Search Results - "Hull, Rodney"

Artificial intelligence (AI) and big data in cancer and precision oncology by Dlamini, Zodwa, Francies, Flavia Zita, Hull, Rodney, Marima, Rahaba

“…[Display omitted] Artificial intelligence (AI) and machine learning have significantly influenced many facets of the healthcare sector. Advancement in…”
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Cervical cancer in low and middle‑income countries (Review) by Hull, Rodney, Mbele, Mzwandile, Makhafola, Tshepiso, Hicks, Chindo, Wang, Shao-Ming, Reis, Rui Manuel, Mehrotra, Ravi, Mkhize-Kwitshana, Zilungile, Kibiki, Gibson, Bates, David O, Dlamini, Zodwa

“…Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma…”
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Translocator Protein (TSPO) as a Potential Biomarker in Human Cancers by Bhoola, Nimisha H, Mbita, Zukile, Hull, Rodney, Dlamini, Zodwa

“…TSPO is a receptor involved in the regulation of cellular proliferation, apoptosis and mitochondrial functions. Previous studies showed that the expression of…”
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The dual protease inhibitor lopinavir/ritonavir (LPV/r) exerts genotoxic stress on lung cells by Marima, Rahaba, Hull, Rodney, Dlamini, Zodwa, Penny, Clement

“…LPV/r induces p53 DDR in lung cells by upregulating anti-proliferative and growth-arrest genes, while downregulating pro-survival genes. Subsequently, cell…”
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Efavirenz and Lopinavir/Ritonavir Alter Cell Cycle Regulation in Lung Cancer by Marima, Rahaba, Hull, Rodney, Dlamini, Zodwa, Penny, Clement

“…Highly active anti-retroviral treatment (HAART) is currently the most effective treatment for HIV/AIDS. Additionally, HIV positive patients receiving HAART…”
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The Catastrophic HPV/HIV Dual Viral Oncogenomics in Concert with Dysregulated Alternative Splicing in Cervical Cancer by Marima, Rahaba, Hull, Rodney, Lolas, Georgios, Syrigos, Konstantinos N., Kgoebane-Maseko, Minah, Kaufmann, Andreas Martin, Dlamini, Zodwa

“…Cervical cancer is a public health problem and has devastating effects in low-to-middle-income countries (LTMICs) such as the sub-Saharan African (SSA)…”
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HIV-Associated Cancer Biomarkers: A Requirement for Early Diagnosis by Dlamini, Zodwa, Mbele, Mzwandile, Makhafola, Tshepiso J., Hull, Rodney, Marima, Rahaba

“…Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest…”
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Role of Precision Oncology in Type II Endometrial and Prostate Cancers in the African Population: Global Cancer Genomics Disparities by Marima, Rahaba, Hull, Rodney, Mbeje, Mandisa, Molefi, Thulo, Mathabe, Kgomotso, Elbagory, Abdulrahman M, Demetriou, Demetra, Dlamini, Zodwa

“…Precision oncology can be defined as molecular profiling of tumors to identify targetable alterations. Emerging research reports the high mortality rates…”
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Exploiting the Molecular Basis of Oesophageal Cancer for Targeted Therapies and Biomarkers for Drug Response: Guiding Clinical Decision-Making by Mbatha, Sikhumbuzo, Hull, Rodney, Dlamini, Zodwa

“…Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the…”
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Abnormalities in Alternative Splicing of Apoptotic Genes and Cardiovascular Diseases by Dlamini, Zodwa, Tshidino, Shonisani C, Hull, Rodney

“…Apoptosis is required for normal heart development in the embryo, but has also been shown to be an important factor in the occurrence of heart disease…”
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Exploring Water-Soluble South African Tulbaghia violacea Harv Extract as a Therapeutic Approach for Triple-Negative Breast Cancer Metastasis by Alaouna, Mohammed, Hull, Rodney, Molefi, Thulo, Khanyile, Richard, Mbodi, Langanani, Luvhengo, Thifhelimbilu Emmanuel, Chauke-Malinga, Nkhensani, Phakathi, Boitumelo, Penny, Clement, Dlamini, Zodwa

“…Triple-negative breast cancer (TNBC) accounts for approximately 20% of all breast cancer cases and is characterized by a lack of estrogen, progesterone, and…”
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Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways by Cajee, Umar-Faruq, Hull, Rodney, Ntwasa, Monde

“…Ubiquitin-like proteins (Ubls) confer diverse functions on their target proteins. The modified proteins are involved in various biological processes, including…”
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The role played by alternative splicing in antigenic variability in human endo-parasites by Hull, Rodney, Dlamini, Zodwa

“…Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite…”
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Reports of Plant-Derived Nanoparticles for Prostate Cancer Therapy by Elbagory, Abdulrahman M, Hull, Rodney, Meyer, Mervin, Dlamini, Zodwa

“…Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However,…”
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The profiling, identification, quantification and analysis of differentially expressed genes (DEGs) in response to drug treatment in lung cancer by Marima, Rahaba, Hull, Rodney, Dlamini, Zodwa, Penny, Clement

“…The profiling and identification of genes that are differentially expressed is frequently used to underpin the underlying molecular mechanisms of biological…”
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Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets by Mbita, Zukile, Hull, Rodney, Dlamini, Zodwa

“…HIV has posed a significant challenge due to the ability of the virus to both impair and evade the host's immune system. One of the most important mechanisms…”
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Competing Endogenous RNA (ceRNA) Networks and Splicing Switches in Cervical Cancer: HPV Oncogenesis, Clinical Significance and Therapeutic Opportunities by Basera, Afra, Hull, Rodney, Demetriou, Demetra, Bates, David Owen, Kaufmann, Andreas Martin, Dlamini, Zodwa, Marima, Rahaba

“…Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human…”
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MicroRNA and Alternative mRNA Splicing Events in Cancer Drug Response/Resistance: Potent Therapeutic Targets by Marima, Rahaba, Francies, Flavia Zita, Hull, Rodney, Molefi, Thulo, Oyomno, Meryl, Khanyile, Richard, Mbatha, Sikhumbuzo, Mabongo, Mzubanzi, Owen Bates, David, Dlamini, Zodwa

“…Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer…”
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Overcoming the Challenges of Phytochemicals in Triple Negative Breast Cancer Therapy: The Path Forward by Alaouna, Mohammed, Penny, Clement, Hull, Rodney, Molefi, Thulo, Chauke-Malinga, Nkhensani, Khanyile, Richard, Makgoka, Malose, Bida, Meshack, Dlamini, Zodwa

“…Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is…”
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Immunosuppressive Signaling Pathways as Targeted Cancer Therapies by Setlai, Botle Precious, Hull, Rodney, Bida, Meshack, Durandt, Chrisna, Mulaudzi, Thanyani Victor, Chatziioannou, Aristotelis, Dlamini, Zodwa

“…Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression…”
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