Search Results - "Hull, J Heyward"

Comparison of tenofovir plasma and tissue exposure using a population pharmacokinetic model and bootstrap: a simulation study from observed data by Collins, Jon W., Heyward Hull, J., Dumond, Julie B.

“…Sparse tissue sampling with intensive plasma sampling creates a unique data analysis problem in determining drug exposure in clinically relevant tissues…”
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The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients by Walko, Christine M., Combest, Austin J., Spasojevic, Ivan, Yu, Angela Y. C., Bhushan, Shriya, Hull, J. Heyward, Hoskins, Janelle, Armstrong, Delma, Carey, Lisa, Collicio, Frances, Dees, E. Claire

“…Purpose The prodrug cyclophosphamide is metabolized by cytochrome P450(CYP)2B6 to the active metabolite, 4-hydroxycyclophosphamide (4-OH), and by CYP3A4/5 to…”
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Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact by MCNEELY, ELIZABETH B, TALAMEH, JASMINE A, ADAMS, KIRKWOOD F, HULL, J HEYWARD, SIMMONS, BRIAN, HENRY, JILL, BROUWER, KIM L. R, PATTERSON, J HERBERT

“…PURPOSEThe bioavailability of a crushed tolvaptan tablet suspended in water and administered by nasogastric (NG) tube was compared to the bioavailability from…”
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Impact of Video Technology on Efficiency of Pharmacist-Provided Anticoagulation Counseling and Patient Comprehension by Moore, Sarah J., Blair, Elizabeth A., Steeb, David R., Reed, Brent N., Hull, J. Heyward, Rodgers, Jo Ellen

“…Background: Discharge anticoagulation counseling is important for ensuring patient comprehension and optimizing clinical outcomes. As pharmacy resources become…”
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Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates by Ainslie, Garrett R, Wolf, Kristina K, Li, Yingxin, Connolly, Elizabeth A, Scarlett, Yolanda V, Hull, J Heyward, Paine, Mary F

“…Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary…”
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The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans by Ilic, Katarina, Hawke, Roy L, Thirumaran, Ranjit K, Schuetz, Erin G, Hull, J Heyward, Kashuba, Angela D M, Stewart, Paul W, Lindley, Celeste M, Chen, Mei-Ling

“…The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro…”
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Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure by Hertz, Daniel L., Walko, Christine M., Bridges, Arlene S., Hull, J. Heyward, Herendeen, Jill, Rollins, Kristan, Watkins, Paul B., Dees, E. Claire

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Paclitaxel and rosiglitazone are primarily metabolized by CYP2C8 and their in vitro metabolism by human liver…”
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Influence of range of renal function and liver disease on predictability of creatinine clearance by Hull, J H, Hak, L J, Koch, G G, Wargin, W A, Chi, S L, Mattocks, A M

“…Several formulas for predicting creatinine clearance (Ccr) are used for adjusting drug dosages but limited data are available on their accuracy in patients…”
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Effect of metoclopramide on digoxin absorption from tablets and capsules by Johnson, B F, Bustrack, J A, Urbach, D R, Hull, J H, Marwaha, R

“…The effect of metoclopramide, a drug that increases gut motility, on the consistency of digoxin absorption was examined in 16 healthy men. Each received the…”
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A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules by Brown, D D, Schmid, J, Long, R A, Hull, J H

“…Drug interactions can profoundly alter the absorption of digoxin in tablet form. This study evaluated whether digoxin solution in capsules, a new dosage form…”
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Codeine disposition in smokers and nonsmokers by Rogers, J F, Findlay, J W, Hull, J H, Butz, R F, Jones, E C, Bustrack, J A, Welch, R M

“…The bioavailability of codeine and extent of its transformation to morphine were stated in 12 smoking and 11 nonsmoking subjects after single doses 60 mg IM…”
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Bioavailability of digoxin capsules and tablets: effect of coadministered fluid volume by Bustrack, J A, Katz, J D, Hull, J H, Foster, J R, Hammond, J E, Christenson, R H

“…The effect of different coadministered fluid (water) volumes on the consistency of digoxin absorption was studied in 16 male volunteers. Each volunteer…”
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Potential anticoagulant drug interactions in ambulatory patients by Hull, J H, Murray, W J, Brown, H S, Williams, B O, Chi, S L, Koch, G G

“…Computer-generated prescription drug purchase records for ambulatory patients receiving oral anticoagulants (OAC) were studied for concomitant use of other…”
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Digital plethysmography for assessing erythrityl tetranitrate bioavailability by Hannemann, R E, Erb, R J, Stoltman, W P, Bronson, E C, Williams, E J, Long, R A, Hull, J H, Starbuck, R R

“…The bioavailability or oral, sublingual, and chewable tablets or erythrityl tetranitrate (ETN) was evaluated in 15 normal men. In a randomized, complete…”
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Gentamicin serum concentrations: pharmacokinetic predictions by Hull, J H, Sarubbi, Jr, F A

“…Recent studies that emphasize the unpredictability of gentamicin serum concentrations have cast doubt on the accuracy of commonly used dosing nomograms. We…”
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Training the "Clinical Scientist" through a Combined Industrial/Academic Fellowship by Hull, J. Heyward

“…A 2-year fellowship program providing training in clinical drug research and drug development methodology for pharmacists with clinical experience is…”
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Mathematical considerations in the estimation of peak drug concentrations under uniform and nonuniform dosing conditions by Hull, J H

“…General one-compartment model equations for computing peak drug concentrations following uniform and nonuniform dosing are discussed. Evidence is presented to…”
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Aspirin dosage for cardiovascular effects by Wenger, T L, Hull, J H

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Factors associated with nephrotoxicity and clinical outcome in patients receiving amikacin by Williams, P J, Hull, J H, Sarubbi, F A, Rogers, J F, Wargin, W A

“…Data from 60 patients treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42 of these patients, data were examined for factors…”
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Enhancement of peritoneal dialysis clearance with docusate sodium by Dunham, Cindy B., Hak, Lawrence J., Hull, J. Heyward, Mattocks, Albert M.

“…Enhancement of peritoneal dialysis clearance with docusate sodium. A study was done in rabbits to determine the effect of docusate sodium (DSS) on the…”
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