Search Results - "Hume, Joseph R"

TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells by Ng, Lih Chyuan, McCormack, Mary D., Airey, Judith A., Singer, Cherie A., Keller, Phillip S., Shen, Xiao‐Ming, Hume, Joseph R.

“…Previous studies in pulmonary arterial smooth muscle cells (PASMCs) showed that the TRPC1 channel mediates capacitative Ca 2+ entry (CCE), but the molecular…”
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Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells by Ng, Lih Chyuan, Wilson, Sean M., Hume, Joseph R.

“…Capacitative Ca 2+ entry (CCE) has been speculated to contribute to Ca 2+ influx during hypoxic pulmonary vasoconstriction (HPV). The aim of the present study…”
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Differential expression and alternative splicing of TRP channel genes in smooth muscles by Walker, R L, Hume, J R, Horowitz, B

“…Nonselective cation channels (NSCC) are targets of excitatory agonists in smooth muscle, representing the nonselective cation current I(cat). Na(+) influx…”
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Anion Transport in Heart by Hume, Joseph R, Duan, Dayue, Collier, Mei Lin, Yamazaki, Jun, Horowitz, Burton

“…Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada Hume, Joseph R., Dayue Duan, Mei Lin Collier, Jun Yamazaki,…”
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ClC‐3 chloride channel is upregulated by hypertrophy and inflammation in rat and canine pulmonary artery by Dai, Yan‐Ping, Bongalon, Shaner, Hatton, William J, Hume, Joseph R, Yamboliev, Ilia A

“…1 Cl− channels have been implicated in essential cellular functions including volume regulation, progression of cell cycle, cell proliferation and contraction,…”
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Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells by Ng, Lih Chyuan, Kyle, Barry D, Lennox, Alison R, Shen, Xiao-Ming, Hatton, William J, Hume, Joseph R

“…Previous studies have shown that, in acutely dispersed canine pulmonary artery smooth muscle cells (PASMCs), depletion of both functionally independent…”
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Heterogeneity of calcium stores and elementary release events in canine pulmonary arterial smooth muscle cells by Janiak, R, Wilson, S M, Montague, S, Hume, J R

“…To examine the nature of inositol 1,4,5-trisphosphate (IP(3))-sensitive and ryanodine (Ryn)-sensitive Ca(2+) stores in isolated canine pulmonary arterial…”
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Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3-/- mice by Yamamoto‐Mizuma, Shintaro, Wang, Ge‐Xin, Liu, Luis L., Schegg, Kathleen, Hatton, William J., Duan, Dayue, Horowitz, Burton, Lamb, Fred S., Hume, Joseph R.

“…ClC-3, a member of the large superfamily of ClC voltage-dependent Cl – channels, has been proposed as a molecular candidate responsible for volume-sensitive…”
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Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells by Wang, Ge-Xin, Hatton, William J, Wang, Grace L, Zhong, Juming, Yamboliev, Ilia, Duan, Dayue, Hume, Joseph R

“…Whether ClC-3 encodes volume-sensitive organic osmolyte and anion channels (VSOACs) remains controversial. We have shown previously that native VSOACs in some…”
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A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume by Duan, D, Cowley, S, Horowitz, B, Hume, J R

“…In many mammalian cells, ClC-3 volume-regulated chloride channels maintain a variety of normal cellular functions during osmotic perturbation. The molecular…”
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Functional and molecular expression of volume-regulated chloride channels in canine vascular smooth muscle cells by Yamazaki, Jun, Duan, Dayue, Janiak, Robert, Kuenzli, Karri, Horowitz, Burton, Hume, Joseph R.

“…We examined the possibility of functional and molecular expression of volume-regulated Cl − channels in vascular smooth muscle using the whole-cell…”
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Hypotonic Activation of Short ClC3 Isoform Is Modulated by Direct Interaction between Its Cytosolic C-terminal Tail and Subcortical Actin Filaments by McCloskey, Diana T., Doherty, Lynda, Dai, Yan-Ping, Miller, Lisa, Hume, Joseph R., Yamboliev, Ilia A.

