a model to study early hematopoietic development, and it is well…”
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Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives by Trouillas, Marina, Saucourt, Claire, Guillotin, Bertrand, Gauthereau, Xavier, Ding, Li, Buchholz, Frank, Doss, Michael Xavier, Sachinidis, Agapios, Hescheler, Jurgen, Hummel, Oliver, Huebner, Norbert, Kolde, Raivo, Vilo, Jaak, Schulz, Herbert, Boeuf, Hélène

“…Mouse embryonic stem (ES) cells remain pluripotent in vitro when grown in the presence of the cytokine Leukaemia Inhibitory Factor (LIF). Identification of LIF…”
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Increased Susceptibility to Complement Attack due to Down-Regulation of Decay-Accelerating Factor/CD55 in Dysferlin-Deficient Muscular Dystrophy by Wenzel, Katrin, Zabojszcza, Joanna, Carl, Miriam, Taubert, Semjon, Lass, Antje, Harris, Claire L, Ho, Mengfatt, Schulz, Herbert, Hummel, Oliver, Hubner, Norbert, Osterziel, Karl Josef, Spuler, Simone

“…Dysferlin is expressed in skeletal and cardiac muscles. However, dysferlin deficiency results in skeletal muscle weakness, but spares the heart. We compared…”
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A SNP Map of the Rat Genome Generated from cDNA Sequences by Zimdahl, Heike, Nyakatura, Gerald, Brandt, Petra, Schulz, Herbert, Hummel, Oliver, Fartmann, Berthold, Brett, David, Droege, Marcus, Monti, Jan, Lee, Young-Ae, Sun, Yinyan, Zhao, Shaying, Winter, Eitan E., Porting, Chris P., Chen, Yuan, Kasprzyk, Arek, Birney, Ewan, Ganten, Detlev, Hubner, Norbert

“…Zimdahl et al describe a map of more than 12,000 gene-based single nucleotide polymorphisms (SNPs) from transcribed regions, created by aligning cDNA sequence…”
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Adapting collections and arrays: Another step towards the automated adaptation of object ensembles by Seiffert, Dominic, Hummel, Oliver

“…•The challenge of overcoming signature mismatches for object data types is tackled.•An automated transformation mechanism is provided on well-known data…”
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Novel STAT3 Target Genes Exert Distinct Roles in the Inhibition of Mesoderm and Endoderm Differentiation in Cooperation with Nanog by Bourillot, Pierre‐Yves, Aksoy, Irène, Schreiber, Valerie, Wianny, Florence, Schulz, Herbert, Hummel, Oliver, Hubner, Norbert, Savatier, Pierre

“…Leukemia inhibitory factor (LIF) activates the transcription factor signal transducer and activator of transcription 3 (STAT3), which results in the…”
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Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats by Wenzel, Katrin, Wallukat, Gerd, Qadri, Fatimunnisa, Hubner, Norbert, Schulz, Herbert, Hummel, Oliver, Herse, Florian, Heuser, Arnd, Fischer, Robert, Heidecke, Harald, Luft, Friedrich C, Muller, Dominik N, Dietz, Rainer, Dechend, Ralf

“…Agonistic autoantibodies to the alpha(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is…”
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A Collection of Software Engineering Challenges for Big Data System Development by Hummel, Oliver, Eichelberger, Holger, Giloj, Andreas, Werle, Dominik, Schmid, Klaus

“…In recent years, the development of systems for processing and analyzing large amounts of data (so-called Big Data) has become an important sub-discipline of…”
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