Search Results - "Hum, Julia M"

Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho by Hum, Julia M, O'Bryan, Linda M, Tatiparthi, Arun K, Cass, Taryn A, Clinkenbeard, Erica L, Cramer, Martin S, Bhaskaran, Manoj, Johnson, Robert L, Wilson, Jonathan M, Smith, Rosamund C, White, Kenneth E

“…Klotho ( KL) regulates mineral metabolism, and diseases associated with KL deficiency are characterized by hyperphosphatemia and vascular calcification (VC)…”
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Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia by Clinkenbeard, Erica L, Cass, Taryn A, Ni, Pu, Hum, Julia M, Bellido, Teresita, Allen, Matthew R, White, Kenneth E

“…ABSTRACT The transgenic and knockout (KO) animals involving Fgf23 have been highly informative in defining novel aspects of mineral metabolism, but are limited…”
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Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow by Clinkenbeard, Erica L, Hanudel, Mark R, Stayrook, Keith R, Appaiah, Hitesh Nidumanda, Farrow, Emily G, Cass, Taryn A, Summers, Lelia J, Ip, Colin S, Hum, Julia M, Thomas, Joseph C, Ivan, Mircea, Richine, Briana M, Chan, Rebecca J, Clemens, Thomas L, Schipani, Ernestina, Sabbagh, Yves, Xu, Linlin, Srour, Edward F, Alvarez, Marta B, Kacena, Melissa A, Salusky, Isidro B, Ganz, Tomas, Nemeth, Elizabeta, White, Kenneth E

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Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain by Marciano, Carmela L, Hiland, Taylor A, Jackson, Krista L, Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M, Loghmani, Mary Terry, Chu, Tien-Min G, Kang, Kyung S, Lowery, Jonathan W

“…Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication,…”
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Casimersen (AMONDYS 45™): An Antisense Oligonucleotide for Duchenne Muscular Dystrophy by Assefa, Milyard, Gepfert, Addison, Zaheer, Meesam, Hum, Julia M, Skinner, Brian W

“…Casimersen (AMONDYS 45 ) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass developed by Sarepta therapeutics. It was…”
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Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies by Anloague, Aric, Mahoney, Aaron, Ogunbekun, Oladipupo, Hiland, Taylor A, Thompson, William R, Larsen, Bryan, Loghmani, M Terry, Hum, Julia M, Lowery, Jonathan W

“…Soft tissue manual therapies are commonly utilized by osteopathic physicians, chiropractors, physical therapists and massage therapists. These techniques are…”
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Examining the Role of Hypothalamus-Derived Neuromedin-U (NMU) in Bone Remodeling of Rats by Born-Evers, Gabriella, Orr, Ashley L, Hulsey, Elizabeth Q, Squire, Maria E, Hum, Julia M, Plotkin, Lilian, Sampson, Catherine, Hommel, Jonathan, Lowery, Jonathan W

“…Global loss of the neuropeptide Neuromedin-U (NMU) is associated with increased bone formation and high bone mass in male and female mice by twelve weeks of…”
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Hypophosphatemic Rickets: Revealing Novel Control Points for Phosphate Homeostasis by White, Kenneth E., Hum, Julia M., Econs, Michael J.

“…Rapid and somewhat surprising advances have recently been made toward understanding the molecular mechanisms causing heritable disorders of hypophosphatemia…”
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Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression by Hum, Julia M, Day, Richard N, Bidwell, Joseph P, Wang, Yingxiao, Pavalko, Fredrick M

“…Mechanical stimulation of the skeleton promotes bone gain and suppresses bone loss, ultimately resulting in improved bone strength and fracture resistance. The…”
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The Metabolic Bone Disease X-linked Hypophosphatemia: Case Presentation, Pathophysiology and Pharmacology by Vincze, Jon, Skinner, Brian W., Tucker, Katherine A., Conaway, Kory A., Lowery, Jonathan W., Hum, Julia M.

“…The authors present a stereotypical case presentation of X-linked hypophosphatemia (XLH) and provide a review of the pathophysiology and related pharmacology…”
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Addressing Motivations and Barriers to Research Involvement during Medical School among Osteopathic Medical Students in the United States by Jackson, Krista L., Ogunbekun, Oladipupo, Nick, Benjamin, Griffin, Nicole, Hamby, Tyler, Herber, Jake, Hum, Julia M., Zahl, Sarah, Baumann, Michael, Lowery, Jonathan W.

“…Involvement in research is regarded as a high-impact educational practice, which, for medical professionals, is associated with sharpened critical thinking and…”
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Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation by Reyes Fernandez, Perla C., Wright, Christian S., Masterson, Adrianna N., Yi, Xin, Tellman, Tristen V., Bonteanu, Andrei, Rust, Katie, Noonan, Megan L., White, Kenneth E., Lewis, Karl J., Sankar, Uma, Hum, Julia M., Bix, Gregory, Wu, Danielle, Robling, Alexander G., Sardar, Rajesh, Farach-Carson, Mary C., Thompson, William R.

“…Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering…”
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Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction by Young, Suzanne R L, Hum, Julia M, Rodenberg, Eric, Turner, Charles H, Pavalko, Fredrick M

“…Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical…”
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Segregating the effects of ferric citrate‐mediated iron utilization and FGF23 in a mouse model of CKD by Liesen, Michael P., Noonan, Megan L., Ni, Pu, Agoro, Rafiou, Hum, Julia M., Clinkenbeard, Erica L., Damrath, John G., Wallace, Joseph M., Swallow, Elizabeth A., Allen, Matthew R., White, Kenneth E.

“…Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) patients as a phosphate (Pi) binder for dialysis‐dependent CKD, and for iron…”
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody by Gorrell, Ruthann E, Totten, Madeline H, Schoerning, Laura J, Newby, Jordan B, Geyman, Logan J, Lawless, Warren G, Hum, Julia M, Lowery, Jonathan W

“…The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGFβ) superfamily. BMP signaling…”
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NMUR1 in the NMU-Mediated Regulation of Bone Remodeling by Hsiao, Yu-Tin, Manikowski, Kelli J., Snyder, Samantha, Griffin, Nicole, Orr, Ashley L., Hulsey, Elizabeth Q., Born-Evers, Gabriella, Zukosky, Tara, Squire, Maria E., Hum, Julia M., Metzger, Corinne E., Allen, Matthew R., Lowery, Jonathan W.

“…Neuromedin-U (NMU) is an evolutionarily conserved peptide that regulates varying physiologic effects including blood pressure, stress and allergic responses,…”
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Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy by Hum, Julia M, Siegel, Amanda P, Pavalko, Fredrick M, Day, Richard N

“…Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure…”
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The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression by Hum, Julia M, Clinkenbeard, Erica L, Ip, Colin, Cass, Taryn A, Allen, Matt, White, Kenneth E

“…Fibroblast growth factor-23 (FGF23) controls key responses to systemic phosphate increases through its phosphaturic actions on the kidney. In addition to…”
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Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement by Goode, Roy A, Hum, Julia M, Kalwat, Michael A

“…Abstract Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-cells themselves. Restoration of regulated insulin…”
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Novel functions of circulating Klotho by Hum, Julia M, O'Bryan, Linda, Smith, Rosamund C, White, Kenneth E

“…Abstract A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed…”
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