Search Results - "Humes, H"

New opportunity for targeting systemic inflammation in patients with heart failure through leucocyte immunomodulation by Pitt, Bertram, Iyer, Sai Prasad N., Humes, H. David

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Immunomodulatory effects of a cell processing device to ameliorate dysregulated hyperinflammatory disease states by Westover, Angela J., Humes, H. David, Pino, Christopher J.

“…Cell directed therapy is an evolving therapeutic approach to treat organ dysfunction arising from hyperinflammation and cytokine storm by processing immune…”
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Translation of immunomodulatory therapy to treat chronic heart failure: Preclinical studies to first in human by Humes, H David, Aaronson, Keith D, Buffington, Deborah A, Sabbah, Hani N, Westover, Angela J, Yessayan, Lenar T, Szamosfalvi, Balazs, Pagani, Francis D

“…Inflammation has been associated with progression and complications of chronic heart failure (HF) but no effective therapy has yet been identified to treat…”
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Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes by Kim, Eun Jung, Chen, Caressa, Gologorsky, Rebecca, Santandreu, Ana, Torres, Alonso, Wright, Nathan, Goodin, Mark S., Moyer, Jarrett, Chui, Benjamin W., Blaha, Charles, Brakeman, Paul, Vartanian, Shant, Tang, Qizhi, David Humes, H., Fissell, William H., Roy, Shuvo

“…The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications…”
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A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury by Tumlin, James A, Galphin, Claude M, Tolwani, Ashita J, Chan, Micah R, Vijayan, Anitha, Finkel, Kevin, Szamosfalvi, Balazs, Dev, Devasmita, DaSilva, J Ricardo, Astor, Brad C, Yevzlin, Alexander S, Humes, H David

“…Acute kidney injury (AKI) is a highly morbid condition in critically ill patients that is associated with high mortality. Previous clinical studies have…”
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A digital protein microarray for COVID-19 cytokine storm monitoring by Song, Yujing, Ye, Yuxuan, Su, Shiuan-Haur, Stephens, Andrew, Cai, Tao, Chung, Meng-Ting, Han, Meilan K, Newstead, Michael W, Yessayan, Lenar, Frame, David, Humes, H David, Singer, Benjamin H, Kurabayashi, Katsuo

“…Despite widespread concern regarding cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring…”
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Treatment of Cytokine Storm in COVID-19 Patients With Immunomodulatory Therapy by Yessayan, Lenar, Szamosfalvi, Balazs, Napolitano, Lena, Singer, Benjamin, Kurabayashi, Katsuo, Song, Yujing, Westover, Angela, Humes, H. David

“…Observational evidence suggests that excessive inflammation with cytokine storm may play a critical role in development of acute respiratory distress syndrome…”
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Estimating Changes in Glomerular Filtration Rate With Fluorescein Isothiocyanate-Sinistrin During Renal Replacement Therapy by Chan, Goldia, Pino, Christopher J., Johnston, Kimberly A., Humes, H. David

“…Excreted exclusively by the kidneys, fluorescein isothiocyanate (FITC)-sinistrin can be used to measure glomerular filtration rate (GFR) and is detectable…”
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Rationale and Design of NEUTRALIZE-AKI: A Multicenter, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury Requiring Continuous Kidney Replacement Therapy by Yessayan, Lenar, Humes, H David, Scribe, Emily C, Iyer, Sai Prasad N, Chung, Kevin K

“…NEUTRALIZE-AKI is a pivotal study to evaluate the safety and effectiveness of the selective cytopheretic device (SCD) in adult patients with acute kidney…”
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Extracorporeal Immunomodulation Therapy in Acute Chronic Liver Failure With Multiorgan Failure: First in Human Use by Yessayan, Lenar T, Sharma, Pratima, Westover, Angela J, Szamosfalvi, Balazs, Humes, H David

“…Two patients presented with acute on chronic liver failure and multiorgan failure and, as typical for this disorder, they presented with hyperinflammation and…”
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The bioartificial kidney: current status and future promise by Humes, H. David, Buffington, Deborah, Westover, Angela J., Roy, Shuvo, Fissell, William H.

