Search Results - "Hulme, H"

PREAMBLES IN TREATY INTERPRETATION by Hulme, Max H.

“…The treaty today is one of the fundamental building blocks in the global structure of international affairs. Given the astonishing proliferation of this…”
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Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury by Bahsoun, Soukaina, Kuiper, Jan-Herman, Hulme, Charlotte H., Twigg, Angus J. Armstrong, El Masri, Wagih, Glass, Clive, Soni, Bakul, Kumar, Naveen, Chowdhury, Joy Roy, Osman, Aheed, Wright, Karina T.

“…A questionnaire was developed to evaluate patients’ perspective on research aimed at improving functions and overcoming complications associated with spinal…”
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Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles by Hulme, Charlotte H, Wilson, Emma L, Peffers, Mandy J, Roberts, Sally, Simpson, Deborah M, Richardson, James B, Gallacher, Pete, Wright, Karina T

“…Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are…”
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Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome by Hulme, C. H., Stevens, A., Dunn, W., Heazell, A. E. P., Hollywood, K., Begley, P., Westwood, M., Myers, J. E.

“…The specific consequences of hyperglycaemia on placental metabolism and function are incompletely understood but likely contribute to poor pregnancy outcomes…”
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Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction by Curtis, Sophie, Jones, Carolyn J. P., Garrod, Ainslie, Hulme, Charlotte H., Heazell, Alexander E. P.

“…Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. Although the majority of cases…”
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Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation by Hulme, Charlotte H, Wilson, Emma L, Fuller, Heidi R, Roberts, Sally, Richardson, James B, Gallacher, Pete, Peffers, Mandy J, Shirran, Sally L, Botting, Catherine H, Wright, Karina T

“…Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can…”
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A high-throughput colorimetric-assay for monitoring glucose consumption by cultured trophoblast cells and placental tissue by Hulme, C.H, Westwood, M, Myers, J.E, Heazell, A.E.P

“…Abstract Diabetes mellitus is associated with abnormalities in placental structure and function and significant pregnancy complications. In vitro studies to…”
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Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening by Hulme, Charlotte H., Peffers, Mandy J., Roberts, Sally, Gallacher, Pete, Jermin, Paul, Wright, Karina T.

“…Background: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be…”
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A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications by Hulme, Charlotte H., Mennan, Claire, McCarthy, Helen S., Davies, Rebecca, Lan, Tian, Rix, Larissa, Perry, Jade, Wright, Karina

“…The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most widely reported Good Manufacturing Practice–compliant bioreactor used for the…”
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The effect of high glucose on lipid metabolism in the human placenta by Hulme, Charlotte H., Nicolaou, Anna, Murphy, Sharon A., Heazell, Alexander E. P., Myers, Jenny E., Westwood, Melissa

“…Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here…”
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Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy by Hulme, Charlotte H., Peffers, Mandy J., Harrington, Gabriel Mateus Bernardo, Wilson, Emma, Perry, Jade, Roberts, Sally, Gallacher, Pete, Jermin, Paul, Wright, Karina T.

“…Background: Biomarkers are needed to predict clinical outcomes for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive…”
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The Upscale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies by Hulme, Charlotte H, Garcia, John K, Mennan, Claire, Perry, Jade, Roberts, Sally, Norris, Kevin, Baird, Duncan, Rix, Larissa, Banerjee, Robin, Meyer, Carl, Wright, Karina T

“…Allogeneic chondrocyte therapies need to be developed to allow more individuals to be treated with a cell therapy for cartilage repair and to reduce the burden…”
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Investigation of the blood proteome in response to spinal cord injury in rodent models by Hulme, Charlotte H., Fuller, Heidi R., Riddell, John, Shirran, Sally L., Botting, Catherine H., Osman, Aheed, Wright, Karina T.

“…Study design Explanatory and mechanistic study. Objectives A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to…”
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The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood by Hulme, C H, Brown, S J, Fuller, H R, Riddell, J, Osman, A, Chowdhury, J, Kumar, N, Johnson, W E, Wright, K T

“…Study design: Review study. Objectives: The identification of prognostic biomarkers of spinal cord injury (SCI) will help to assign SCI patients to the correct…”
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Cell therapy for cartilage repair by Hulme, Charlotte H, Perry, Jade, McCarthy, Helen S, Wright, Karina T, Snow, Martyn, Mennan, Claire, Roberts, Sally

“…Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine…”
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The management of talar osteochondral lesions - Current concepts by Lan, Tian, McCarthy, Helen S., Hulme, Charlotte H., Wright, Karina T., Makwana, Nilesh

“…Osteochondral lesions of the talus (OLTs) are a common complication following trauma, involving both the articular cartilage and the underlying subchondral…”
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A systematic, data-driven approach to the combined analysis of microarray and QTL data by Rennie, C, Hulme, H, Fisher, P, Hall, L, Agaba, M, Noyes, H A, Kemp, S J, Brass, A

“…High-throughputtechnologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods,…”
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Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons by Kemp, S J, Hanotte, O, Agaba, M, Noyes, H A, Gibson, J, Archibald, A, Rennie, C, Hulme, H, Brass, A

“…An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon…”
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Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy by Hulme, Heather, Fridjonsdottir, Elva, Gunnarsdottir, Halla, Vallianatou, Theodosia, Zhang, Xiaoqun, Wadensten, Henrik, Shariatgorji, Reza, Nilsson, Anna, Bezard, Erwan, Svenningsson, Per, Andrén, Per E.

“…Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as…”
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The measurement of stress and phase fraction distributions in pre and post-transition Zircaloy oxides using nano-beam synchrotron X-ray diffraction by Swan, H., Blackmur, M.S., Hyde, J.M., Laferrere, A., Ortner, S.R., Styman, P.D., Staines, C., Gass, M., Hulme, H., Cole-Baker, A., Frankel, P.

“…Zircaloy-4 oxide stress profiles and tetragonal:monoclinic oxide phase fraction distributions were studied using nano-beam transmission X-ray diffraction…”
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