Search Results - "Hull, Leland E."

Primary care and mental health providers' perceptions of implementation of pharmacogenetics testing for depression prescribing by Vest, Bonnie M, Wray, Laura O, Brady, Laura A, Thase, Michael E, Beehler, Gregory P, Chapman, Sara R, Hull, Leland E, Oslin, David W

“…Pharmacogenetic testing (PGx) has the potential to improve the quality of psychiatric prescribing by considering patients' genetic profile. However, there is…”
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Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry by Parker, Margaret M., Damrauer, Scott M., Tcheandjieu, Catherine, Erbe, David, Aldinc, Emre, Hawkins, Philip N., Gillmore, Julian D., Hull, Leland E., Lynch, Julie A., Joseph, Jacob, Ticau, Simina, Flynn-Carroll, Alexander O., Deaton, Aimee M., Ward, Lucas D., Assimes, Themistocles L., Tsao, Philip S., Chang, Kyong-Mi, Rader, Daniel J., Fitzgerald, Kevin, Vaishnaw, Akshay K., Hinkle, Gregory, Nioi, Paul

“…Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin ( TTR )…”
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Self-rated family health history knowledge among All of Us program participants by Hull, Leland E., Natarajan, Pradeep

“…Disparities in access to genetics services are well-documented. Family health history is routinely used to determine whether patients should be screened for…”
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An Environmental Scan of Consumer-Initiated Germline Genetic Testing for Health Risks by Kirby, Hannah G., Rehm, Heidi L., Hull, Leland E.

“…As patient access to laboratory testing outside the clinic grows, health care providers can expect to confront increasing questions about the utility and…”
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Revisiting the Roles of Primary Care Clinicians in Genetic Medicine by Hull, Leland E, Gold, Nina B, Armstrong, Katrina A

“…This Viewpoint describes 4 approaches for primary care clinicians to incorporate genetics care into their practices, and the systems-level interventions needed…”
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VA Primary Care and Mental Health Providers’ Comfort with Genetic Testing: Survey Results from the PRIME Care Study by Hull, Leland E., Lynch, Kevin G., Oslin, David W.

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Provider Discussions of Genetic Tests With U.S. Women at Risk for a BRCA Mutation by Hull, Leland E., Haas, Jennifer S., Simon, Steven R.

“…The U.S. Preventive Services Task Force recommends that primary care providers screen unaffected women with a family history of BRCA mutation-associated…”
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Multilevel barriers and facilitators to widespread use of preconception carrier screening in the United States by Hull, Leland E., Flannery, Kelsey, Kaimal, Anjali, Sepucha, Karen, Rehm, Heidi L., Haas, Jennifer S.

“…Although preconception reproductive genetic carrier screening (RGCS) is preferred to screening during pregnancy, population-wide preconception screening is not…”
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Gene-Based Prescribing Is Here. Are Providers Ready? by Hull, Leland E., Lehmann, Lisa Soleymani, Lynch, Julie A.

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Drug–drug–gene interaction risk among opioid users in the U.S. Department of Veterans Affairs by Chanfreau-Coffinier, Catherine, Tuteja, Sony, Hull, Leland E., MacDonald, Sally, Efimova, Olga, Bates, Jill, Voora, Deepak, Oslin, David W., DuVall, Scott L., Lynch, Julie A.

“…Response to analgesic therapy is influenced by several factors including genetics and drug-drug interactions. Pharmacogenetic (PGx) variants in the CYP2D6 gene…”
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Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users by Chanfreau-Coffinier, Catherine, Hull, Leland E, Lynch, Julie A, DuVall, Scott L, Damrauer, Scott M, Cunningham, Francesca E, Voight, Benjamin F, Matheny, Michael E, Oslin, David W, Icardi, Michael S, Tuteja, Sony