“…Short ClC3 isoform (sClC3) functions as a volume-sensitive outwardly rectifying anion channel (VSOAC) in some cell types. In previous studies, we have shown…”
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Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum by Leblanc, Normand, Hume, Joseph R.

“…The role of sodium-calcium exchange at the sarcolemma in the release of calcium from cardiac sarcoplasmic reticulum was investigated in voltage-clamped,…”
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Functional inhibition of native volume-sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti-ClC-3 antibody by Duan, Dayue, Zhong, Juming, Hermoso, Marcela, Satterwhite, Christina M., Rossow, Charles F., Hatton, William J., Ilia Yamboliev, Horowitz, Burton, Hume, Joseph R.

“…Intracellular dialysis of NIH/3T3 cells with a commercially available anti-ClC-3 polyclonal antibody (Ab) for ≈30 min completely inhibited expressed…”
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Comparative capacitative calcium entry mechanisms in canine pulmonary and renal arterial smooth muscle cells by Wilson, Sean M., Mason, Helen S., Smith, Gregory D., Nicholson, Neil, Johnston, Louise, Janiak, Robert, Hume, Joseph R.

“…Experiments were performed to determine whether capacitative Ca 2+ entry (CCE) can be activated in canine pulmonary and renal arterial smooth muscle cells…”
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CARDIAC-SPECIFIC OVEREXPRESSION OF THE HUMAN SHORT CLC-3 CHLORIDE CHANNEL ISOFORM IN MICE by Xiong, Dazhi, Wang, Ge-Xin, Burkin, Dean J, Yamboliev, Ilia A, Singer, Cherie A, Rawat, Shanti, Scowen, Paul, Evans, Rebecca, Ye, Linda, Hatton, William J, Tian, Honglin, Keller, Phillip S, McCloskey, Diana T, Duan, Dayue, Hume, Joseph R

“…SUMMARY 1 ClC‐3 has been proposed as a molecular candidate responsible for volume‐sensitive outwardly rectifying anion channels (VSOAC) in cardiac and smooth…”
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Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells by Ostrovskaya, Olga, Goyal, Ravi, Osman, Noah, McAllister, Claire E, Pessah, Isaac N, Hume, Joseph R, Wilson, Sean M

“…Ryanodine is a selective ryanodine receptor (RyR) blocker, with binding dependent on RyR opening. In whole-cell studies, ryanodine binding can lock the RyR in…”
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Molecular mechanisms of regulation of fast-inactivating voltage-dependent transient outward K+ current in mouse heart by cell volume changes by Wang, Guan‐Lei, Wang, Ge‐Xin, Yamamoto, Shintaro, Ye, Linda, Baxter, Heather, Hume, Joseph R., Duan, Dayue

“…The K v 4.2/4.3 channels are the primary subunits that contribute to the fast-inactivating, voltage-dependent transient outward K + current ( I to,fast ) in…”
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Functional Characterization of Novel Alternatively Spliced ClC-2 Chloride Channel Variants in the Heart by Britton, Fiona C, Wang, Guan-Lei, Huang, Z Maggie, Ye, Linda, Horowitz, Burton, Hume, Joseph R, Duan, Dayue

“…A novel volume-regulated hyperpolarization-activated chloride inward rectifier channel (Cl.ir) was identified in mammalian heart. To investigate whether ClC-2…”
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Prominent role of intracellular Ca2+ release in hypoxic vasoconstriction of canine pulmonary artery by Jabr, Rita I., Toland, Helen, Gelband, Craig H., Xia Wang, Xiao, Hume, Joseph R.

“…1 The possible role of sarcoplasmic reticulum (SR) Ca2+ stores in hypoxic pulmonary vasoconstriction (HPV) is not well understood. In order to assess the…”
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