Search Results - "Humm, J. L."

Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody by Schwartz, J, Jaggi, J S, O'Donoghue, J A, Ruan, S, McDevitt, M, Larson, S M, Scheinberg, D A, Humm, J L

“…Clinical therapeutic studies using (225)Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting…”
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Four-dimensional (4D) PET/CT imaging of the thorax by Nehmeh, S. A., Erdi, Y. E., Pan, T., Pevsner, A., Rosenzweig, K. E., Yorke, E., Mageras, G. S., Schoder, H., Vernon, Phil, Squire, O., Mostafavi, H., Larson, S. M., Humm, J. L.

“…We have reported in our previous studies on the methodology, and feasibility of 4D-PET (Gated PET) acquisition, to reduce respiratory motion artifact in PET…”
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Quantitation of respiratory motion during 4D-PET/CT acquisition by Nehmeh, S. A., Erdi, Y. E., Pan, T., Yorke, E., Mageras, G. S., Rosenzweig, K. E., Schoder, H., Mostafavi, H., Squire, O., Pevsner, A., Larson, S. M., Humm, J. L.

“…We report on the variability of the respiratory motion during 4D-PET/CT acquisition. The respiratory motion for five lung cancer patients was monitored by…”
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Phase and amplitude binning for 4D-CT imaging by Abdelnour, A F, Nehmeh, S A, Pan, T, Humm, J L, Vernon, P, Schöder, H, Rosenzweig, K E, Mageras, G S, Yorke, E, Larson, S M, Erdi, Y E

“…We compare the consistency and accuracy of two image binning approaches used in 4D-CT imaging. One approach, phase binning (PB), assigns each breathing cycle…”
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Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer by Nehmeh, S. A., Erdi, Y. E., Ling, C. C., Rosenzweig, K. E., Squire, O. D., Braban, L. E., Ford, E., Sidhu, K., Mageras, G. S., Larson, S. M., Humm, J. L.

“…Positron emission tomography (PET) has shown an increase in both sensitivity and specificity over computed tomography (CT) in lung cancer. However, motion…”
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Repeatability of SUV measurements in serial PET by Schwartz, J., Humm, J. L., Gonen, M., Kalaigian, H., Schoder, H., Larson, S. M., Nehmeh, S. A.

“…Purpose : The standardized uptake value (SUV) is a quantitative measure of FDG tumor uptake frequently used as a tool to monitor therapeutic response. This…”
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Evaluation of an automated deformable image matching method for quantifying lung motion in respiration-correlated CT images by Pevsner, A., Davis, B., Joshi, S., Hertanto, A., Mechalakos, J., Yorke, E., Rosenzweig, K., Nehmeh, S., Erdi, Y. E., Humm, J. L., Larson, S., Ling, C. C., Mageras, G. S.

“…We have evaluated an automated registration procedure for predicting tumor and lung deformation based on CT images of the thorax obtained at different…”
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Radioimmunotherapy with alpha-emitting nuclides by McDevitt, M R, Sgouros, G, Finn, R D, Humm, J L, Jurcic, J G, Larson, S M, Scheinberg, D A

“…This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of…”
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A stereotactic method for the three-dimensional registration of multi-modality biologic images in animals: NMR, PET, histology, and autoradiography by Humm, J. L., Ballon, D., Hu, Y. C., Ruan, S., Chui, C., Tulipano, P. K., Erdi, A., Koutcher, J., Zakian, K., Urano, M., Zanzonico, P., Mattis, C., Dyke, J., Chen, Y., Harrington, P., O’Donoghue, J. A., Ling, C. C.

“…The objective of this work was to develop and then validate a stereotactic fiduciary marker system for tumor xenografts in rodents which could be used to…”
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Hypoxia-Induced Increase in FDG Uptake in MCF7 Cells by Burgman, Paul, O'Donoghue, Joseph A, Humm, John L, Ling, C. Clifton

“…Recent clinical data indicate that tumor hypoxia negatively affects the treatment outcome of both radiotherapy and surgery in various cancers, emphasizing the…”
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Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period by Humm, J.Leigh, Kozlowski, Dorothy A, James, Debra C, Gotts, Jeffrey E, Schallert, Timothy

“…For a period of time after unilateral brain injury, surviving neural tissue surrounding the lesion may be vulnerable to extremely high behavioral demand…”
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Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres by Kurilova, I., Bendet, A., Fung, E. K., Petre, E. N., Humm, J. L., Boas, F. E., Crane, C. H., Kemeny, N., Kingham, T. P., Cercek, A., D’Angelica, M. I., Beets-Tan, R. G. H., Sofocleous, C. T.

“…Purpose To evaluate safety and efficacy of radiation segmentectomy (RS) with 90 Y glass microspheres in patients with limited metastatic liver disease not…”
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Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved? by Humm, J.Leigh, Kozlowski, Dorothy A., Bland, Sondra T., James, Debra C., Schallert, Timothy

“…Extreme overreliance on the impaired forelimb following unilateral lesions of the forelimb representation area of the rat sensorimotor cortex (FL-SMC) leads to…”
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Use of PET to monitor the response of lung cancer to radiation treatment by Erdi, Y E, Macapinlac, H, Rosenzweig, K E, Humm, J L, Larson, S M, Erdi, A K, Yorke, E D

“…Approximately 170,000 people are diagnosed with lung cancer in the United States each year. Many of these patients receive external beam radiation for…”
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A Model of Cell Inactivation by Alpha-Particle Internal Emitters by Humm, J. L., Chin, L. M.

“…Tumor-associated antibodies labeled with 131 I and ^{90}{\rm Y}$ have been used in the treatment of malignant disease with some success. The use of…”
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Nonuniformity of Tumor Dose in Radioimmunotherapy by Humm, J. L, Cobb, L. M

“…The conventional approach to calculating tumor radiation dose from internally administered radioisotopes is by the MIRD schema. The raw input data for such…”
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An iterative technique to segment PET lesions using a Monte Carlo based mathematical model by Nehmeh, S. A., El-Zeftawy, H., Greco, C., Schwartz, J., Erdi, Y. E., Kirov, A., Schmidtlein, C. R., Gyau, A. B., Larson, S. M., Humm, J. L.

“…Purpose: The need for an accurate lesion segmentation tool in F 18 DG PET is a prerequisite for the estimation of lesion response to therapy, for radionuclide…”
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KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver by Popovic, M., Talarico, O., van den Hoff, J., Kunin, H., Zhang, Z., Lafontaine, D., Dogan, S., Leung, J., Kaye, E., Czmielewski, C., Mayerhoefer, M. E., Zanzonico, P., Yaeger, R., Schöder, H., Humm, J. L., Solomon, S. B., Sofocleous, C. T., Kirov, A. S.

“…Background Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake…”
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Quantitative Bone Metastases Analysis Based on Image Segmentation by Erdi, Yusuf E, Humm, John L, Imbriaco, Massimo, Yeung, Henry, Larson, Steven M

“…Preliminary evidence indicates that the fraction of bone containing metastatic lesions is a strong prognostic indicator of survival longevity for prostate and…”
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Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding by Erdi, Yusuf E., Mawlawi, O., Larson, Steven M., Imbriaco, M., Yeung, H., Finn, R., Humm, John L.

“…BACKGROUND It is common protocol in radionuclide therapies to administer a tracer dose of a radiopharmaceutical, determine its lesion uptake and…”
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