Search Results - "Hulley, Philippa"

Inhomogeneous Response of Articular Cartilage: A Three-Dimensional Multiphasic Heterogeneous Study by Manzano, Sara, Armengol, Monica, J Price, Andrew, A Hulley, Philippa, S Gill, Harinderjit, Doblaré, Manuel, Hamdy Doweidar, Mohamed

“…Articular cartilage exhibits complex mechano-electrochemical behaviour due to its anisotropy, inhomogeneity and material non-linearity. In this work, the…”
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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence by Poulsen, Raewyn C, Watts, Anna C, Murphy, Richard J, Snelling, Sarah J, Carr, Andrew J, Hulley, Philippa A

“…Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. To determine whether pharmaceutical…”
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25-Hydroxy- and 1α,25-Dihydroxycholecalciferol Have Greater Potencies than 25-Hydroxy- and 1α,25-Dihydroxyergocalciferol in Modulating Cultured Human and Mouse Osteoblast Activities by Zarei, Allahdad, Hulley, Philippa A, Sabokbar, Afsie, Javaid, M Kassim, Morovat, Alireza

“…Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and…”
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Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2 by Hulley, Philippa A, Bishop, Tammie, Vernet, Aude, Schneider, Jurgen E, Edwards, James R, Athanasou, Nick A, Knowles, Helen J

“…Osteogenic–angiogenic coupling is promoted by the hypoxia‐inducible factor 1‐alpha (HIF‐1α) transcription factor, provoking interest in HIF activation as a…”
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Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation by Knowles, Helen J, Vasilyeva, Alexandra, Sheth, Mihir, Pattinson, Oliver, May, Jonathan, Rumney, Robin M H, Hulley, Philippa A, Richards, Duncan B, Carugo, Dario, Evans, Nicholas D, Stride, Eleanor

“…Gas-loaded nanobubbles have potential as a method of oxygen delivery to increase tumour oxygenation and therapeutically alleviate tumour hypoxia. However, the…”
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Single nucleus and spatial transcriptomic profiling of healthy human hamstring tendon by Mimpen, Jolet Y., Ramos‐Mucci, Lorenzo, Paul, Claudia, Kurjan, Alina, Hulley, Philippa A., Ikwuanusi, Chinemerem T., Cohen, Carla J., Gwilym, Stephen E., Baldwin, Mathew J., Cribbs, Adam P., Snelling, Sarah J. B.

“…The molecular and cellular basis of health in human tendons remains poorly understood. Among human tendons, hamstring tendon has markedly low pathology and can…”
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Protection against Glucocorticoid-Induced Damage in Human Tenocytes by Modulation of ERK, Akt, and Forkhead Signaling by Poulsen, Raewyn C, Carr, Andrew J, Hulley, Philippa A

“…Vitamin C and insulin modulate ERK, Akt, and forkhead activity and prevent the anti-anabolic effects of glucocorticoids on tenocytes. Antiinflammatory…”
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A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups by Hulley, Philippa A, Knowles, Helen J

“…Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the…”
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Cell proliferation is a key determinant of the outcome of FOXO3a activation by Poulsen, Raewyn C., Carr, Andrew J., Hulley, Philippa A.

“…The FOXO family of forkhead transcription factors have a pivotal role in determining cell fate in response to oxidative stress. FOXO activity can either…”
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Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin by Knowles, Helen J, Chanalaris, Anastasios, Koutsikouni, Argyro, Cribbs, Adam P, Grover, Liam M, Hulley, Philippa A

“…For decades, functional primary human osteocyte cultures have been crucially needed for understanding their role in bone anabolic processes and in endocrine…”
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Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption by Hulley, Philippa A, Papadimitriou‐Olivgeri, Ioanna, Knowles, Helen J

“…ABSTRACT The link between bone and blood vessels is regulated by hypoxia and the hypoxia‐inducible transcription factor, HIF, which drives both osteogenesis…”
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Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips by Zarei, Allahdad, Hulley, Philippa A., Sabokbar, Afsie, Javaid, M. Kassim

“…Background Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that…”
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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy by Russell, R Graham G, Xia, Zhidao, Dunford, James E, Oppermann, Udo, Kwaasi, Aaron, Hulley, Philippa A, Kavanagh, Kathryn L, Triffitt, James T, Lundy, Mark W, Phipps, Roger J, Barnett, Bobby L, Coxon, Fraser P, Rogers, Michael J, Watts, Nelson B, Ebetino, Frank H

“…The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone,…”
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Using Fluorescence Recovery After Photobleaching to Study Gap Junctional Communication In Vitro by Kuzma-Kuzniarska, Maria, Yapp, Clarence, Hulley, Philippa A

“…Fluorescence recovery after photobleaching (FRAP) is a microscopy-based technique to study the movement of fluorescent molecules inside a cell. Although…”
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Platelet-Rich Plasma Protects Tenocytes From Adverse Side Effects of Dexamethasone and Ciprofloxacin by Zargar Baboldashti, Nasim, Poulsen, Raewyn C., Franklin, Sarah L., Thompson, Mark S., Hulley, Philippa A.

“…Background: Ruptured tendons heal very slowly and complete recovery from injury is uncertain. Platelet-rich plasma (PRP), a rich source of growth factors, is…”
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Modulation of Mechanical Interactions by Local Piezoelectric Effects by Brown, Cameron P., Boyd, Jennifer L., Palmer, Antony J., Phillips, Mick, Couture, Charles-Andre, Rivard, Maxime, Hulley, Philippa A., Price, Andrew J., Ruediger, Andreas, Légaré, Francois, Carr, Andrew J.

“…Piezoelectricity is a well‐established property of biological materials, yet its functional role has remained unclear. Here, a mechanical effect of…”
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Lovastatin-Mediated Changes in Human Tendon Cells by Kuzma-Kuzniarska, Maria, Cornell, Hannah R., Moneke, Michael C., Carr, Andrew J., Hulley, Philippa A.

“…Statins are among the most widely prescribed drugs worldwide. Numerous studies have shown their beneficial effects in prevention of cardiovascular disease…”
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Organotypic Culture of Bone-Like Structures Using Composite Ceramic-Fibrin Scaffolds by Iordachescu, Alexandra, Williams, Richard L, Hulley, Philippa A, Grover, Liam M

“…We have developed an organotypic culture system that allows the production of bone tissue features on a centimeter scale. A composite, calcium…”
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Characteristics of L-PRP preparations for treating Achilles tendon rupture within the PATH-2 study by Harrison, Paul, Didembourg, Marie, Wood, Alexander, Devi, Amarpreet, Dinsdale, Robert, Hazeldine, Jon, Alsousou, Joseph, Keene, David J, Hulley, Philippa, Wagland, Susan, Parsons, Scott, Thompson, Jacqueline, Byrne, Christopher, Schlüssel, Michael Maia, O'Connor, Heather, Dutton, Susan J, Lamb, Sarah E, Willett, Keith

“…Platelet-rich plasma (PRP) is an autologous preparation that has been claimed to improve healing and mechanobiological properties of tendons both in vitro and…”
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Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching by Kuzma-Kuzniarska, Maria, Yapp, Clarence, Pearson-Jones, Thomas W, Jones, Andrew K, Hulley, Philippa A

“…Gap junction-mediated intercellular communication influences a variety of cellular activities. In tendons, gap junctions modulate collagen production, are…”
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