Search Results - "Hulse, Raymond E"

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development by Duan, Jingjing, Li, Zongli, Li, Jian, Hulse, Raymond E., Santa-Cruz, Ana, Valinsky, William C., Abiria, Sunday A., Krapivinsky, Grigory, Zhang, Jin, Clapham, David E.

“…The transient receptor potential ion channel subfamily M, member 7 (TRPM7), is a ubiquitously expressed protein that is required for mouse embryonic…”
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Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain by Li, Qufei, Wanderling, Sherry, Paduch, Marcin, Medovoy, David, Singharoy, Abhishek, McGreevy, Ryan, Villalba-Galea, Carlos A, Hulse, Raymond E, Roux, Benoît, Schulten, Klaus, Kossiakoff, Anthony, Perozo, Eduardo

“…Voltage sensor domains (VSDs) transducer changes in the electrical field across cell membranes into conformational changes that alter the activation state of…”
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Cryo-EM structure of the polycystin 2-l1 ion channel by Hulse, Raymond E, Li, Zongli, Huang, Rick K, Zhang, Jin, Clapham, David E

“…We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1…”
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Symmetry-Constrained Analysis of Pulsed Double Electron–Electron Resonance (DEER) Spectroscopy Reveals the Dynamic Nature of the KcsA Activation Gate by Dalmas, Olivier, Hyde, H. Clark, Hulse, Raymond E, Perozo, Eduardo

“…Distance determination from an echo intensity modulation obtained by pulsed double electron–electron resonance (DEER) experiment is a mathematically ill-posed…”
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Importance of lipid–pore loop interface for potassium channel structure and function by van der Cruijsen, Elwin A. W., Nand, Deepak, Weingarth, Markus, Prokofyev, Alexander, Hornig, Sönke, Cukkemane, Abhishek Arun, Bonvin, Alexandre M. J. J., Becker, Stefan, Hulse, Raymond E., Perozo, Eduardo, Pongs, Olaf, Baldus, Marc

“…Potassium (i.e., K ⁺) channels allow for the controlled and selective passage of potassium ions across the plasma membrane via a conserved pore domain. In…”
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Sperm ion channel swims into sharper focus by Clapham, David E, Hulse, Raymond E

“…Not unlike anxious parents expecting their first child, scientists have also anticipated the arrival of structural insights into a sperm ion channel called…”
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Sperm CatSper ion channel swims into sharper focus by Clapham, David E., Hulse, Raymond E.

“…Activation of the CatSper membrane ion channel triggers enhanced sperm motility, and this protein complex is required for male fertility. Structural data now…”
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Multiplexed Cytokine Protein Expression Profiles From Spreading Depression in Hippocampal Organotypic Cultures by Kunkler, Phillip E., Hulse, Raymond E., Kraig, Richard P.

“…Cytokines are involved in ischemic tolerance, including that triggered by spreading depression (SD), yet their roles in neuroprotection remain incompletely…”
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Biomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling by van der Cruijsen, Elwin A. W., Koers, Eline J., Sauvée, Claire, Hulse, Raymond E., Weingarth, Markus, Ouari, Olivier, Perozo, Eduardo, Tordo, Paul, Baldus, Marc

“…Dynamic nuclear polarization (DNP) has been shown to greatly enhance spectroscopic sensitivity, creating novel opportunities for NMR studies on complex and…”
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Conformational Dynamics at the Inner Gate of KcsA during Activation by Hulse, Raymond E, Sachleben, Joseph R, Wen, Po-Chao, Moradi, Mahmoud, Tajkhorshid, Emad, Perozo, Eduardo

“…The potassium channel KcsA offers a unique opportunity to explicitly study the dynamics of the moving parts of ion channels, yet our understanding of the…”
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Up a Hydrophobic Creek with a Short Paddle by Hulse, Raymond E., Li, Qufei, Perozo, Eduardo

“…The mechanism by which voltage-dependent ion channels sense membrane potentials has been the most intensively studied and debated topic in modern ion channel…”
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Structure, Function, and Regulation of Insulin-Degrading Enzyme by Hulse, Raymond E, Ralat, Luis A, Wei-Jen, Tang

“…The short half-life of insulin in the human body (4-6 min) prompted the search and discovery of insulin-degrading enzyme (IDE), a 110-kDa metalloprotease that…”
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Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha by Hulse, Raymond E, Swenson, Wade G, Kunkler, Phillip E, White, David M, Kraig, Richard P

“…In brain, monomeric immunoglobin G (IgG) is regarded as quiescent and only poised to initiate potentially injurious inflammatory reactions via immune complex…”
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Optical Current Source Density Analysis in Hippocampal Organotypic Culture Shows That Spreading Depression Occurs with Uniquely Reversing Currents by Kunkler, Phillip E, Hulse, Raymond E, Schmitt, Michael W, Nicholson, Charles, Kraig, Richard P

“…Spreading depression (SD) involves current flow through principal neurons, but the pattern of current flow over the expanse of susceptible tissues or…”
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Astrocytic clasmatodendrosis in hippocampal organ culture by Hulse, Raymond E., Winterfield, J., Kunkler, Phillip E., Kraig, Richard P.

“…Mechanisms by which astrocytes are irreversibly injured from ischemic brain injury remain incompletely defined. More than 90 years ago Alzheimer showed that…”
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Ion-Selectivity Filter Interactions in KCSA from 1D 87Rb+ NMR by Hulse, Raymond E., Sachleben, Joseph R., Perozo, Eduardo

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Dynamics of Conformational Transitions during KcsA Gating from EPR and Solution NMR Experiments by Hulse, Raymond E., Henzler-Wildman, Katherine, Perozo, Eduardo

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Conformational Transition of KcsA Gating and the Mechanism of its pH-Dependence by Wen, Po-Chao, Moradi, Mahmoud, Hulse, Raymond E., Perozo, Eduardo, Tajkhorshid, Emad

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Amyloid β-degrading cryptidases: insulin degrading enzyme, neprilysin, and presequence peptidase by Malito, Enrico, Hulse, Raymond E., Tang, Wei-Jen

“…The accumulation of aggregates of amyloidogenic peptides is associated with numerous human diseases. One well studied example is the association between…”
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STRUCTURE, FUNCTION, AND REGULATION OF INSULIN-DEGRADING ENZYME: Insulin and IGFs by HULSE, Raymond E, RALAT, Luis A, TANG, Wei-Jen

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