Search Results - "Humes, David H."

Immunomodulatory effects of a cell processing device to ameliorate dysregulated hyperinflammatory disease states by Westover, Angela J., Humes, H. David, Pino, Christopher J.

“…Cell directed therapy is an evolving therapeutic approach to treat organ dysfunction arising from hyperinflammation and cytokine storm by processing immune…”
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Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes by Kim, Eun Jung, Chen, Caressa, Gologorsky, Rebecca, Santandreu, Ana, Torres, Alonso, Wright, Nathan, Goodin, Mark S., Moyer, Jarrett, Chui, Benjamin W., Blaha, Charles, Brakeman, Paul, Vartanian, Shant, Tang, Qizhi, David Humes, H., Fissell, William H., Roy, Shuvo

“…The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications…”
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A digital protein microarray for COVID-19 cytokine storm monitoring by Song, Yujing, Ye, Yuxuan, Su, Shiuan-Haur, Stephens, Andrew, Cai, Tao, Chung, Meng-Ting, Han, Meilan K, Newstead, Michael W, Yessayan, Lenar, Frame, David, Humes, H David, Singer, Benjamin H, Kurabayashi, Katsuo

“…Despite widespread concern regarding cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring…”
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Translation of immunomodulatory therapy to treat chronic heart failure: Preclinical studies to first in human by Humes, H David, Aaronson, Keith D, Buffington, Deborah A, Sabbah, Hani N, Westover, Angela J, Yessayan, Lenar T, Szamosfalvi, Balazs, Pagani, Francis D

“…Inflammation has been associated with progression and complications of chronic heart failure (HF) but no effective therapy has yet been identified to treat…”
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Leukocyte filtration and leukocyte modulation therapy during extracorporeal cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest by VanZalen, Jensyn J., Nakashima, Takahiro, Phillips, Annie, Hill, Joseph E., Westover, Angela J., Lou, Liandi, Liao, Jinhui, Mergos, Joshua, Fogo, Garrett, Sanderson, Thomas H., Stacey, William C., Tiba, Mohamad Hakam, Humes, David H., Bartlett, Robert H., Rojas-Peña, Alvaro, Neumar, Robert W.

“…Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a feasible and effective rescue strategy for prolonged cardiac arrest (CA). However,…”
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Immunomodulatory Device Promotes a Shift of Circulating Monocytes to a Less Inflammatory Phenotype in Chronic Hemodialysis Patients by Szamosfalvi, Balazs, Westover, Angela, Buffington, Deborah, Yevzlin, Alexander, Humes, H David

“…Patients with end-stage renal disease (ESRD) on chronic hemodialysis (HD) suffer accelerated morbidity and mortality rates caused by cardiovascular disease and…”
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A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury by Tumlin, James A, Galphin, Claude M, Tolwani, Ashita J, Chan, Micah R, Vijayan, Anitha, Finkel, Kevin, Szamosfalvi, Balazs, Dev, Devasmita, DaSilva, J Ricardo, Astor, Brad C, Yevzlin, Alexander S, Humes, H David

“…Acute kidney injury (AKI) is a highly morbid condition in critically ill patients that is associated with high mortality. Previous clinical studies have…”
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Efficacy and Safety of Renal Tubule Cell Therapy for Acute Renal Failure by TUMLIN, James, WALI, Ravinder, FINKEL, Kevin W, KRAUS, Michael A, HUMES, H. David, WILLIAMS, Winfred, MURRAY, Patrick, TOLWANI, Ashita J, VINNIKOVA, Anna K, SZERLIP, Harold M, JIUMING YE, PAGANINI, Emil P, DWORKIN, Lance

“…The mortality rate for patients with acute renal failure (ARF) remains unacceptably high. Although dialysis removes waste products and corrects fluid…”
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Experience With Pediatric Medical Device Development by Humes, H David, Westover, Angela J

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Extracorporeal Immunomodulation Treatment and Clinical Outcomes in ICU COVID-19 Patients by Yessayan, Lenar T, Neyra, Javier A, Westover, Angela J, Szamosfalvi, Balazs, Humes, H David