“…Implementation of pharmacogenetic testing to guide drug prescribing has potential to improve drug response and prevent adverse events. Robust data exist for…”
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Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases by Truong, Buu, Hull, Leland E., Ruan, Yunfeng, Huang, Qin Qin, Hornsby, Whitney, Martin, Hilary, van Heel, David A., Wang, Ying, Martin, Alicia R., Lee, S. Hong, Natarajan, Pradeep

“…Polygenic risk scores (PRSs) are an emerging tool to predict the clinical phenotypes and outcomes of individuals. We propose PRSmix, a framework that leverages…”
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Association of Patient and Site-of-Care Characteristics With Reproductive Carrier Screening Timing in a Large Integrated Health System by Hull, Leland E, Cheng, David, Hallman, Mie H, Rieu-Werden, M L, Haas, Jennifer S

“…Reproductive genetic carrier screening can be performed prior to or during pregnancy to assess a reproductive couple's risk of having a child with a…”
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Toward greater understanding of patient decision-making around genome sequencing by Hull, Leland E, Vassy, Jason L

“…In the era of next-generation sequencing, it is essential to collect and understand the patient outcomes that result from this new technology. One critical…”
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Identifying End Users' Preferences about Structuring Pharmacogenetic Test Orders in an Electronic Health Record System by Hull, Leland E., Vassy, Jason L., Stone, Annjanette, Chanfreau-Coffinier, Catherine C., Heise, Craig W., Pratt, Victoria M., Przygodzki, Ronald, Voils, Corrine I., Voora, Deepak, Wang-Rodriguez, Jessica, Schichman, Steven A., Scheuner, Maren T.

“…Pharmacogenetics (PGx) testing can be used for detecting genetic variations that may affect an individual's anticipated metabolism of, or response to,…”
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Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease by Maamari, Dimitri J, Brockman, Deanna G, Aragam, Krishna, Pelletier, Renée C, Folkerts, Emma, Neben, Cynthia L, Okumura, Sydney, Hull, Leland E, Philippakis, Anthony A, Natarajan, Pradeep, Ellinor, Patrick T, Ng, Kenney, Zhou, Alicia Y, Khera, Amit V, Fahed, Akl C

“…State-of-the-art genetic risk interpretation for a common complex disease such as coronary artery disease (CAD) requires assessment for both monogenic…”
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Early adoption of pharmacogenetic testing for veterans prescribed psychotropic medications by Hull, Leland E, Chanfreau-Coffinier, Catherine, Tuteja, Sony, Berlowitz, Dan, Lehmann, Lisa S, Oslin, David W, Pyne, Jeffrey M, DuVall, Scott L, Lynch, Julie A

“…Describe the characteristics of providers ordering, patients receiving, and clinical impact of a psychotropic pharmacogenetic test on veteran care…”
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A pooled electronic consultation program to improve access to genetics specialists by Folkerts, Emma K., Pelletier, Renée C., Chung, Daniel C., Goldstein, Susan A., Micalizzi, Douglas S., Shannon, Kristen M., Sweetser, David A., Wong, Eugene K., Rehm, Heidi L., Hull, Leland E.

“…Given limited ambulatory access to genetics specialists, innovative service delivery solutions are needed. Electronic consultation (e-consult) programs are…”
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Clinical Impact of 21-Gene Recurrence Score Test Within the Veterans Health Administration: Utilization and Receipt of Guideline-Concordant Care by Hull, Leland E., Lynch, Julie A., Berse, Brygida B., DuVall, Scott L., Chun, Danielle S., Venne, Vicki L., Efimova, Olga V., Icardi, Michael S., Kelley, Michael J.

“…As more veterans seek breast cancer care within the Department of Veterans Affairs, we evaluated whether node-negative, hormone receptor–positive patients…”
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Drug-drug-gene interaction risk among opioid users in the U.S. Department of Veterans Affairs by Chanfreau-Coffinier, Catherine, Tuteja, Sony, Hull, Leland E., MacDonald, Sally, Efimova, Olga, Bates, Jill, Voora, Deepak, Oslin, David W., DuVall, Scott L., Lynch, Julie A.

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