Search Results - "Hume, David"

The Many Alternative Faces of Macrophage Activation by Hume, David A

“…Monocytes and macrophages provide the first line of defense against pathogens. They also initiate acquired immunity by processing and presenting antigens and…”
Get full text

Macrophages as APC and the Dendritic Cell Myth by Hume, David A

“…Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied…”
Get full text

Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system by Summers, Kim M, Bush, Stephen J, Hume, David A

“…The mononuclear phagocyte system (MPS) is a family of cells including progenitors, circulating blood monocytes, resident tissue macrophages, and dendritic…”
Get full text

Fate‐mapping studies in inbred mice: A model for understanding macrophage development and homeostasis? by Hume, David A.

“…The mononuclear phagocyte system (MPS) was defined in the early 1970s as a family of cells including progenitors, monocytes in the circulation, and resident…”
Get full text

Letter to the Editor: Questioning the existence of Aif1+ , Csf1r+ mesenchymal stem cells by Hume, David A

Get full text

The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages by Hume, David A., Irvine, Katharine M., Pridans, Clare

“…The mononuclear phagocyte system (MPS) is defined as a cell lineage in which committed marrow progenitors give rise to blood monocytes and tissue macrophages…”
Get full text

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling by Hume, David A., MacDonald, Kelli P.A.

“…Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R) promotes the differentiation of myeloid progenitors into heterogeneous…”
Get full text

Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells by Hume, David A., Offermanns, Stefan, Bonnavion, Remy

Get full text

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity by Hume, David A.

“…Review of myeloid‐restricted transgenes used in studies of gene function in vivo, confocal and live imaging, and cell function studies. Myeloid lineage cells…”
Get full text

Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology by Macdonald, Sarah E, Nolan, Matthew J, Harman, Kimberley, Boulton, Kay, Hume, David A, Tomley, Fiona M, Stabler, Richard A, Blake, Damer P

“…Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is…”
Get full text

Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus by Rojo, Rocio, Pridans, Clare, Langlais, David, Hume, David A

“…The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF)…”
Get more information

Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair by Sehgal, Anuj, Irvine, Katharine M., Hume, David A.

“…Macrophage colony-stimulating factor (CSF1) is the primary growth factor required for the control of monocyte and macrophage differentiation, survival,…”
Get full text

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease by Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P., Hume, David A.

“…Review summarizes the current state of knowledge of macrophage biology in the pig, and the utility of swine as models of human disease. The biology of cells of…”
Get full text

Fisher information and entanglement of non-Gaussian spin states by Strobel, Helmut, Muessel, Wolfgang, Linnemann, Daniel, Zibold, Tilman, Hume, David B., Pezzè, Luca, Smerzi, Augusto, Oberthaler, Markus K.

“…Entanglement is the key quantum resource for improving measurement sensitivity beyond classical limits. However, the production of entanglement in mesoscopic…”
Get full text

Preparation and coherent manipulation of pure quantum states of a single molecular ion by Chou, Chin-wen, Kurz, Christoph, Hume, David B., Plessow, Philipp N., Leibrandt, David R., Leibfried, Dietrich

“…By exploiting a co-trapped Ca + ion, a single CaH + ion is prepared in pure quantum states, which are coherently manipulated, using a protocol that could…”
Get full text

Homeostasis in the mononuclear phagocyte system by Jenkins, Stephen J, Hume, David A

“…Highlights • CSF1R signaling controls monocyte–macrophage homeostasis. • Macrophage replenishment from monocytes versus self-renewal varies between adult…”
Get full text

The mononuclear phagocyte system by Hume, David A

“…The mononuclear phagocyte system (MPS) has been defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages…”
Get full text

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche by Sehgal, Anuj, Donaldson, David S., Pridans, Clare, Sauter, Kristin A., Hume, David A., Mabbott, Neil A.

“…Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the…”
Get full text

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 by Jenkins, Stephen J, Ruckerl, Dominik, Thomas, Graham D, Hewitson, James P, Duncan, Sheelagh, Brombacher, Frank, Maizels, Rick M, Hume, David A, Allen, Judith E

“…Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells. We…”
Get full text

A high resolution atlas of gene expression in the domestic sheep (Ovis aries) by Clark, Emily L, Bush, Stephen J, McCulloch, Mary E B, Farquhar, Iseabail L, Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu G, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C Bruce, Freeman, Tom C, Summers, Kim M, Archibald, Alan L, Hume, David A

“…Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across…”
Get full text