“…To evaluate safety and clinical outcomes of extracorporeal immunomodulation treatment with a selective cytopheretic device (SCD) in COVID-19 ICU patients with…”
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Novel Leukocyte Modulator Device Reduces the Inflammatory Response to Cardiopulmonary Bypass by Johnston, Kimberly A, Westover, Angela J, Rojas-Pena, Alvaro, Haft, Jonathan W, Toomasian, John M, Johnson, Thomas, Buffington, Deborah A, Humes, H David

“…Leukocyte (LE) activation during cardiopulmonary bypass (CPB) promotes a systemic inflammatory response that contributes to organ injury and postoperative…”
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Current strategies and challenges in engineering a bioartificial kidney by Kim, Steven, Fissell, William H, Humes, David H, Roy, Shuvo

“…Renal replacement therapy was an early pioneer in both extra-corporeal organ replacement and whole organ transplantation. Today, the success of this pioneering…”
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Safety Summary of the Selective Cytopheretic Device: A Review of Safety Data Across Multiple Clinical Trials in ICU Patients With Acute Kidney Injury and Multiple Organ Failure by Humes, H. David, Goldstein, Stuart L., Yessayan, Lenar T., Catanzaro, David A., Scribe, Emily C., Iyer, Sai Prasad N., Chung, Kevin K.

“…OBJECTIVES: Acute kidney injury (AKI) requiring continuous kidney replacement therapy is a significant complication in ICU patients with mortality rates…”
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Increasing Eligibility to Transplant Through the Selective Cytopheretic Device: A Review of Case Reports Across Multiple Clinical Conditions by Iyer, Sai Prasad N, Pino, Christopher J, Yessayan, Lenar T, Goldstein, Stuart L, Weir, Matthew R, Westover, Angela J, Catanzaro, David A, Chung, Kevin K, Humes, H David

“…A stable, minimum physiological health status is required for patients to qualify for transplant or artificial organ support eligibility to ensure the…”
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Negating Tissue Contracture Improves Volume Maintenance and Longevity of In Vivo Engineered Tissues by Lytle, Ian F., Kozlow, Jeffrey H., Zhang, Wen X., Buffington, Deborah A., Humes, H. David, Brown, David L.

“…Engineering large, complex tissues in vivo requires robust vascularization to optimize survival, growth, and function. Previously, the authors used a "chamber"…”
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Cell-based approaches for the treatment of systemic inflammation by Pino, Christopher J, Yevzlin, Alexander S, Lee, Kyungsoo, Westover, Angela J, Smith, Peter L, Buffington, Deborah A, Humes, H David

“…Acute and chronic solid organ failures are costly disease processes with high mortality rates. Inflammation plays a central role in both acute and chronic…”
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Regenerative Medicine and Immunomodulatory Therapy: Insights From the Kidney, Heart, Brain, and Lung by Pino, Christopher J, Westover, Angela J, Johnston, Kimberly A, Buffington, Deborah A, Humes, H David

“…Regenerative medicine was initially focused on tissue engineering to replace damaged tissues and organs with constructs derived from cells and biomaterials…”
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A biomimetic membrane device that modulates the excessive inflammatory response to sepsis by Ding, Feng, Song, Joon Ho, Jung, Ju Young, Lou, Liandi, Wang, Min, Charles, Linda, Westover, Angela, Smith, Peter L, Pino, Christopher J, Buffington, Deborah A, Humes, H David

“…Septic shock has a clinical mortality rate approaching fifty percent. The major clinical manifestations of sepsis are due to the dysregulation of the host's…”
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Stem Cell Approaches for the Treatment of Renal Failure by Brodie, James C, Humes, H David

“…The inadequacy of current treatment modalities and insufficiency of donor organs for cadaveric transplantation have driven a search for improved methods of…”
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New opportunity for targeting systemic inflammation in patients with heart failure through leucocyte immunomodulation by Pitt, Bertram, Iyer, Sai Prasad N., Humes, H. David

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