Search Results - "Hultqvist, Malin"

A Reduction in Intracellular Reactive Oxygen Species Due to a Mutation in NCF4 Promotes Autoimmune Arthritis in Mice by Winter, Susann, Hultqvist Hopkins, Malin, Laulund, Frida, Holmdahl, Rikard

“…The mechanisms linking deficits in the phagocytic NADPH oxidase 2 (NOX2) complex to autoimmunity are so far incompletely understood. Deficiency in neutrophil…”
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T cell Surface Redox Levels Determine T Cell Reactivity and Arthritis Susceptibility by Gelderman, Kyra A., Hultqvist, Malin, Holmberg, Jens, Olofsson, Peter, Holmdahl, Rikard

“…Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil…”
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Self-reactive T cells induce and perpetuate chronic relapsing arthritis by Tuncel, Jonatan, Holmberg, Jens, Haag, Sabrina, Hopkins, Malin Hultqvist, Wester-Rosenlöf, Lena, Carlsen, Stefan, Olofsson, Peter, Holmdahl, Rikard

“…CD4 T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease…”
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Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat by Tuncel, Jonatan, Haag, Sabrina, Hoffmann, Markus H, Yau, Anthony C Y, Hultqvist, Malin, Olofsson, Peter, Bäcklund, Johan, Nandakumar, Kutty Selva, Weidner, Daniela, Fischer, Anita, Leichsenring, Anna, Lange, Franziska, Haase, Claus, Lu, Shemin, Gulko, Percio S, Steiner, Günter, Holmdahl, Rikard

“…To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several…”
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Cytokine correlation analysis based on drug perturbation by Wallner, Fredrik K., Hultqvist Hopkins, Malin, Lindvall, Therese, Olofsson, Peter, Tilevik, Andreas

“…[Display omitted] •Perturbation of cytokine production by drugs predicts how cytokines are correlated.•Correlation analysis identified 58 significant pairwise…”
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Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections by Pizzolla, Angela, Hultqvist, Malin, Nilson, Bo, Grimm, Melissa J, Eneljung, Tove, Jonsson, Ing-Marie, Verdrengh, Margareta, Kelkka, Tiina, Gjertsson, Inger, Segal, Brahm H, Holmdahl, Rikard

“…Chronic granulomatous disease (CGD) is an inherited disorder characterized by recurrent life-threatening bacterial and fungal infections. CGD results from…”
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Enhanced Autoimmunity, Arthritis, and Encephalomyelitis in Mice with a Reduced Oxidative Burst Due to a Mutation in the Ncf1 Gene by Hultqvist, Malin, Olofsson, Peter, Holmberg, Jens, Bäckström, B. Thomas, Tordsson, Jesper, Holmdahl, Rikard, Mitchison, N. Avrion

“…The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele…”
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A new arthritis therapy with oxidative burst inducers by Hultqvist, Malin, Olofsson, Peter, Gelderman, Kyra A, Holmberg, Jens, Holmdahl, Rikard

“…Despite recent successes with biological agents as therapy for autoimmune inflammatory diseases such as rheumatoid arthritis (RA), many patients fail to…”
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Enhancement of Antibody-Induced Arthritis via Toll-Like Receptor 2 Stimulation Is Regulated by Granulocyte Reactive Oxygen Species by Kelkka, Tiina, Hultqvist, Malin, Nandakumar, Kutty Selva, Holmdahl, Rikard

“…The suppressive role of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) complex–derived reactive oxygen species (ROS) in adaptive…”
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Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies by Gelderman, Kyra A, Hultqvist, Malin, Olsson, Lina M, Bauer, Kristin, Pizzolla, Angela, Olofsson, Peter, Holmdahl, Rikard