“…The rapid understanding of the cellular and molecular bases of organ function and disease processes will be translated in the next decade into new therapeutic…”
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Use of extracorporeal immunomodulation in a toddler with hemophagocytic lymphohistiocytosis and multisystem organ failure by Goldstein, Stuart L., Yessayan, Lenar T., Krallman, Kelli A., Collins, Michaela, Benoit, Stefanie, Westover, Angela, Humes, H. David

“…Introduction Hemophagocytic lymphohistiocytosis (HLH) is a dysregulated immune disorder in children, associated with Epstein–Barr virus (EBV) infection or…”
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Immunomodulatory therapy using a pediatric dialysis system ameliorates septic shock in miniature pigs by Johnston, Kimberly A., Pino, Christopher J., Chan, Goldia, Ketteler, Skylar K., Goldstein, Stuart L., Humes, H. David

“…Background Application of the immunomodulatory selective cytopheretic device (SCD) to enhance renal replacement therapy and improve outcomes of acute kidney…”
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Immunomodulatory Device Promotes a Shift of Circulating Monocytes to a Less Inflammatory Phenotype in Chronic Hemodialysis Patients by Szamosfalvi, Balazs, Westover, Angela, Buffington, Deborah, Yevzlin, Alexander, Humes, H David

“…Patients with end-stage renal disease (ESRD) on chronic hemodialysis (HD) suffer accelerated morbidity and mortality rates caused by cardiovascular disease and…”
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In vivo Assessment of a Manual Single Lumen Alternating Micro-Batch Hemodiafiltration System by Lanker, Sabrina L, Pino, Christopher J, Humes, H David, Chawla, Lakhmir, Johnston, Kimberly A

“…The manual single lumen alternating micro-batch hemodiafiltration (mSLAMB) system is a closed-loop dialysis system designed to provide kidney support in…”
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A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells by Ferrell, Nicholas, Desai, Ravi R., Fleischman, Aaron J., Roy, Shuvo, Humes, H. David, Fissell, William H.

“…We have developed a bilayer microfluidic system with integrated transepithelial electrical resistance (TEER) measurement electrodes to evaluate kidney…”
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Leukocyte filtration and leukocyte modulation therapy during extracorporeal cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest by VanZalen, Jensyn J., Nakashima, Takahiro, Phillips, Annie, Hill, Joseph E., Westover, Angela J., Lou, Liandi, Liao, Jinhui, Mergos, Joshua, Fogo, Garrett, Sanderson, Thomas H., Stacey, William C., Tiba, Mohamad Hakam, Humes, David H., Bartlett, Robert H., Rojas-Peña, Alvaro, Neumar, Robert W.

“…Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a feasible and effective rescue strategy for prolonged cardiac arrest (CA). However,…”
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The future of hemodialysis membranes by Humes, H.D., Fissell, W.H., Tiranathanagul, K.

“…Hemodialytic treatment of patients with either acute or chronic renal failure has had a dramatic impact on the mortality rates of these patients…”
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Efficacy and Safety of Renal Tubule Cell Therapy for Acute Renal Failure by TUMLIN, James, WALI, Ravinder, FINKEL, Kevin W, KRAUS, Michael A, HUMES, H. David, WILLIAMS, Winfred, MURRAY, Patrick, TOLWANI, Ashita J, VINNIKOVA, Anna K, SZERLIP, Harold M, JIUMING YE, PAGANINI, Emil P, DWORKIN, Lance

“…The mortality rate for patients with acute renal failure (ARF) remains unacceptably high. Although dialysis removes waste products and corrects fluid…”
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Novel Leukocyte Modulator Device Reduces the Inflammatory Response to Cardiopulmonary Bypass by Johnston, Kimberly A, Westover, Angela J, Rojas-Pena, Alvaro, Haft, Jonathan W, Toomasian, John M, Johnson, Thomas, Buffington, Deborah A, Humes, H David

“…Leukocyte (LE) activation during cardiopulmonary bypass (CPB) promotes a systemic inflammatory response that contributes to organ injury and postoperative…”
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