Search Results - "Hultman, Per"

Autoantibodies in outbred Swiss Webster mice following exposure to gold and mercury by Amirhosseini, Mehdi, Alkaissi, Hammoudi, Hultman, Per A., Havarinasab, Said

“…Exposure to heavy metals may have toxic effects on several human organs causing morbidity and mortality. Metals may trigger or exacerbate autoimmunity in…”
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Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development by Alkaissi, Hammoudi, Havarinasab, Said, Nielsen, Jesper Bo, Söderkvist, Peter, Hultman, Per

“…Systemic autoimmune rheumatic disorders (SARD) represent important causes of morbidity and mortality in humans. The mechanisms triggering autoimmune responses…”
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Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN by Pollard, K Michael, Escalante, Gabriela M, Huang, Hua, Haraldsson, Katarina M, Hultman, Per, Christy, Joseph M, Pawar, Rahul D, Mayeux, Jessica M, Gonzalez-Quintial, Rosana, Baccala, Roberto, Beutler, Bruce, Theofilopoulos, Argyrios N, Kono, Dwight H

“…Type I IFN and nucleic acid-sensing TLRs are both strongly implicated in the pathogenesis of lupus, with most patients expressing IFN-induced genes in…”
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HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity by Lundgren, Hanna, Martinsson, Klara, Cederbrant, Karin, Jirholt, Johan, Mucs, Daniel, Madeyski-Bengtson, Katja, Havarinasab, Said, Hultman, Per

“…The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated…”
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Determination of Methylmercury, Ethylmercury, and Inorganic Mercury in Mouse Tissues, Following Administration of Thimerosal, by Species-Specific Isotope Dilution GC−Inductively Coupled Plasma-MS by Qvarnström, Johanna, Lambertsson, Lars, Havarinasab, Said, Hultman, Per, Frech, Wolfgang

“…Isotopically enriched HgO standards were used to synthesize CH3 200Hg+ and C2H5 199Hg+ using Grignard reagents. These species were employed for isotope…”
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MDM2 SNP309 promoter polymorphism and p53 mutations in urinary bladder carcinoma stage T1 by Olsson, Hans, Hultman, Per, Rosell, Johan, Söderkvist, Peter, Jahnson, Staffan

“…Urinary bladder carcinoma stage T1 is an unpredictable disease that in some cases has a good prognosis with only local or no recurrence, but in others can…”
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Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity by Martinsson, Klara, Skogh, Thomas, Mousavi, Seyed Ali, Berg, Trond, Jönsson, Jan-Ingvar, Hultman, Per

“…Inorganic mercury (Hg) induces a T-cell dependent, systemic autoimmune condition (HgIA) where activating Fcγ-receptors (FcγRs) are important for the induction…”
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The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity by Martinsson, Klara, Carlsson, Louise, Kleinau, Sandra, Hultman, Per

“…Abstract Fc-receptors for IgG (FcγR) link cellular and humoral immune responses, controlling the balance between activating and inhibitory immune responses,…”
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A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity by Cauvi, David M., Gabriel, Rodney, Kono, Dwight H., Hultman, Per, Pollard, K. Michael

“…Decay accelerating factor (DAF), a complement-regulatory protein, protects cells from bystander complement-mediated lysis and negatively regulates T cells…”
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Acceleration of Amyloid Protein A Amyloidosis by Amyloid-Like Synthetic Fibrils by Johan, Katarzyna, Westermark, Gunilla, Engstrom, Ulla, Gustavsson, Asa, Hultman, Per, Westermark, Per

“…Amyloid protein A (AA) amyloidosis is a consequence of some long-standing inflammatory conditions, and subsequently, an N-terminal fragment of the acute phase…”
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Using Single-Gene Deletions to Identify Checkpoints in the Progression of Systemic Autoimmunity by POLLARD, K. MICHAEL, HULTMAN, PER, KONO, DWIGHT H.

“…: Systemic lupus erythematosus is a multigenic disorder of unknown etiology. To investigate the roles that specific genes play in lupus, we have examined the…”
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β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity by Pollard, Kenneth M, Hultman, Per, Toomey, Christopher B, Cauvi, David M, Kono, Dwight H, Konoc, Dwight H

“…Mercury exposure in both humans and mice is associated with features of systemic autoimmunity. Murine HgCl₂-induced autoimmunity (mHgIA) requires MHC Class II,…”
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Mercury-induced inflammation and autoimmunity by Pollard, K. Michael, Cauvi, David M., Toomey, Christopher B., Hultman, Per, Kono, Dwight H.

“…Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies…”
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Secondary exposure to heavy metal in genetically susceptible mice leads to acceleration of autoimmune response by Puente-Marin, Sara, Hultman, Per, Ekstrand, Jimmy, Nielsen, Jesper Bo, Havarinasab, Said

“…Exposure to mercury (Hg) and silver (Ag) has been shown to induce autoimmune diseases in genetically susceptible rodents. Here, A.SW mice were initially…”
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In vitro lymphocyte proliferation as compared to patch test using gold, palladium and nickel by Cederbrant, K, Hultman, P, Marcusson, J A, Tibbling, L

“…A conventional lymphocyte transformation test (LTT) was compared to the commercially available MELISA (memory lymphocyte immunostimulation assay), a…”
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Mechanisms of Environment-Induced Autoimmunity by Pollard, K. Michael, Cauvi, David M, Mayeux, Jessica M, Toomey, Christopher B, Peiss, Amy K, Hultman, Per, Kono, Dwight H

“…Although numerous environmental exposures have been suggested as triggers for preclinical autoimmunity, only a few have been confidently linked to autoimmune…”
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Mechanisms of Environmental-Induced Autoimmunity by Pollard, K. Michael, Cauvi, David M., Mayeux, Jessica M., Toomey, Christopher B., Peiss, Amy K., Hultman, Per, Kono, Dwight H.

“…Although numerous environmental exposures have been suggested as triggers for pre-clinical autoimmunity, only a few have been confidently linked to autoimmune…”
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Toxicology of Autoimmune Diseases by Pollard, K. Michael, Hultman, Per, Kono, Dwight H

“…Susceptibility to most autoimmune diseases is dependent on polygenic inheritance, environmental factors, and poorly defined stochastic events. One of the…”
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Lipid membranes accelerate amyloid formation in the mouse model of AA amyloidosis by Vahdat shariat panahi, Aida, Hultman, Per, Öllinger, Karin, Westermark, Gunilla T., Lundmark, Katarzyna

“…Introduction: AA amyloidosis develops as a result of prolonged inflammation and is characterized by deposits of N-terminal proteolytic fragments of the acute…”
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Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice by Alkaissi, Hammoudi, Ekstrand, Jimmy, Jawad, Aksa, Nielsen, Jesper Bo, Havarinasab, Said, Soderkvist, Peter, Hultman, Per

“…Following human mercury (Hg) exposure, the metal accumulates in considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg have…”
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