“…Autoimmune diseases such as rheumatoid arthritis (RA) are chronic diseases that cannot be prevented or cured If the pathologic basis of such disease would be…”
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NOX2 mediates quiescent handling of dead cell remnants in phagocytes by Hahn, Jonas, Euler, Maximilien, Kilgus, Emelie, Kienhöfer, Deborah, Stoof, Julia, Knopf, Jasmin, Hahn, Madelaine, Harrer, Thomas, Hultqvist, Malin, Olofsson, Peter, Mokhir, Andriy, Holmdahl, Rikard, Herrmann, Martin, Schett, Georg, Muñoz, Luis E, Hoffmann, Markus H

“…The phagocyte NADPH oxidase (the NOX2 complex) generates superoxide, the precursor to reactive oxygen species (ROS). ROS possess both antimicrobial and…”
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Arthritis suppression by NADPH activation operates through an interferon-beta pathway by Olofsson, Peter, Nerstedt, Annika, Hultqvist, Malin, Nilsson, Elisabeth C, Andersson, Sofia, Bergelin, Anna, Holmdahl, Rikard

“…A polymorphism in the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCF1),…”
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Tu1741 PRECLINICAL DEVELOPMENT OF AQ312, A POTENT AND SELECTIVE SMALL MOLECULE ARYL HYDROCARBON AGONIST, FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE by Johansson, Martin H., Russell, Wayne, Hultqvist, Malin Hopkins, Lund, Johan

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Su1280 CLINICAL DEVELOPMENT OF AQ280, A POTENT AND HIGHLY SELECTIVE JAK1 INHIBITOR, FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS by Tinnerholm, Anneli, Johansson, Martin H., Hultqvist, Malin Hopkins, Lindgren, Fredrik, Lund, Johan, Tornell, Jan

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NOX2 complex-derived ROS as immune regulators by Sareila, Outi, Kelkka, Tiina, Pizzolla, Angela, Hultqvist, Malin, Holmdahl, Rikard

“…Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules that oxidize targets in a biologic system. During steady-state conditions,…”
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Novel ROS inducing compounds influence CD4+ T cell activation by Chambers, Megan, Remtulla, Alihussein HK, Dias, Irundika K., Chick, Heather, Dunér, Pontus, Olofsson, Peter, Hoffman, Markus H., Hultqvist, Malin, Griffiths, Helen R.

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The protective role of ROS in autoimmune disease by Hultqvist, Malin, Olsson, Lina M, Gelderman, Kyra A, Holmdahl, Rikard

“…For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation…”
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Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature by Kelkka, Tiina, Kienhöfer, Deborah, Hoffmann, Markus, Linja, Marjo, Wing, Kajsa, Sareila, Outi, Hultqvist, Malin, Laajala, Essi, Chen, Zhi, Vasconcelos, Júlia, Neves, Esmeralda, Guedes, Margarida, Marques, Laura, Krönke, Gerhard, Helminen, Merja, Kainulainen, Leena, Olofsson, Peter, Jalkanen, Sirpa, Lahesmaa, Riitta, Souto-Carneiro, M Margarida, Holmdahl, Rikard

“…Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by mutations in the phagocyte reactive oxygen species (ROS)-producing NOX2 enzyme…”
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Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species by Gelderman, Kyra A, Hultqvist, Malin, Pizzolla, Angela, Zhao, Ming, Nandakumar, Kutty Selva, Mattsson, Ragnar, Holmdahl, Rikard

“…Reduced capacity to produce ROS increases the severity of T cell-dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1…”
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L-64 - Reactive oxygen species ameliorate the clinical course of murine lupus by Hahn, Jonas, Kienhöfer, Deborah, Csepregi, Janka-Zsofia, Stoof, Julia, Hultqvist, Malin, Olofsson, Peter, Mocsai, Attila, Herrmann, Martin, Schett, Georg, Holmdahl, Rikard, Hoffmann, Markus

“…Systemic lupus erythematosus (SLE) is characterized by autoimmune reactivity against components of the cell's nucleus arising after insufficient removal of…”
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