Search Results - "Humberstone, Andrew J."

A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs by McCarthy, James S, Sekuloski, Silvana, Griffin, Paul M, Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Möhrle, Jörg, Trenholme, Katharine R, Humberstone, Andrew J

“…Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has…”
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Lipid-based vehicles for the oral delivery of poorly water soluble drugs by Humberstone, Andrew J., Charman, William N.

“…The use of natural and synthetic lipids has generated much academic and commercial interest as a potential formulation strategy for improving the oral…”
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Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine by Khoo, Shui-Mei, Humberstone, Andrew J, Porter, Christopher J.H, Edwards, Glenn A, Charman, William N

“…The potential for lipidic self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) to improve the oral…”
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An initial pharmacokinetic study with a Metered Dose Transdermal System® for delivery of the progestogen Nestorone® as a possible future contraceptive by Fraser, Ian S, Weisberg, Edith, Kumar, Narender, Kumar, Sushma, Humberstone, Andrew J, McCrossin, Louise, Shaw, Deborah, Tsong, Y.Y, Sitruk-Ware, Regine

“…Abstract Background Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered…”
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A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine by Humberstone, A J, Porter, C J, Charman, W N

“…Halofantrine hydrochloride (Hf.HCl) is a highly lipophilic phenanthrenemethanol antimalarial. The poor and erratic absorption of Hf after oral administration…”
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Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion by Porter, C J, Charman, S A, Humberstone, A J, Charman, W N

“…The intestinal lymphatic transport of halofantrine, an important, highly lipophilic antimalarial drug, has been studied in a conscious rat model after oral…”
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An initial pharmacokinetic study with a Metered Dose Transdermal Systemfor delivery of the progestogen Nestorone as a possible future contraceptive by Fraser, Ian S, Weisberg, Edith, Kumar, Narender, Kumar, Sushma, Humberstone, Andrew J, McCrossin, Louise, Shaw, Deborah, Tsong, Y Y, Sitruk-Ware, Regine

“…Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a…”
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Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state by Humberstone, A J, Porter, C J, Edwards, G A, Charman, W N

“…The oral bioavailability of halofantrine (Hf), a highly lipophilic phenanthrenemethanol antimalarial, is significantly enhanced when ingested with food…”
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Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum by Humberstone, A J, Cowman, A F, Horton, J, Charman, W N

“…Halofantrine (Hf) is a highly lipophilic antimalarial which significantly associates with triglyceride (TG) rich plasma lipoproteins, and this is likely…”
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A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions by Humberstone, Andrew J., Currie, Graeme J., Porter, Christopher J.H., Scanlon, Martin J., Charman, William N.

“…The development of a new and simplified, validated LC assay for the quantitation of halofantrine and desbutylhalofantrine in plasma is described. The…”
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