Search Results - "Hume, David A"

The Many Alternative Faces of Macrophage Activation by Hume, David A

“…Monocytes and macrophages provide the first line of defense against pathogens. They also initiate acquired immunity by processing and presenting antigens and…”
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Macrophages as APC and the Dendritic Cell Myth by Hume, David A

“…Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied…”
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The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages by Hume, David A., Irvine, Katharine M., Pridans, Clare

“…The mononuclear phagocyte system (MPS) is defined as a cell lineage in which committed marrow progenitors give rise to blood monocytes and tissue macrophages…”
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Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling by Hume, David A., MacDonald, Kelli P.A.

“…Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R) promotes the differentiation of myeloid progenitors into heterogeneous…”
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Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system by Summers, Kim M, Bush, Stephen J, Hume, David A

“…The mononuclear phagocyte system (MPS) is a family of cells including progenitors, circulating blood monocytes, resident tissue macrophages, and dendritic…”
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Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity by Hume, David A.

“…Review of myeloid‐restricted transgenes used in studies of gene function in vivo, confocal and live imaging, and cell function studies. Myeloid lineage cells…”
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Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus by Rojo, Rocio, Pridans, Clare, Langlais, David, Hume, David A

“…The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF)…”
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The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche by Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A., Mabbott, Neil A.

“…Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the…”
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Graphia: A platform for the graph-based visualisation and analysis of high dimensional data by Freeman, Tom C, Horsewell, Sebastian, Patir, Anirudh, Harling-Lee, Josh, Regan, Tim, Shih, Barbara B, Prendergast, James, Hume, David A, Angus, Tim

“…Graphia is an open-source platform created for the graph-based analysis of the huge amounts of quantitative and qualitative data currently being generated from…”
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IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 by Jenkins, Stephen J, Ruckerl, Dominik, Thomas, Graham D, Hewitson, James P, Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M, Hume, David A, Allen, Judith E

“…Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells. We…”
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Phenotypic impacts of CSF1R deficiencies in humans and model organisms by Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare, Irvine, Katharine M.

“…Mϕ proliferation, differentiation, and survival are controlled by signals from the Mϕ CSF receptor (CSF1R). Mono‐allelic gain‐of‐function mutations in CSF1R in…”
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An expression atlas of human primary cells: inference of gene function from coexpression networks by Mabbott, Neil A, Baillie, J Kenneth, Brown, Helen, Freeman, Tom C, Hume, David A

“…The specialisation of mammalian cells in time and space requires genes associated with specific pathways and functions to be co-ordinately expressed. Here we…”
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The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease by Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P., Hume, David A.

“…Review summarizes the current state of knowledge of macrophage biology in the pig, and the utility of swine as models of human disease. The biology of cells of…”
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The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages by Scott, Charlotte L., T’Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W.F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan, Guilliams, Martin

“…Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages…”
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Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology by Macdonald, Sarah E, Nolan, Matthew J, Harman, Kimberley, Boulton, Kay, Hume, David A, Tomley, Fiona M, Stabler, Richard A, Blake, Damer P

“…Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is…”
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Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity by Low, Wai Yee, Tearle, Rick, Bickhart, Derek M., Rosen, Benjamin D., Kingan, Sarah B., Swale, Thomas, Thibaud-Nissen, Françoise, Murphy, Terence D., Young, Rachel, Lefevre, Lucas, Hume, David A., Collins, Andrew, Ajmone-Marsan, Paolo, Smith, Timothy P. L., Williams, John L.

“…Rapid innovation in sequencing technologies and improvement in assembly algorithms have enabled the creation of highly contiguous mammalian genomes. Here we…”
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Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors by Nirmal, Ajit J, Regan, Tim, Shih, Barbara B, Hume, David A, Sims, Andrew H, Freeman, Tom C

“…The immune composition of the tumor microenvironment regulates processes including angiogenesis, metastasis, and the response to drugs or immunotherapy. To…”
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Identification of the macrophage‐specific promoter signature in FANTOM5 mouse embryo developmental time course data by Summers, Kim M., Hume, David A.

“…A macrophage transcriptomic signature is detectable during development in total RNA of diverse tissues of the mouse. The FANTOM5 consortium used cap analysis…”
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Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice by Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek, Blurton-Jones, Mathew

“…Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear…”
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Somatic retrotransposition alters the genetic landscape of the human brain by Baillie, J. Kenneth, Barnett, Mark W., Upton, Kyle R., Gerhardt, Daniel J., Richmond, Todd A., De Sapio, Fioravante, Brennan, Paul M., Rizzu, Patrizia, Smith, Sarah, Fell, Mark, Talbot, Richard T., Gustincich, Stefano, Freeman, Thomas C., Mattick, John S., Hume, David A., Heutink, Peter, Carninci, Piero, Jeddeloh, Jeffrey A., Faulkner, Geoffrey J.

“…Reshaping the brain's genetic circuits Mobilization of retrotransposons, genetic elements able to move around in the genome where they can become incorporated…”
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