Search Results - "Hultgren, Scott"

Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies by Klein, Roger D., Hultgren, Scott J.

“…Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatening. The continued emergence of antibiotic resistance,…”
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Urinary tract infections: epidemiology, mechanisms of infection and treatment options by Flores-Mireles, Ana L., Walker, Jennifer N., Caparon, Michael, Hultgren, Scott J.

“…Key Points Urinary tract infections (UTIs) are some of the most common bacterial infections and are caused by both Gram-negative and Gram-positive species…”
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Bacterial Amyloid Formation: Structural Insights into Curli Biogensis by Van Gerven, Nani, Klein, Roger D, Hultgren, Scott J, Remaut, Han

“…Curli are functional amyloid fibers assembled by many Gram-negative bacteria as part of an extracellular matrix that encapsulates the bacteria within a…”
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Structural biology of the chaperone-usher pathway of pilus biogenesis by Waksman, Gabriel, Hultgren, Scott J

“…Key Points Chaperone–usher (CU) pili are assembled at the outer membrane by two proteins, a periplasmic chaperone, which provides the scaffold for the correct…”
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Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era by Kostakioti, Maria, Hadjifrangiskou, Maria, Hultgren, Scott J

“…Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a multicellular behavior that facilitates and/or prolongs survival in…”
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Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist by Spaulding, Caitlin N., Klein, Roger D., Ruer, Ségolène, Kau, Andrew L., Schreiber, Henry L., Cusumano, Zachary T., Dodson, Karen W., Pinkner, Jerome S., Fremont, Daved H., Janetka, James W., Remaut, Han, Gordon, Jeffrey I., Hultgren, Scott J.

“…Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of…”
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Detection of intracellular bacterial communities in human urinary tract infection by Rosen, David A, Hooton, Thomas M, Stamm, Walter E, Humphrey, Peter A, Hultgren, Scott J

“…Urinary tract infections (UTIs) are one of the most common bacterial infections and are predominantly caused by uropathogenic Escherichia coli (UPEC). While…”
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Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection by Hannan, Thomas J, Mysorekar, Indira U, Hung, Chia S, Isaacson-Schmid, Megan L, Hultgren, Scott J

“…Chronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the…”
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Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner by O'Brien, Valerie P, Dorsey, Denise A, Hannan, Thomas J, Hultgren, Scott J

“…Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The…”
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The biology and future prospects of antivirulence therapies by Hultgren, Scott J, Cegelski, Lynette, Marshall, Garland R, Eldridge, Gary R

“…Key Points New therapeutic strategies are urgently needed to improve our chances of success in combating infectious diseases. Bacteria, such as Staphylococcus…”
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Manganese acquisition is essential for virulence of Enterococcus faecalis by Colomer-Winter, Cristina, Flores-Mireles, Ana L, Baker, Shannon P, Frank, Kristi L, Lynch, Aaron J L, Hultgren, Scott J, Kitten, Todd, Lemos, José A

“…Manganese (Mn) is an essential micronutrient that is not readily available to pathogens during infection due to an active host defense mechanism known as…”
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Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics by Timm, Morgan R, Russell, Seongmi K, Hultgren, Scott J

“…Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys, account for an estimated 400 million infections and billions…”
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Morphological plasticity as a bacterial survival strategy by Hultgren, Scott J, Justice, Sheryl S, Hunstad, David A, Cegelski, Lynette

“…Filamentation has been implicated in bacterial survival of exposure to environmental stresses, but in this Opinion, Sheryl S. Justice and colleagues propose…”
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Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling by Hospenthal, Manuela K., Redzej, Adam, Dodson, Karen, Ukleja, Marta, Frenz, Brandon, Rodrigues, Catarina, Hultgren, Scott J., DiMaio, Frank, Egelman, Edward H., Waksman, Gabriel

“…Types 1 and P pili are prototypical bacterial cell-surface appendages playing essential roles in mediating adhesion of bacteria to the urinary tract. These…”
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Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection by Nagamatsu, Kanna, Hannan, Thomas J, Guest, Randi L, Kostakioti, Maria, Hadjifrangiskou, Maria, Binkley, Jana, Dodson, Karen, Raivio, Tracy L, Hultgren, Scott J

“…Urinary tract infections (UTIs) are among the most common bacterial infections, causing considerable morbidity in females. Infection is highly recurrent…”
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Structural and energetic basis of folded-protein transport by the FimD usher by Geibel, Sebastian, Procko, Erik, Hultgren, Scott J., Baker, David, Waksman, Gabriel

“…The crystal structure of the FimD usher traversed by the tip complex of a type 1 pilus demonstrates the mechanism by which pilus subunits are assembled and…”
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Mechanisms of Uropathogenic Escherichia coli Persistence and Eradication from the Urinary Tract by Mysorekar, Indira U., Hultgren, Scott J.

“…Recurrent urinary tract infections (rUTIs) are a source of considerable morbidity in women. The infecting bacteria in both rUTIs and a de novo acute infection…”
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Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes by Di Venanzio, Gisela, Flores-Mireles, Ana L., Calix, Juan J., Haurat, M. Florencia, Scott, Nichollas E., Palmer, Lauren D., Potter, Robert F., Hibbing, Michael E., Friedman, Laura, Wang, Bin, Dantas, Gautam, Skaar, Eric P., Hultgren, Scott J., Feldman, Mario F.

“…Multidrug resistant (MDR) Acinetobacter baumannii poses a growing threat to global health. Research on Acinetobacter pathogenesis has primarily focused on…”
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Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections by Worby, Colin J, Olson, Benjamin S, Dodson, Karen W, Earl, Ashlee M, Hultgren, Scott J

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Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG by Goyal, Parveen, Krasteva, Petya V., Van Gerven, Nani, Gubellini, Francesca, Van den Broeck, Imke, Troupiotis-Tsaïlaki, Anastassia, Jonckheere, Wim, Péhau-Arnaudet, Gérard, Pinkner, Jerome S., Chapman, Matthew R., Hultgren, Scott J., Howorka, Stefan, Fronzes, Rémi, Remaut, Han

“…CsgG and CgsE form an encaging translocon for selective, iterative diffusion of curli subunits across the non-energized bacterial outer membrane. Amyloid…”
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