Search Results - "Humerickhouse, R A"

A phase I study assessing the safety and pharmacokinetics of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 with gemcitabine and cisplatin in patients with solid tumors by Gietema, J. A., Hoekstra, R., de Vos, F. Y. F. L., Uges, D. R. A., van der Gaast, A., Groen, H. J. M., Loos, W. J., Knight, R. A., Carr, R. A., Humerickhouse, R. A., Eskens, F. A. L. M.

“…Background: The aim of the study was to determine the safety profile, pharmacokinetics and potential drug interactions of the angiogenesis inhibitor ABT-510…”
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Differential activating and deactivating effects of natural ryanodine congeners on the calcium release channel of sarcoplasmic reticulum: evidence for separation of effects at functionally distinct sites by Humerickhouse, R A, Besch, Jr, H R, Gerzon, K, Ruest, L, Sutko, J L, Emmick, J T

“…Two novel natural ryanoids from extracts of the wood of Ryania speciosa Vahl were evaluated with sarcoplasmic reticulum (SR) vesicles for their binding…”
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Phase I Study of Eniluracil, a Dihydropyrimidine Dehydrogenase Inactivator, and Oral 5-Fluorouracil with Radiation Therapy in Patients with Recurrent or Advanced Head and Neck Cancer by HUMERICKHOUSE, R. A, DOLAN, M. E, HARAF, D. J, BROCKSTEIN, B, STENSON, K, KIES, M, SULZEN, L, RATAIN, M. J, VOKES, E. E

“…5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by…”
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Investigation of the Immunogenicity of a Protein Drug Using Equilibrium Dialysis and Liquid Chromatography Tandem Mass Spectrometry Detection by Ji, Qin C, Rodila, Ramona, Morgan, Sherry J, Humerickhouse, Rod A, El-Shourbagy, Tawakol A

“…Biotherapeutics such as protein and peptide drugs have attracted significant attention in the medical community and pharmaceutical industry in recent years…”
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High affinity C10-Oeq ester derivatives of ryanodine. Activator-selective agonists of the sarcoplasmic reticulum calcium release channel by Humerickhouse, R A, Bidasee, K R, Gerzon, K, Emmick, J T, Kwon, S, Sutko, J L, Ruest, L, Besch, H R

“…The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present…”
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Structural Determinants of High-Affinity Binding of Ryanoids to the Vertebrate Skeletal Muscle Ryanodine Receptor: A Comparative Molecular Field Analysis by Welch, William, Ahmad, Syed, Airey, Judith A, Gerzon, Koert, Humerickhouse, Rod A, Besch, Henry R. Jr, Ruest, Luc, Deslongchamps, Pierre, Sutko, John L

“…Ryanodine binds to specific membrane proteins, altering the calcium permeability of intracellular membranes. In this study 19 ryanoids were isolated or…”
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Effect of Endothelin-A Receptor Blockade With Atrasentan on Tumor Progression in Men With Hormone-Refractory Prostate Cancer: A Randomized, Phase II, Placebo-Controlled Trial by CARDUCCI, Michael A, PADLEY, Robert J, SCHMITT, Jennifer L, NELSON, Joel B, BREUL, Jurgen, VOGELZANG, Nicholas J, ZONNENBERG, Bernard A, DALIANI, Danai D, SCHULMON, Claude C, NABULSI, Azmi A, HUMERICKHOUSE, Rod A, WEINBERG, Mark A

“…To evaluate the efficacy and safety of atrasentan (ABT-627), an endothelin-A receptor antagonist, in the treatment of asymptomatic, hormone-refractory…”
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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Thrombospondin-1–Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Cancer by Hoekstra, Ronald, de Vos, Filip Y F L, Eskens, Ferry A L M, Gietema, Jourik A, van der Gaast, Ate, Groen, Harry J M, Knight, Raymond A, Carr, Robert A, Humerickhouse, Rod A, Verweij, Jaap, de Vries, Elisabeth G E

“…ABT-510 is an angiogenesis inhibitor derived from thrombospondin-1, a naturally occurring inhibitor of angiogenesis. We investigated ABT-510, which was…”
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Dose-finding and pharmacokinetic study of ABT-510 with gemcitabine and cisplatin in patients with advanced cancer by De Vos, F. Y., Hoekstra, R., Eskens, F. A. L. M., De Vries, E. G., Van der Gaast, A., Groen, H. J. M., Knight, R., Humerickhouse, R. A., Gietema, J. A., Verweij, J.

“…Abstract only…”
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Dose-finding and pharmacokinetic study of ABT-510 with gemcitabine and cisplatin in patients with advanced cancer by De Vos, F. Y., Hoekstra, R., Eskens, F. A. L. M., De Vries, E. G., Van der Gaast, A., Groen, H. J. M., Knight, R., Humerickhouse, R. A., Gietema, J. A., Verweij, J.

“…Abstract only…”
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Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: An endothelin receptor antagonist for refractory prostate cancer by ZONNENBERG, Bernard A, GROENEWEGEN, Gerard, JANUS, Todd J, LEAHY, Terri W, HUMERICKHOUSE, Rod A, ISAACSON, Jeffrey D, CARR, Robert A, VOEST, Emile

“…Evidence suggests that endothelin (ET)-1 and its primary receptor, the ET(A) receptor, may contribute to the progression of prostate and other cancers…”
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Activation and deactivation of sarcoplasmic reticulum calcium release channels: molecular dissection of mechanisms via novel semi-synthetic ryanoids by Bidasee, K.R, Besch, H.R. Jr, Gerzon, K, Humerickhouse, R.A

“…The plant alkaloids ryanodine and dehydroryanodine are high affinity, biphasic modulators of the intracellularly located, calcium-regulated calcium release…”
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Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel by Gerzon, K, Humerickhouse, R A, Besch, Jr, H R, Bidasee, K R, Emmick, J T, Roeske, R W, Tian, Z, Ruest, L, Sutko, J L

“…Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic…”
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Amino- and guanidinoacylryanodines : basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca2+-release channel by GERZON, K, HUMERICKHOUSE, R. A, BESCH, H. R, BIDASEE, K. R, EMMICK, J. T, ROESKE, R. W, ZHENPING TIAN, RUEST, L, SUTKO, J. L

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Amino- and guanidinoacylryanodines: Basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca super(2+)-release channel by Gerzon, K, Humerickhouse, R A, Besch, HR Jr, Bidasee, K R, Emmick, J T, Roeske, R W, Tian, Zhenping, Ruest, L, Sutko, J L

“…Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic…”
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