Search Results - "Human & experimental toxicology"

Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells by Gheena, S, Ezhilarasan, D

“…Hepatocellular carcinoma is the second most common cause of cancer death in the world and its incidence has dramatically increased worldwide in the past two…”
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Decline in sperm count in European men during the past 50 years by Sengupta, P, Borges, Jr, E, Dutta, S, Krajewska-Kulak, E

“…To investigate whether the sperm concentration of European men is deteriorating over the past 50 years of time. We analysed the data published in English…”
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Simulating real-life exposures to uncover possible risks to human health: A proposed consensus for a novel methodological approach by Tsatsakis, A M, Kouretas, D, Tzatzarakis, M N, Stivaktakis, P, Tsarouhas, K, Golokhvast, K S, Rakitskii, V N, Tutelyan, V A, Hernandez, A F, Rezaee, R, Chung, G, Fenga, C, Engin, A B, Neagu, M, Arsene, A L, Docea, A O, Gofita, E, Calina, D, Taitzoglou, I, Liesivuori, J, Hayes, A W, Gutnikov, S, Tsitsimpikou, C

“…In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses…”
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Nanotechnology: History and future by Hulla, J E, Sahu, S C, Hayes, A W

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Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis by Owumi, S E, Lewu, D O, Arunsi, U O, Oyelere, A K

“…Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use. Luteolin is a polyphenolic phytochemical that exhibits…”
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Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose by Calabrese, E J, Dhawan, G, Kapoor, R, Kozumbo, W J

“…During the early part of the past century, hundreds of clinical studies involving more than 37,000 patients were conducted that showed radiotherapy (RT) to be…”
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Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment by Magalhães, N, Carvalho, F, Dinis-Oliveira, R J

“…Diquat (1,1'-ethylene-2,2'-bipyridinium ion; DQ) is a nonselective quick-acting herbicide, which is used as contact and preharvest desiccant to control…”
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Bone marrow mesenchymal stem cells-derived exosomes reduce apoptosis and inflammatory response during spinal cord injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway by Fan, Liying, Dong, Jun, He, Xijing, Zhang, Chun, Zhang, Ting

“…Spinal cord injury (SCI) is one of the most common destructive injuries, which may lead to permanent neurological dysfunction. Currently, transplantation of…”
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Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats by Khalaf, A A, Ahmed, Wms, Moselhy, W A, Abdel-Halim, B R, Ibrahim, M A

“…Bisphenol A (BPA) is a widespread compound associated with the manufacture of many consumer products. The BPA-induced reproductive toxicity was reported to be…”
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4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes by Akakpo, J Y, Ramachandran, A, Kandel, S E, Ni, H M, Kumer, S C, Rumack, B H, Jaeschke, H

“…Liver injury due to acetaminophen (APAP) overdose is the major cause of acute liver failure in the United States. While treatment with N-acetylcysteine is the…”
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Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: a systematic review by Karami-Mohajeri, Somayyeh, Abdollahi, Mohammad

“…Pesticides, including organophosphate (OP), organochlorine (OC), and carbamate (CB) compounds, are widely used in agricultural and indoor purposes. OP and CB…”
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Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IκB-α/NF-κB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice by Guo, G, Shi, F, Zhu, J, Shao, Y, Gong, W, Zhou, G, Wu, H, She, J, Shi, W

“…Inflammatory bowel disease is a chronic immunoinflammatory disease of the gastrointestinal tract. Piperine, an alkaloid, has been reported to possess…”
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Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis by Shalkami, A S, Hassan, Mia, Bakr, A G

“…Ulcerative colitis (UC) is a chronic inflammatory disease affecting colon. The primary symptoms of UC are diarrhoea with blood and mucus and sometimes…”
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Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma by Li, Xiaoming, Li, Yunhui, Lian, Peilong, lv, Qigang, Liu, Fangfeng

“…Ferroptosis is potential to relieve drug resistance in hepatocellular carcinoma (HCC). Glutathione peroxidase 4 (GPX4) is a critical modulator of ferroptosis…”
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Exosomes derived from mmu_circ_0000623-modified ADSCs prevent liver fibrosis via activating autophagy by Zhu, M, Liu, X, Li, W, Wang, L

“…Prolonged parenchymal cell death leads to activation of fibrogenic cells, extracellular matrix accumulation, and eventually liver fibrosis. Increasing evidence…”
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Exploring the role of excess fluoride in chronic kidney disease: A review by Dharmaratne, R W

“…This review covers nearly 100 years of studies on the toxicity of fluoride on human and animal kidneys. These studies reveal that there are direct adverse…”
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Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan-induced paw edema in rats by Semis, Halil Sezgin, Gur, Cihan, Ileriturk, Mustafa, Kaynar, Ozgur, Kandemir, Fatih Mehmet

“…In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at…”
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Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats by Elnfarawy, Ahmed A, Nashy, Asmaa E, Abozaid, Alaa M, Komber, Ibrahim F, Elweshahy, Rawan H, Abdelrahman, Rehab S

“…Liver fibrosis is associated with increased mortality and morbidity. However, there is not effective treatment so far. Vinpocetine (Vinpo) is a synthetic…”
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Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats by Yadav, Rajeshwar Kumar, Mehan, Sidharth, Sahu, Rakesh, Kumar, Sumit, Khan, Andleeb, Makeen, Hafiz Antar, Al Bratty, Mohammed

“…Methylmercury (MeHg) is a neurotoxin that induces neurotoxicity and cell death in neurons. MeHg increases oligodendrocyte death, glial cell activation, and…”
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Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis by Öztürk, E, Kaymak, E, Akin, A T, Karabulut, D, Ünsal, H Murat, Yakan, B

“…Doxorubicin (DOX) is used for treatment of many cancer types. Thymoquinone (THQ) is a powerful antioxidant agent used for reducing side effects of several…”
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